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Gene Review

SULT1E1  -  sulfotransferase family 1E, estrogen...

Sus scrofa

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High impact information on STE


Biological context of STE

  • The EST expressed by the stably transfected CHO-K1 cells was found to manifest Michaelis-Menten kinetics and would use only estrogenic steroids as substrates, whereas other forms of steroids, such as pregnenolone, dehydroepiandrosterone, cortisol, and testosterone, were not acted on [4].
  • A 34-kilodalton EST and two HSTs with 3 alpha- and 3 beta-hydroxysteroid substrate specificities (32 and 33 kilodaltons, respectively) were previously purified from guinea pig adrenal cortex and characterized [5].
  • CHO-K1 cells transfected with the same plasmid without the EST complementary DNA insert as well as untransfected CHO-K1 cells did not demonstrate either EST activity or the presence of an immunologically related protein [4].
  • The high concentration of EST immunoreactivity in nuclei suggests that EST may play a role in modulating the ability of active estrogens to regulate gene expression in ACTH-responsive cells [5].
  • The activities of estrogen sulfotransferase, estrogen sulfatase and estradiol 17beta-dehydrogenase change considerably in the guinea pig uterine compartment during gestation [6].

Anatomical context of STE

  • In the European Reference Laboratory (EURL) a clone of this cell line, PK(15)A, and the STE (swine testicular epitheloid) cell line are in use for propagation of CSFV [7].
  • Ovoid inclusions about 1-4 microns in diameter, with no limiting membrane, were observed in zona reticularis cells; these inclusions were strongly labeled for both EST and HSTs [5].
  • EST was concentrated in cell nuclei; sparse labeling was distributed throughout the cytoplasm [5].
  • Studies have been carried out which were designed to examine the hormonal requirement for the appearance of estrogen sulfotransferase activity in porcine uteri [8].
  • Cytosolic estrogen sulfotransferase activity of chorion decreased 7-fold between stages 50 and -1 [9].

Associations of STE with chemical compounds


Other interactions of STE

  • Compared with the control, PUFA were only slightly increased in backfat of pigs fed PF, OLE, STE or OO, although dietary PUFA intake was up to 70% higher [12].

Analytical, diagnostic and therapeutic context of STE


  1. Proposed active site domain in estrogen sulfotransferase as determined by mutational analysis. Driscoll, W.J., Komatsu, K., Strott, C.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Structural and functional characterization of estrogen sulfotransferase isoforms: distinct catalytic and high affinity binding activities. Lee, Y.C., Komatsu, K., Driscoll, W.J., Strott, C.A. Mol. Endocrinol. (1994) [Pubmed]
  3. Molecular cloning and expression of a full-length complementary DNA encoding the guinea pig adrenocortical estrogen sulfotransferase. Oeda, T., Lee, Y.C., Driscoll, W.J., Chen, H.C., Strott, C.A. Mol. Endocrinol. (1992) [Pubmed]
  4. Characterization of guinea pig estrogen sulfotransferase expressed by Chinese hamster ovary cell-K1 stable transfectants. Tomizuka, T., Oeda, T., Tamura, Y., Yoshida, S., Strott, C.A. Endocrinology (1994) [Pubmed]
  5. Estrogen and hydroxysteroid sulfotransferases in guinea pig adrenal cortex: cellular and subcellular distributions. Whitnall, M.H., Driscoll, W.J., Lee, Y.C., Strott, C.A. Endocrinology (1993) [Pubmed]
  6. Sulfation by guinea pig chorion and uterus: differential action towards estrone and estradiol. Hobkirk, R. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  7. Replication of classical swine fever virus strains and isolates in different porcine cell lines. Grummer, B., Fischer, S., Depner, K., Riebe, R., Blome, S., Greiser-Wilke, I. DTW. Dtsch. Tierarztl. Wochenschr. (2006) [Pubmed]
  8. Induction of porcine uterine estrogen sulfotransferase activity by progesterone. Meyers, S.A., Lozon, M.M., Corombos, J.D., Saunders, D.E., Hunter, K., Christensen, C., Brooks, S.C. Biol. Reprod. (1983) [Pubmed]
  9. Generation of estradiol within the pregnant guinea pig uterine compartment with special reference to the myometrium. Hobkirk, R., Glasier, M.A. J. Steroid Biochem. Mol. Biol. (1993) [Pubmed]
  10. Adrenocortical pregnenolone binding activity resides with estrogen sulfotransferase. Lee, Y.C., Park, C.S., Komatsu, K., Kwack, J., Strott, C.A. Endocrinology (1995) [Pubmed]
  11. Cloning and sequence analysis of the 5'-flanking region of the estrogen sulfotransferase gene: steroid response elements and cell-specific nuclear DNA-binding proteins. Komatsu, K., Oeda, T., Strott, C.A. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  12. Effect of dietary mono- and polyunsaturated fatty acids on the fatty acid composition of pigs' adipose tissues. Gläser, K.R., Wenk, C., Scheeder, M.R. Archiv für Tierernährung. (2002) [Pubmed]
  13. Comparison of estrogen sulfotransferase and pregnenolone sulfotransferase of guinea pig. Glasier, M.A., Glutek, S.M., Hobkirk, R. Steroids (1992) [Pubmed]
  14. Heterogeneity of guinea pig chorion and liver estrogen sulfotransferases. Hobkirk, R. J. Steroid Biochem. (1988) [Pubmed]
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