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Gene Review

Lrp1  -  low density lipoprotein receptor-related...

Rattus norvegicus

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Disease relevance of Lrp1


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Biological context of Lrp1


Anatomical context of Lrp1


Associations of Lrp1 with chemical compounds


Regulatory relationships of Lrp1


Other interactions of Lrp1


  1. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Bu, G., Williams, S., Strickland, D.K., Schwartz, A.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Liu, Y., Jones, M., Hingtgen, C.M., Bu, G., Laribee, N., Tanzi, R.E., Moir, R.D., Nath, A., He, J.J. Nat. Med. (2000) [Pubmed]
  3. Enhanced macrophage resistance to Pseudomonas exotoxin A is correlated with decreased expression of the low-density lipoprotein receptor-related protein. Laithwaite, J.E., Benn, S.J., Yamate, J., FitzGerald, D.J., LaMarre, J. Infect. Immun. (1999) [Pubmed]
  4. Expression of hepatocyte low-density lipoprotein receptor-related protein is post-transcriptionally regulated by extracellular matrix. Schmoelzl, S., Benn, S.J., Laithwaite, J.E., Greenwood, S.J., Marshall, W.S., Munday, N.A., FitzGerald, D.J., LaMarre, J. Lab. Invest. (1998) [Pubmed]
  5. Decreased expression of the low-density lipoprotein receptor-related protein-1 (LRP-1) in rats with prostate cancer. Gilardoni, M.B., Ceschin, D.G., Sahores, M.M., Oviedo, M., Gehrau, R.C., Chiabrando, G.A. J. Histochem. Cytochem. (2003) [Pubmed]
  6. The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo. Warshawsky, I., Bu, G., Mast, A., Saffitz, J.E., Broze, G.J., Schwartz, A.L. J. Clin. Invest. (1995) [Pubmed]
  7. The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor. Warshawsky, I., Broze, G.J., Schwartz, A.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Orth, K., Madison, E.L., Gething, M.J., Sambrook, J.F., Herz, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Human alpha-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Nassar, T., Akkawi, S., Bar-Shavit, R., Haj-Yehia, A., Bdeir, K., Al-Mehdi, A.B., Tarshis, M., Higazi, A.A. Blood (2002) [Pubmed]
  10. Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells. Bu, G., Maksymovitch, E.A., Schwartz, A.L. J. Biol. Chem. (1993) [Pubmed]
  11. Uptake, internalization and degradation of the novel plasminogen activator reteplase (BM 06.022) in the rat. Kuiper, J., van de Bilt, H., Martin, U., van Berkel, T.J. Thromb. Haemost. (1995) [Pubmed]
  12. Gamma-secretase is a functional component of phagosomes. Jutras, I., Laplante, A., Boulais, J., Brunet, S., Thinakaran, G., Desjardins, M. J. Biol. Chem. (2005) [Pubmed]
  13. Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules. Ranganathan, S., Liu, C.X., Migliorini, M.M., Von Arnim, C.A., Peltan, I.D., Mikhailenko, I., Hyman, B.T., Strickland, D.K. J. Biol. Chem. (2004) [Pubmed]
  14. Recycling of apolipoprotein E and lipoprotein lipase through endosomal compartments in vivo. Heeren, J., Grewal, T., Jäckle, S., Beisiegel, U. J. Biol. Chem. (2001) [Pubmed]
  15. Inhibition of mannose receptor-mediated clearance of tissue-type plasminogen activator (t-PA) by dextran: a new explanation for its antithrombotic effect. Noorman, F., Barrett-Bergshoeff, M.M., Bekkers, M., Emeis, J.J., Rijken, D.C. Thromb. Haemost. (1997) [Pubmed]
  16. LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells. Azhar, S., Medicherla, S., Shen, W.J., Fujioka, Y., Fong, L.G., Reaven, E., Cooper, A.D. J. Lipid Res. (2006) [Pubmed]
  17. The 39-kDa protein regulates LRP activity in cultured endothelial and smooth muscle cells. Warshawsky, I., Schwartz, A.L. Eur. J. Cell Biol. (1996) [Pubmed]
  18. Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis. Benchenane, K., Berezowski, V., Ali, C., Fernández-Monreal, M., López-Atalaya, J.P., Brillault, J., Chuquet, J., Nouvelot, A., MacKenzie, E.T., Bu, G., Cecchelli, R., Touzani, O., Vivien, D. Circulation (2005) [Pubmed]
  19. Epidermal growth factor and platelet-derived growth factor-BB induce a stable increase in the activity of low density lipoprotein receptor-related protein in vascular smooth muscle cells by altering receptor distribution and recycling. Weaver, A.M., McCabe, M., Kim, I., Allietta, M.M., Gonias, S.L. J. Biol. Chem. (1996) [Pubmed]
  20. alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. Qiu, Z., Strickland, D.K., Hyman, B.T., Rebeck, G.W. J. Biol. Chem. (2002) [Pubmed]
  21. Effect of apolipoprotein C-I peptides on the apolipoprotein E content and receptor-binding properties of beta-migrating very low density lipoproteins. Swaney, J.B., Weisgraber, K.H. J. Lipid Res. (1994) [Pubmed]
  22. The betaA4 amyloid peptide complexes to and enhances the uptake of beta-very low density lipoproteins by the low density lipoprotein receptor-related protein and heparan sulfate proteoglycans pathway. Scharnagl, H., Tisljar, U., Winkler, K., Hüttinger, M., Nauck, M.A., Gross, W., Wieland, H., Ohm, T.G., März, W. Lab. Invest. (1999) [Pubmed]
  23. Characterization of newly established tumor lines from a spontaneous malignant schwannoma in F344 rats: nerve growth factor production, growth inhibition by transforming growth factor-beta1, and macrophage-like phenotype expression. Yamate, J., Yasui, H., Benn, S.J., Tsukamoto, Y., Kuwamura, M., Kumagai, D., Sakuma, S., LaMarre, J. Acta Neuropathol. (2003) [Pubmed]
  24. Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2. Stefansson, S., Lawrence, D.A., Argraves, W.S. J. Biol. Chem. (1996) [Pubmed]
  25. Different zonal distribution of the asialoglycoprotein receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein and the lipoprotein-remnant receptor of rat liver parenchymal cells. Voorschuur, A.H., Kuiper, J., Neelissen, J.A., Boers, W., Van Berkel, T.J. Biochem. J. (1994) [Pubmed]
  26. Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. Frøyland, L., Vaagenes, H., Asiedu, D.K., Garras, A., Lie, O., Berge, R.K. Lipids (1996) [Pubmed]
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