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Gene Review

MYP2  -  myopia 2 (high grade, autosomal dominant)

Homo sapiens

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Disease relevance of MYP2


High impact information on MYP2


Biological context of MYP2

  • Recently, the transforming growth beta-induced factor (TGIF) gene was reported to be a candidate gene for MYP2-associated high myopia in single-nucleotide polymorphism studies [6].
  • Mutation analysis of the encoded TGIF gene for MYP2 autosomal dominant high myopia did not identify sequence alterations associated with the disease phenotype [6].
  • A genomic interval of 2.2 centiMorgans (cM) was defined on chromosome band 18p11.31 using 7 families diagnosed with autosomal dominant high myopia and was designated the MYP2 locus [9].
  • Further refinement of the MYP2 locus for autosomal dominant high myopia by linkage disequilibrium analysis [10].
  • METHODS: A physical map of a contracted MYP2 interval was compiled, and gene expression studies in ocular tissues using complementary DNA library screens, microarray matches, and reverse-transcription techniques aided in prioritizing gene selection for screening [11].

Anatomical context of MYP2


Associations of MYP2 with chemical compounds

  • METHOD: In the setting of a tertiary referral center, patients with pathologic myopia in whom fluorescein and conventional ICG angiography demonstrated distinct CNV vessels supplying the subfoveal neovascular complex were submitted to focal ingrowth site treatment using a new therapeutic modality termed ICG-mediated photothrombosis [17].
  • The authors performed a prospective study of 36 eyes affected by pathologic myopia with macular subretinal neovascularization (SRNV) successfully treated with either argon green, dye orange (590 nm), or krypton red lasers [18].

Other interactions of MYP2


Analytical, diagnostic and therapeutic context of MYP2


  1. Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia. Zhou, J., Young, T.L. Gene (2005) [Pubmed]
  2. Verteporfin therapy of subfoveal choroidal neovascularization in pathologic myopia: 2-year results of a randomized clinical trial--VIP report no. 3. Blinder, K.J., Blumenkranz, M.S., Bressler, N.M., Bressler, S.B., Donato, G., Lewis, H., Lim, J.I., Menchini, U., Miller, J.W., Mones, J.M., Potter, M.J., Pournaras, C., Reaves, A., Rosenfeld, P., Schachat, A.P., Schmidt-Erfurth, U., Sickenberg, M., Singerman, L.J., Slakter, J.S., Strong, H.A., Virgili, G., Williams, G.A. Ophthalmology (2003) [Pubmed]
  3. A preliminary study of photodynamic therapy using verteporfin for choroidal neovascularization in pathologic myopia, ocular histoplasmosis syndrome, angioid streaks, and idiopathic causes. Sickenberg, M., Schmidt-Erfurth, U., Miller, J.W., Pournaras, C.J., Zografos, L., Piguet, B., Donati, G., Laqua, H., Barbazetto, I., Gragoudas, E.S., Lane, A.M., Birngruber, R., van den Bergh, H., Strong, H.A., Manjuris, U., Gray, T., Fsadni, M., Bressler, N.M. Arch. Ophthalmol. (2000) [Pubmed]
  4. Causative factors of retinal detachment in macular holes. Morita, H., Ideta, H., Ito, K., Yonemoto, J., Sasaki, K., Tanaka, S. Retina (Philadelphia, Pa.) (1991) [Pubmed]
  5. Unilateral macular retinoschisis with stellate foveal appearance in two females with myopia. Menchini, U., Brancato, R., Virgili, G., Pierro, L. Ophthalmic surgery and lasers. (2000) [Pubmed]
  6. Sequence variants in the transforming growth beta-induced factor (TGIF) gene are not associated with high myopia. Scavello, G.S., Paluru, P.C., Ganter, W.R., Young, T.L. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  7. Regulatory aspects of drug approval for macular degeneration. Gryziewicz, L. Adv. Drug Deliv. Rev. (2005) [Pubmed]
  8. Physiologic vs pathologic myopia: genetics vs environment. Curtin, B.J. Ophthalmology (1979) [Pubmed]
  9. Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes. Scavello, G.S., Paluru, P.C., Zhou, J., White, P.S., Rappaport, E.F., Young, T.L. Mol. Vis. (2005) [Pubmed]
  10. Further refinement of the MYP2 locus for autosomal dominant high myopia by linkage disequilibrium analysis. Young, T.L., Atwood, L.D., Ronan, S.M., Dewan, A.T., Alvear, A.B., Peterson, J., Holleschau, A., King, R.A. Ophthalmic Genet. (2001) [Pubmed]
  11. Dissecting the genetics of human high myopia: a molecular biologic approach. Young, T.L. Transactions of the American Ophthalmological Society. (2004) [Pubmed]
  12. Lacquer crack lesions in experimental chick myopia. Hirata, A., Negi, A. Graefes Arch. Clin. Exp. Ophthalmol. (1998) [Pubmed]
  13. Familial pathologic myopia, corneal dystrophy, and deafness: a new syndrome. Kurt, E., Günen, A., Sadikoğlu, Y., Oztürk, F., Tarhan, S., Sari, R.A., Fistik, T., Ari, Z. Jpn. J. Ophthalmol. (2001) [Pubmed]
  14. Peripapillary detachment in pathologic myopia. Freund, K.B., Ciardella, A.P., Yannuzzi, L.A., Pece, A., Goldbaum, M., Kokame, G.T., Orlock, D. Arch. Ophthalmol. (2003) [Pubmed]
  15. Indocyanine green fundus angiography of retrobulbar vasculature. Mutoh, T., Sakurai, M., Tamai, M. Arch. Ophthalmol. (1995) [Pubmed]
  16. Clinicopathologic study after submacular removal of choroidal neovascular membranes treated with verteporfin ocular photodynamic therapy. Moshfeghi, D.M., Kaiser, P.K., Grossniklaus, H.E., Sternberg, P., Sears, J.E., Johnson, M.W., Ratliff, N., Branco, A., Blumenkranz, M.S., Lewis, H. Am. J. Ophthalmol. (2003) [Pubmed]
  17. Selective occlusion of subfoveal choroidal neovascularization in pathologic myopia using a new technique of ingrowth site treatment. Costa, R.A., Calucci, D., Teixeira, L.F., Cardillo, J.A., Bonomo, P.P. Am. J. Ophthalmol. (2003) [Pubmed]
  18. Photocoagulation scar expansion after laser therapy for choroidal neovascularization in degenerative myopia. Brancato, R., Pece, A., Avanza, P., Radrizzani, E. Retina (Philadelphia, Pa.) (1990) [Pubmed]
  19. Photodynamic Therapy vs Limited Macular Translocation in the Management of Subfoveal Choroidal Neovascularization in Pathologic Myopia: A Two-year Study. Glacet-Bernard, A., Benyelles, N., Dumas, S., Haddad, W.M., Voigt, M., Razavi, S., Roquet, W., Coscas, G., Soubrane, G. Am. J. Ophthalmol. (2007) [Pubmed]
  20. Prolidase deficiency associated with pathologic myopia. Kiratli, H., Satilmiş, M. Ophthalmic Genet. (1998) [Pubmed]
  21. Retinal and optic nerve diseases. Margalit, E., Sadda, S.R. Artificial organs. (2003) [Pubmed]
  22. Laser photocoagulation for choroidal neovascularisation in pathologic myopia. Virgili, G., Menchini, F. Cochrane database of systematic reviews (Online) (2005) [Pubmed]
  23. Optical coherence tomography after photodynamic therapy for patients with pathologic myopia. Karacorlu, S.A., Ozdemir, H., Senturk, F., Karacorlu, M. Retina (Philadelphia, Pa.) (2006) [Pubmed]
  24. Indocyanine green angiography in high myopia. Axer-Siegel, R., Cotlear, D., Priel, E., Rosenblatt, I., Snir, M., Weinberger, D. Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye. (2004) [Pubmed]
  25. Upper eyelid retraction after retinal detachment repair. Mauriello, J.A., Palydowycz, S.B. Ophthalmic surgery. (1993) [Pubmed]
  26. Incidence of retinal detachment following clear-lens extraction in myopic patients. Retrospective analysis. Barraquer, C., Cavelier, C., Mejía, L.F. Arch. Ophthalmol. (1994) [Pubmed]
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