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Gene Review

IL18  -  interleukin 18 (interferon-gamma-inducing...

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Disease relevance of IL18


High impact information on IL18


Biological context of IL18


Anatomical context of IL18


Associations of IL18 with chemical compounds

  • Only CVL fluid from pigs exposed to BZK showed a significant increase of IL-1beta, IL-8, and also IL-18 production when compared to the controls, PHI-443 or VDDTC-treated groups [10].
  • IL-18 and TNF-alpha mRNA expression was constant in all the samples examined [9].

Other interactions of IL18

  • As insect cells do not normally have the IL-1beta converting enzyme (caspase-1), which is required for processing of the precursor IL-18 into the mature IL-18, we recently cloned porcine caspase-1 cDNA [2].
  • TNF-alpha and IL-18 were mostly missing in plasma 24 h after infection [11].
  • The porcine mature IL-18 produced by the silkworms strongly induced interferon-gamma (IFN-gamma) production from porcine PBMC [12].

Analytical, diagnostic and therapeutic context of IL18


  1. Cloning, sequencing, and expression of porcine interleukin-18 in Escherichia coli. Oem, J.K., Song, H.J., Kang, S.W., Jeong, W.S. Mol. Cells (2000) [Pubmed]
  2. Efficient production of biologically active porcine interleukin-18 by coexpression with porcine caspase-1 using a baculovirus expression system. Muneta, Y., Inumaru, S., Shimoji, Y., Mori, Y. J. Interferon Cytokine Res. (2001) [Pubmed]
  3. IL-18 Expression in Pigs Following Infection with Mycoplasma hyopneumoniae. Muneta, Y., Minagawa, Y., Shimoji, Y., Nagata, R., Markham, P.F., Browning, G.F., Mori, Y. J. Interferon Cytokine Res. (2006) [Pubmed]
  4. Expression of interleukin-18 by porcine airway and intestinal epithelium. Muneta, Y., Goji, N., Tsuji, N.M., Mikami, O., Shimoji, Y., Nakajima, Y., Yokomizo, Y., Mori, Y. J. Interferon Cytokine Res. (2002) [Pubmed]
  5. Immunomodulatory effect of plasmids co-expressing cytokines in classical swine fever virus subunit gp55/E2-DNA vaccination. Wienhold, D., Armengol, E., Marquardt, A., Marquardt, C., Voigt, H., Büttner, M., Saalmüller, A., Pfaff, E. Vet. Res. (2005) [Pubmed]
  6. Effect of bacterial virulence on IL-18 expression in the amnion infected with Escherichia coli. Splíchalová, A., Trebichavský, I., Muneta, Y., Mori, Y., Splíchal, I. Am. J. Reprod. Immunol. (2005) [Pubmed]
  7. Bacterially induced activation of interleukin-18 in porcine intestinal mucosa. Foss, D.L., Zilliox, M.J., Murtaugh, M.P. Vet. Immunol. Immunopathol. (2001) [Pubmed]
  8. Porcine interleukin-12 fusion protein and interleukin-18 in combination induce interferon-gamma production in porcine natural killer and T cells. Domeika, K., Berg, M., Eloranta, M.L., Alm, G.V. Vet. Immunol. Immunopathol. (2002) [Pubmed]
  9. Expression of proinflammatory cytokine mRNA in the lymphatic organs of adult and neonatal pigs. Mikami, O., Muneta, Y., Mori, Y., Yokomizo, Y., Nakajima, Y. Vet. Immunol. Immunopathol. (2002) [Pubmed]
  10. A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate. D'Cruz, O.J., Erbeck, D., Uckun, F.M. Toxicologic pathology. (2005) [Pubmed]
  11. Early cytokine response of gnotobiotic piglets to Salmonella enterica serotype typhimurium. Splíchal, I., Trebichavský, I., Muneta, Y., Mori, Y. Vet. Res. (2002) [Pubmed]
  12. Large-scale production of porcine mature interleukin-18 (IL-18) in silkworms using a hybrid baculovirus expression system. Muneta, Y., Zhao, H.K., Inumaru, S., Mori, Y. J. Vet. Med. Sci. (2003) [Pubmed]
  13. Bovine IL-18 ELISA: detection of IL-18 in sera of pregnant cow and newborn calf, and in colostrum. Muneta, Y., Yoshihara, K., Minagawa, Y., Nagata, R., Yasuyuki, M., Yamaguchi, T., Takehara, K. Journal of immunoassay & immunochemistry. (2005) [Pubmed]
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