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Gene Review

ESR1  -  estrogen receptor 1

Canis lupus familiaris

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Disease relevance of ESR1


High impact information on ESR1


Chemical compound and disease context of ESR1


Biological context of ESR1


Anatomical context of ESR1

  • Based on overall staining intensity there appeared to be a higher concentration of ER in the urethra than in the prostate [14].
  • In the normal prostate, specific immunocytochemical ER staining was confined to nuclei of the prostatic stroma and prostatic ductal epithelium [14].
  • We have used the monoclonal estrogen receptor (ER) antibody H222Sp gamma to localize ER by immunocytochemistry in frozen sections of the normal canine urinary tract of both sexes and of the normal prostate of the male [14].
  • In addition to this action, these anti-oestrogens are known to inhibit some types of plasma membrane ion channels and other proteins through mechanisms that do not appear to involve their interactions with the estrogen receptor but could be the result of their effect on membrane lipid structure or fluidity [15].
  • In contrast, the basal glands from uteri of CHE group dogs contained more estrogen receptor than glands from normal dogs at the same stage of estrous cycle [16].

Associations of ESR1 with chemical compounds

  • Pretreatment with the estrogen-receptor antagonist faslodex (ICI 182,780) did not alter estrogen-induced infarct-limiting and antiarrhythmic effects [4].
  • PROCEDURE: ER were detected in formalin-fixed tissues, using an avidin-biotin alkaline phosphatase IHC assay and were quantified on fresh-frozen tumor samples, using a modified dextran-coated charcoal (DCC) assay [17].
  • The clonal line which contained measurable ER, had a shift in colony-size distribution to smaller colonies when exposed to tamoxifen or tamoxifen with estradiol that may have been estrogen-receptor mediated [18].
  • These effects were partially attenuated by pretreatment with either L-NAME or wortmannin and were completely abolished by ICI182780 (an estrogen receptor antagonist) or L-NAME plus charybdotoxin (a blocker of Ca-activated K channels) [10].
  • The number of uterine estrogen receptor and their mRNA levels for ovariectomized bitches were low, but increased (P < 0.05) after treatment with a low dose of estradiol benzoate [12].

Other interactions of ESR1

  • A prospective analysis of immunohistochemically determined estrogen receptor alpha and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog [19].

Analytical, diagnostic and therapeutic context of ESR1


  1. Androgen and prostatic stroma. Niu, Y.J., Ma, T.X., Zhang, J., Xu, Y., Han, R.F., Sun, G. Asian J. Androl. (2003) [Pubmed]
  2. Androgen- and estrogen-receptor content in spontaneous and experimentally induced canine prostatic hyperplasia. Trachtenberg, J., Hicks, L.L., Walsh, P.C. J. Clin. Invest. (1980) [Pubmed]
  3. Mechanisms of estrogen-induced vasodilation: in vivo studies in canine coronary conductance and resistance arteries. Sudhir, K., Chou, T.M., Mullen, W.L., Hausmann, D., Collins, P., Yock, P.G., Chatterjee, K. J. Am. Coll. Cardiol. (1995) [Pubmed]
  4. Differential effects of sarcolemmal and mitochondrial K(ATP) channels activated by 17 beta-estradiol on reperfusion arrhythmias and infarct sizes in canine hearts. Tsai, C.H., Su, S.F., Chou, T.F., Lee, T.M. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  5. Thirteen-week oral toxicity study of difluoromethylornithine in combination with tamoxifen citrate in female dogs. Brown, A.P., Morrissey, R.L., Crowell, J.A., Levine, B.S. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  6. Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Chou, T.M., Sudhir, K., Hutchison, S.J., Ko, E., Amidon, T.M., Collins, P., Chatterjee, K. Circulation (1996) [Pubmed]
  7. Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart. Ogita, H., Node, K., Asanuma, H., Sanada, S., Liao, Y., Takashima, S., Asakura, M., Mori, H., Shinozaki, Y., Hori, M., Kitakaze, M. J. Am. Coll. Cardiol. (2002) [Pubmed]
  8. Receptors for epidermal growth factor and estradiol in canine mammary tumors. Nerurkar, V.R., Seshadri, R., Mulherkar, R., Ishwad, C.S., Lalitha, V.S., Naik, S.N. Int. J. Cancer (1987) [Pubmed]
  9. Spontaneous basaloid adenomas of the mammary gland in four dogs: clinicopathologic and immunohistochemical features. Martín de las Mulas, E., Ordás, J., Millán, M.Y., Espinosa de los Monteros, A., Reymundo, C. Vet. Pathol. (2002) [Pubmed]
  10. Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: role of phosphatidylinositol 3-kinase/Akt pathway. Ogita, H., Node, K., Asanuma, H., Sanada, S., Kim, J., Takashima, S., Minamino, T., Hori, M., Kitakaze, M. J. Cardiovasc. Pharmacol. (2004) [Pubmed]
  11. Expression of estrogen receptor alpha and beta genes in the mediobasal hypothalamus, pituitary and ovary during the canine estrous cycle. Hatoya, S., Torii, R., Kumagai, D., Sugiura, K., Kawate, N., Tamada, H., Sawada, T., Inaba, T. Neurosci. Lett. (2003) [Pubmed]
  12. Increased LH pulse frequency and estrogen secretion associated with termination of anestrus followed by enhancement of uterine estrogen receptor gene expression in the beagle bitch. Tani, H., Inaba, T., Nonami, M., Matsuyama, S., Takamori, Y., Torii, R., Tamada, H., Kawate, N., Sawada, T. Theriogenology (1999) [Pubmed]
  13. Immunohistochemical detection of androgen receptors in the canine uterus throughout the estrus cycle. Vermeirsch, H., Van den Broeck, W., Coryn, M., Simoens, P. Theriogenology (2002) [Pubmed]
  14. Immunocytochemical localization of estrogen receptors in the normal male and female canine urinary tract and prostate. Schulze, H., Barrack, E.R. Endocrinology (1987) [Pubmed]
  15. Effects of anti-oestrogens and beta-estradiol on calcium uptake by cardiac sarcoplasmic reticulum. Dodds, M.L., Kargacin, M.E., Kargacin, G.J. Br. J. Pharmacol. (2001) [Pubmed]
  16. Immunohistochemical analysis of estrogen receptors in cystic-endometritis-pyometra complex in the bitch. De Cock, H., Vermeirsch, H., Ducatelle, R., De Schepper, J. Theriogenology (1997) [Pubmed]
  17. Immunohistochemical assay for detecting estrogen receptors in canine mammary tumors. Graham, J.C., O'Keefe, D.A., Gelberg, H.B. Am. J. Vet. Res. (1999) [Pubmed]
  18. Heterogenic properties of clonal cell lines derived from canine mammary carcinomas and sensitivity to tamoxifen and doxorubicin. Sartin, E.A., Barnes, S., Toivio-Kinnucan, M., Wright, J.C., Wolfe, L.G. Anticancer Res. (1993) [Pubmed]
  19. A prospective analysis of immunohistochemically determined estrogen receptor alpha and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog. de Las Mulas, J.M., Millán, Y., Dios, R. Vet. Pathol. (2005) [Pubmed]
  20. Identification of phytoestrogens in the urine of male dogs. Juniewicz, P.E., Pallante Morell, S., Moser, A., Ewing, L.L. J. Steroid Biochem. (1988) [Pubmed]
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