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Chemical Compound Review

Xanthurate     8-hydroxy-4-oxo-1H-quinoline- 2-carboxylic...

Synonyms: Xanthurenate, Xanthuric acid, CHEMBL312535, SureCN379760, CCRIS 4429, ...
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Disease relevance of Xanthuric acid


Psychiatry related information on Xanthuric acid


High impact information on Xanthuric acid


Chemical compound and disease context of Xanthuric acid


Biological context of Xanthuric acid


Anatomical context of Xanthuric acid


Associations of Xanthuric acid with other chemical compounds


Gene context of Xanthuric acid


Analytical, diagnostic and therapeutic context of Xanthuric acid


  1. The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway. Matthijs, S., Baysse, C., Koedam, N., Tehrani, K.A., Verheyden, L., Budzikiewicz, H., Schäfer, M., Hoorelbeke, B., Meyer, J.M., De Greve, H., Cornelis, P. Mol. Microbiol. (2004) [Pubmed]
  2. Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations. Miller, J.W., Ribaya-Mercado, J.D., Russell, R.M., Shepard, D.C., Morrow, F.D., Cochary, E.F., Sadowski, J.A., Gershoff, S.N., Selhub, J. Am. J. Clin. Nutr. (1992) [Pubmed]
  3. Kynurenine aminotransferase and glutamine transaminase K of Escherichia coli: identity with aspartate aminotransferase. Han, Q., Fang, J., Li, J. Biochem. J. (2001) [Pubmed]
  4. Konjac mannan improves the vitamin B-6 status of rats fed a vitamin B-6-deficient diet. Hayakawa, T., Iida, Y., Tsuge, H. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1999) [Pubmed]
  5. Tryptophan metabolism in animals with dermatitis. II) In guinea pigs. Costa, C., De Antoni, A., Baccichetti, F., Vanzan, S., Allegri, G. Boll. Soc. Ital. Biol. Sper. (1979) [Pubmed]
  6. Xanthurenic acid flow in 24-hour urine following L-tryptophan loading in depressive patients. Maes, M., De Ruyter, M., Suy, E. Acta psychiatrica Belgica. (1986) [Pubmed]
  7. Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite. Billker, O., Dechamps, S., Tewari, R., Wenig, G., Franke-Fayard, B., Brinkmann, V. Cell (2004) [Pubmed]
  8. Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito. Billker, O., Lindo, V., Panico, M., Etienne, A.E., Paxton, T., Dell, A., Rogers, M., Sinden, R.E., Morris, H.R. Nature (1998) [Pubmed]
  9. The gametocyte-activating factor xanthurenic acid stimulates an increase in membrane-associated guanylyl cyclase activity in the human malaria parasite Plasmodium falciparum. Muhia, D.K., Swales, C.A., Deng, W., Kelly, J.M., Baker, D.A. Mol. Microbiol. (2001) [Pubmed]
  10. Quantitation of xanthurenic acid in rabbit serum using high performance liquid chromatography. Williams, S.A., Monti, J.A., Boots, L.R., Cornwell, P.E. Am. J. Clin. Nutr. (1984) [Pubmed]
  11. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism. Rose, D.P., Leklem, J.E., Brown, R.R., Linkswiler, H.M. Am. J. Clin. Nutr. (1975) [Pubmed]
  12. Pyridoxine treatment of chemical diabetes in pregnancy. Gillmer, M.D., Mazibuko, D. Am. J. Obstet. Gynecol. (1979) [Pubmed]
  13. Improvement of oral glucose tolerance in gestational diabetes by pyridoxine. Bennink, H.J., Schreurs, W.H. British medical journal. (1975) [Pubmed]
  14. Xanthurenic acid excretion in urine after oral intake of 5 grams L-tryptophan by healthy volunteers: standardisation of the reference values. Hoes, M.J., Kreutzer, E.K., Sijben, N. J. Clin. Chem. Clin. Biochem. (1981) [Pubmed]
  15. Xanthurenic acid provokes formation of unfolded proteins in endoplasmic reticulum of the lens epithelial cells. Malina, H.Z. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  16. Abnormal signalling of 14-3-3 proteins in cells with accumulated xanthurenic acid. Malina, H.Z., Frueh, B.E. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  17. Deamination of 3-hydroxykynurenine in bovine lenses: a possible mechanism of cataract formation in general. Malina, H.Z., Martin, X.D. Graefes Arch. Clin. Exp. Ophthalmol. (1995) [Pubmed]
  18. Prooxidant action of xanthurenic acid and quinoline compounds: role of transition metals in the generation of reactive oxygen species and enhanced formation of 8-hydroxy-2'-deoxyguanosine in DNA. Murakami, K., Haneda, M., Yoshino, M. Biometals (2006) [Pubmed]
  19. Xanthurenic acid translocates proapoptotic Bcl-2 family proteins into mitochondria and impairs mitochondrial function. Malina, H.Z., Hess, O.M. BMC Cell Biol. (2004) [Pubmed]
  20. Effect of xanthurenic acid on infectivity of Plasmodium falciparum to Anopheles stephensi. Bhattacharyya, M.K., Kumar, N. Int. J. Parasitol. (2001) [Pubmed]
  21. Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status. Chiang, E.P., Bagley, P.J., Roubenoff, R., Nadeau, M., Selhub, J. J. Nutr. (2003) [Pubmed]
  22. Excitatory amino-acid receptors contribute to carotid sinus and vagus nerve evoked excitation of neurons in the nucleus of the tractus solitarius. Zhang, W., Mifflin, S.W. J. Auton. Nerv. Syst. (1995) [Pubmed]
  23. Identification of a novel fluorophore, xanthurenic acid 8- O -beta-D-glucoside in human brunescent cataract. Shirao, E., Ando, K., Inoue, A., Shirao, Y., Balasubramanian, D. Exp. Eye Res. (2001) [Pubmed]
  24. Characterization and identification of exflagellation-inducing factor in the salivary gland of Anopheles stephensi (Diptera: Culicidae). Hirai, M., Wang, J., Yoshida, S., Ishii, A., Matsuoka, H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  25. cDNA cloning, functional expression and characterization of kynurenine 3-hydroxylase of Anopheles stephensi (Diptera: Culicidae). Hirai, M., Kiuchi, M., Wang, J., Ishii, A., Matsuoka, H. Insect Mol. Biol. (2002) [Pubmed]
  26. Investigations on the nutritional status of advanced breast cancer patients. The influence of long-term treatment with megestrol acetate or tamoxifen. Schrijver, J., Alexieva-Figusch, J., van Breederode, N., van Gilse, H.A. Nutrition and cancer. (1987) [Pubmed]
  27. Structural requirements for altering the L-tryptophan metabolism in mice by organophosphorous and methylcarbamate insecticides. Pewnim, T., Seifert, J. Eur. J. Pharmacol. (1993) [Pubmed]
  28. Vitamin metabolism and the effects of multivitamin supplementation in oral contraceptive users. Amatayakul, K., Uttaravichai, C., Singkamani, R., Ruckphaopunt, S. Contraception. (1984) [Pubmed]
  29. NMDA receptors in caudal ventrolateral medulla mediate reflex airway dilation arising from the hindlimb. Solomon, I.C., Motekaitis, A.M., Wong, M.K., Kaufman, M.P. J. Appl. Physiol. (1994) [Pubmed]
  30. The photosensitiser xanthurenic acid is not present in normal human lenses. Hains, P.G., Gao, L., Truscott, R.J. Exp. Eye Res. (2003) [Pubmed]
  31. Development of a method for the in vitro production of Plasmodium vivax ookinetes. Suwanabun, N., Sattabongkot, J., Tsuboi, T., Torii, M., Maneechai, N., Rachapaew, N., Yim-amnuaychok, N., Punkitchar, V., Coleman, R.E. J. Parasitol. (2001) [Pubmed]
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