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Gene Review

OCLN  -  occludin

Sus scrofa

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Disease relevance of OCLN


High impact information on OCLN


Biological context of OCLN


Anatomical context of OCLN


Associations of OCLN with chemical compounds

  • Immunoblot analysis indicated that occludin levels in total cell lysates as well as cytosolic, membrane (Triton-X soluble) and cytoskeletal (Triton-X insoluble) fractions remained unchanged for at least 2 hours in cells treated with 10(-7) M TPA compared to their corresponding control cells [4].
  • The mechanisms involve enhanced tyrosine phosphorylation and overexpression and possibly displacement or missorting of the junctional proteins occludin and E-cadherin [8].
  • Furthermore, we found that interleukin-1 (IL-1)beta, glutamate, hydrogen peroxide (H2O2), and sodium nitroprusside (SNP) induced the expression of mRNA for occludin and GULT1 under normoxic condition [1].
  • The expression level of occludin messenger RNA increased markedly immediately after the exposure to eicosapentaenoic acids or gamma linolenic acid [9].
  • PAO-induced occludin proteolysis could be prevented by different MMP inhibitors [10].

Other interactions of OCLN


Analytical, diagnostic and therapeutic context of OCLN


  1. Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide. Yamagata, K., Tagami, M., Takenaga, F., Yamori, Y., Itoh, S. Neurobiol. Dis. (2004) [Pubmed]
  2. ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. Moeser, A.J., Haskell, M.M., Shifflett, D.E., Little, D., Schultz, B.D., Blikslager, A.T. Gastroenterology (2004) [Pubmed]
  3. Transforming growth factor-beta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes. Grände, M., Franzen, A., Karlsson, J.O., Ericson, L.E., Heldin, N.E., Nilsson, M. J. Cell. Sci. (2002) [Pubmed]
  4. Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. Clarke, H., Soler, A.P., Mullin, J.M. J. Cell. Sci. (2000) [Pubmed]
  5. Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells. Conklin, B.S., Zhong, D.S., Zhao, W., Lin, P.H., Chen, C. J. Surg. Res. (2002) [Pubmed]
  6. Occludin as a possible determinant of tight junction permeability in endothelial cells. Hirase, T., Staddon, J.M., Saitou, M., Ando-Akatsuka, Y., Itoh, M., Furuse, M., Fujimoto, K., Tsukita, S., Rubin, L.L. J. Cell. Sci. (1997) [Pubmed]
  7. Simultaneous activation of several second messengers in hypoxia-induced hyperpermeability of brain derived endothelial cells. Fischer, S., Wiesnet, M., Marti, H.H., Renz, D., Schaper, W. J. Cell. Physiol. (2004) [Pubmed]
  8. Effects of interferon alpha-2b on barrier function and junctional complexes of renal proximal tubular LLC-PK1 cells. Lechner, J., Krall, M., Netzer, A., Radmayr, C., Ryan, M.P., Pfaller, W. Kidney Int. (1999) [Pubmed]
  9. Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells. Yamagata, K., Tagami, M., Takenaga, F., Yamori, Y., Nara, Y., Itoh, S. Neuroscience (2003) [Pubmed]
  10. Tyrosine phosphatase inhibition induces loss of blood-brain barrier integrity by matrix metalloproteinase-dependent and -independent pathways. Lohmann, C., Krischke, M., Wegener, J., Galla, H.J. Brain Res. (2004) [Pubmed]
  11. Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro. Nitz, T., Eisenblätter, T., Psathaki, K., Galla, H.J. Brain Res. (2003) [Pubmed]
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