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Gene Review

MGST2  -  microsomal glutathione S-transferase 2

Homo sapiens

Synonyms: GST2, MGST-II, Microsomal GST-2, Microsomal GST-II, Microsomal glutathione S-transferase 2
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Disease relevance of MGST2


High impact information on MGST2


Biological context of MGST2


Anatomical context of MGST2


Associations of MGST2 with chemical compounds


Other interactions of MGST2


Analytical, diagnostic and therapeutic context of MGST2


  1. A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. Yan, K.L., Zhang, X.J., Wang, Z.M., Yang, S., Zhang, G.L., Wang, J., Xiao, F.L., Gao, M., Cui, Y., Chen, J.J., Fan, X., Sun, L.D., Xia, Q., Zhang, K.Y., Niu, Z.M., Xu, S.J., Tzschach, A., Ropers, H., Huang, W., Liu, J.J. J. Invest. Dermatol. (2006) [Pubmed]
  2. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. Jakobsson, P.J., Mancini, J.A., Riendeau, D., Ford-Hutchinson, A.W. J. Biol. Chem. (1997) [Pubmed]
  3. Aberrant expression of active leukotriene C(4) synthase in CD16(+) neutrophils from patients with chronic myeloid leukemia. Sjölinder, M., Stenke, L., Näsman-Glaser, B., Widell, S., Doucet, J., Jakobsson, P.J., Lindgren, J.A. Blood (2000) [Pubmed]
  4. Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. Scoggan, K.A., Jakobsson, P.J., Ford-Hutchinson, A.W. J. Biol. Chem. (1997) [Pubmed]
  5. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. Sjöström, M., Jakobsson, P.J., Heimburger, M., Palmblad, J., Haeggström, J.Z. Eur. J. Biochem. (2001) [Pubmed]
  6. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. Jakobsson, P.J., Mancini, J.A., Ford-Hutchinson, A.W. J. Biol. Chem. (1996) [Pubmed]
  7. Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to the vicinity of the d locus on mouse chromosome 9. Kasahara, M., Matsumura, E., Webb, G., Board, P.G., Figueroa, F., Klein, J. Genomics (1990) [Pubmed]
  8. Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan. Harkey, M.A., Czerwinski, M., Slattery, J., Kiem, H.P. Cancer Invest. (2005) [Pubmed]
  9. Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult. Goswami, S., Sheets, N.L., Zavadil, J., Chauhan, B.K., Bottinger, E.P., Reddy, V.N., Kantorow, M., Cvekl, A. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
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