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Gene Review

ste2  -  estrogen sulfotransferase

Rattus norvegicus

Synonyms: EST-6, Estrogen sulfotransferase Ste2, Estrogen sulfotransferase, isoform 6, Estrone sulfotransferase, Ste2, ...
 
 
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Disease relevance of ste2

  • In ANG II-clamped rats, acute hypertension also provoked disappearance of NHE3 from the apical membranes (27 +/- 2% decrease of total), but NHE3 was shifted to membranes enriched in intermicrovillar cleft and dense apical tubules (step 1) rather than endosomal/lysosomal membranes (step 2) [1].
 

High impact information on ste2

  • Reconstitution experiments showed that the soluble step 2 enzyme bound to inside-out vesicles of human erythrocytes only in the presence of diacylglycerol or phospholipase C but not phospholipase A2 or D [2].
  • This step yielded an enzyme preparation (step 2 enzyme) that was 500- to 750-fold purified (relative to the tissue homogenate) and required phosphatidylserine for stability [2].
  • Mammalian estrogen sulfotransferase (EST; EC 2.8.2.4) sulfurylates the hydroxyl group of estrogenic steroids by transferring the sulfate from a cosubstrate adenosine 3'-phosphate-5'-phosphosulfate [3].
  • In this paper, we report the molecular cloning and functional characterization of a full-length complementary DNA for estrogen sulfotransferase from mouse testis [4].
  • Thus, in situ estrogen inactivation by EST is expected to increase hepatic androgen sensitivity [5].
 

Biological context of ste2

 

Anatomical context of ste2

  • Similarly, immunoblot analysis of male and female rat liver cytosols with an antibody to rat EST yields a strong immunoreactive band in rat liver cytosol from male rats but not from females [11].
  • Furthermore, localization of EST and its corresponding mRNA within the lobular unit of the liver demonstrates that only androgen-responsive hepatocytes located around the central vein contain immunoreactive EST and its corresponding mRNA [5].
  • Immunohistochemistry with MC41 demonstrated that the antigen was first detected in approximately step-2 spermatids, and distributed over the entire cytoplasmic region of spermatids from step 2 to early step 19 [12].
  • The human prostate carcinoma LNCaP cell line variants express a subset of proliferative pathways comparable to those present in normal prostate cells (LNCaP-FGC expresses both steps, LNCaP-LNO expresses step 2, LNCaP-TAC expresses step 1, LNCaP-TJA expresses neither) [6].
  • In contrast to the slow movement of Cd from mucosa into the body (step 2 of absorption), Ni is not appreciably retained in the mucosa [10].
 

Associations of ste2 with chemical compounds

 

Other interactions of ste2

 

Analytical, diagnostic and therapeutic context of ste2

References

  1. Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension. Leong, P.K., Yang, L.E., Holstein-Rathlou, N.H., McDonough, A.A. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  2. Diacylglycerol-induced translocation of diacylglycerol kinase: use of affinity-purified enzyme in a reconstitution system. Besterman, J.M., Pollenz, R.S., Booker, E.L., Cuatrecasas, P. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. Estrogen sulfotransferase of the rat liver: complementary DNA cloning and age- and sex-specific regulation of messenger RNA. Demyan, W.F., Song, C.S., Kim, D.S., Her, S., Gallwitz, W., Rao, T.R., Slomczynska, M., Chatterjee, B., Roy, A.K. Mol. Endocrinol. (1992) [Pubmed]
  4. Molecular characterization of a testis-specific estrogen sulfotransferase and aberrant liver expression in obese and diabetogenic C57BL/KsJ-db/db mice. Song, W.C., Moore, R., McLachlan, J.A., Negishi, M. Endocrinology (1995) [Pubmed]
  5. Spatio-temporal expression of estrogen sulfotransferase within the hepatic lobule of male rats: implication of in situ estrogen inactivation in androgen action. Mancini, M.A., Song, C.S., Rao, T.R., Chatterjee, B., Roy, A.K. Endocrinology (1992) [Pubmed]
  6. Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus. Geck, P., Szelei, J., Jimenez, J., Sonnenschein, C., Soto, A.M. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  7. Selenium regulates gene expression for estrogen sulfotransferase and alpha 2U-globulin in rat liver. Yang, Q., Christensen, M.J. J. Steroid Biochem. Mol. Biol. (1998) [Pubmed]
  8. Assignment of rat estrogen sulfotransferase gene (Ste) to rat chromosome band 14p21.3-->p21.2. Nagai, F., Satoh, H., Matsui, M., Tamura, H. Cytogenet. Cell Genet. (2000) [Pubmed]
  9. Regulation of sulfotransferase mRNA expression in male and female rats of various ages. Klaassen, C.D., Liu, L., Dunn, R.T. Chem. Biol. Interact. (1998) [Pubmed]
  10. On the mechanism of nickel absorption in the rat jejunum. Foulkes, E.C., McMullen, D.M. Toxicology (1986) [Pubmed]
  11. Isolation and expression of an isoform of rat estrogen sulfotransferase. Falany, J.L., Krasnykh, V., Mikheeva, G., Falany, C.N. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  12. Appearance of an intra-acrosomal antigen during the terminal step of spermiogenesis in the rat. Tanii, I., Toshimori, K., Araki, S., Oura, C. Cell Tissue Res. (1992) [Pubmed]
  13. Sulfation is rate limiting in the futile cycling between estrone and estrone sulfate in enriched periportal and perivenous rat hepatocytes. Tan, E., Pang, K.S. Drug Metab. Dispos. (2001) [Pubmed]
  14. Induction of hepatic estrogen sulfotransferase expression by hypophysectomy in female rats. Borthwick, E.B., Coughtrie, M.W., Burchell, A. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  15. Estrogen-binding properties of rat serum alpha 1-fetoprotein and its isoforms. Investigation of the apparent non-integrality of sites on the unfractionated protein. Hérve, F., Gentin, M., Rajkowski, K.M., Wong, L.T., Hsia, C.J., Cittanova, N. J. Steroid Biochem. (1990) [Pubmed]
 
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