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Gene Review

PGR  -  progesterone receptor

Canis lupus familiaris

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Disease relevance of PGR


High impact information on PGR


Chemical compound and disease context of PGR


Biological context of PGR


Anatomical context of PGR


Associations of PGR with chemical compounds

  • Steroid receptor expression was assessed by immunohistochemistry in neoplastic, hyperplastic/dysplastic, and normal mammary tissue samples removed from 68 queens and 47 bitches, using monoclonal antibodies against human oestrogen-alpha (ER) and progesterone receptors (PR) [1].
  • Fifty-nine canine mammary tumors have been simultaneously assayed for their histological nature and their content of cytosolic receptors for estradiol (ER), progesterone (PGR), and dihydrotestosterone (DHTR) [16].
  • The apparent inhibition constants for the PR and GR of MPA and PROL were compared with those of progesterone, ORG 2058, and a number of corticosteroids [17].
  • Progesterone-BSA conjugate labeled with fluorescein isothiocyanate (P-BSA-FITC) in combination with a vital stain, ethidium homodimer, was applied to visualize the presence of the progesterone receptor on living spermatozoa [14].
  • The rank order for displacement of the binding of the PR ligand [3H]ORG 2058 from the canine uterine receptor was: MPA approximately ORG 2058 > PROL > progesterone >> cortisol, dexamethasone, and spironolactone [17].

Other interactions of PGR


Analytical, diagnostic and therapeutic context of PGR


  1. Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues. Millanta, F., Calandrella, M., Bari, G., Niccolini, M., Vannozzi, I., Poli, A. Res. Vet. Sci. (2005) [Pubmed]
  2. Estrogen-alpha and progesterone receptor expression in cystic endometrial hyperplasia and pyometra in the bitch. De Bosschere, H., Ducatelle, R., Vermeirsch, H., Simoens, P., Coryn, M. Anim. Reprod. Sci. (2002) [Pubmed]
  3. Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglépristone. Bhatti, S.F., Duchateau, L., Okkens, A.C., Van Ham, L.M., Mol, J.A., Kooistra, H.S. Theriogenology (2006) [Pubmed]
  4. Effect of hormone injections on levels of cytosolic receptors for estrogen, androgen and progesterone in dog prostate. Frenette, G., Dube, J.Y., Tremblay, R.R. J. Steroid Biochem. (1982) [Pubmed]
  5. Expression of growth hormone in canine mammary tissue and mammary tumors. Evidence for a potential autocrine/paracrine stimulatory loop. van Garderen, E., de Wit, M., Voorhout, W.F., Rutteman, G.R., Mol, J.A., Nederbragt, H., Misdorp, W. Am. J. Pathol. (1997) [Pubmed]
  6. In vitro studies of canine mammary tumors: influence of 17-beta-estradiol and progesterone on cell kinetics parameters. Lespagnard, L., Kiss, R., Danguy, A., Legros, N., Lenglet, G., Devleeschouwer, N., Paridaens, R. Oncology (1987) [Pubmed]
  7. Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorigenesis in the dog. Marinelli, L., Gabai, G., Wolfswinkel, J., Mol, J.A. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
  8. Induction of the acrosome reaction in dog sperm cells is dependent on epididymal maturation: the generation of a functional progesterone receptor is involved. Sirivaidyapong, S., Bevers, M.M., Gadella, B.M., Colenbrander, B. Mol. Reprod. Dev. (2001) [Pubmed]
  9. Effects of aglépristone, a progesterone receptor antagonist, administered during the early luteal phase in non-pregnant bitches. Galac, S., Kooistra, H.S., Dieleman, S.J., Cestnik, V., Okkens, A.C. Theriogenology (2004) [Pubmed]
  10. Serum estradiol-17 beta, progesterone and respective uterine cytosol receptor concentrations in bitches with spontaneous pyometra. Ververidis, H.N., Boscos, C.M., Stefanakis, A., Saratsis, P., Stamou, A.I., Krambovitis, E. Theriogenology (2004) [Pubmed]
  11. Induction of parturition in the bitch with the progesterone-receptor blocker aglépristone. Baan, M., Taverne, M.A., Kooistra, H.S., de Gier, J., Dieleman, S.J., Okkens, A.C. Theriogenology (2005) [Pubmed]
  12. Cloning and cellular localization of the canine progesterone receptor: co-localization with growth hormone in the mammary gland. Lantinga-van Leeuwen, I.S., van Garderen, E., Rutteman, G.R., Mol, J.A. J. Steroid Biochem. Mol. Biol. (2000) [Pubmed]
  13. Hormonal regulation of cytoplasmic estrogen and progesterone receptors in the beagle uterus and oviduct. Lessey, B.A., Wahawisan, R., Gorell, T.A. Mol. Cell. Endocrinol. (1981) [Pubmed]
  14. Acrosome reaction in dog sperm is induced by a membrane-localized progesterone receptor. Sirivaidyapong, S., Bevers, M.M., Colenbrander, B. J. Androl. (1999) [Pubmed]
  15. The effects of endometrial scarification on uterine steroid receptors, bacterial flora and histological structure in the bitch. Dhaliwal, G.K., England, G.C., Noakes, D.E. Anim. Reprod. Sci. (2002) [Pubmed]
  16. Simultaneous occurrence of receptors for estradiol, progesterone, and dihydrotestosterone in canine mammary tumors. Elling, H., Ungemach, F.R. J. Cancer Res. Clin. Oncol. (1983) [Pubmed]
  17. Binding specificity of medroxyprogesterone acetate and proligestone for the progesterone and glucocorticoid receptor in the dog. Selman, P.J., Wolfswinkel, J., Mol, J.A. Steroids (1996) [Pubmed]
  18. A prospective analysis of immunohistochemically determined estrogen receptor alpha and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog. de Las Mulas, J.M., Millán, Y., Dios, R. Vet. Pathol. (2005) [Pubmed]
  19. Termination of mid-gestation pregnancy in bitches with aglepristone, a progesterone receptor antagonist. Galac, S., Kooistra, H.S., Butinar, J., Bevers, M.M., Dieleman, S.J., Voorhout, G., Okkens, A.C. Theriogenology (2000) [Pubmed]
  20. Comparison of estrogen and progesterone receptor expression in normal and tumor mammary tissues from dogs. Donnay, I., Rauïs, J., Devleeschouwer, N., Wouters-Ballman, P., Leclercq, G., Verstegen, J. Am. J. Vet. Res. (1995) [Pubmed]
  21. Cytoplasmic estrogen and progesterone receptors in canine endometrium during the estrous cycle. Johnston, S.D., Kiang, D.T., Seguin, B.E., Hegstad, R.L. Am. J. Vet. Res. (1985) [Pubmed]
  22. Assignment of progesterone receptor (PGR) to canine chromosome band 21q1.2 by in situ hybridization. Zijlstra, C., De Haan, N.A., Lantinga-Van Leeuwen, I.S., Mol, J.A., Bosma, A.A. Cytogenet. Cell Genet. (2001) [Pubmed]
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