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MeSH Review

Bruch Membrane

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Disease relevance of Bruch Membrane


High impact information on Bruch Membrane


Chemical compound and disease context of Bruch Membrane


Biological context of Bruch Membrane


Anatomical context of Bruch Membrane


Associations of Bruch Membrane with chemical compounds


Gene context of Bruch Membrane


Analytical, diagnostic and therapeutic context of Bruch Membrane


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  2. Tissue inhibitor of metalloproteinases-3 is a component of Bruch's membrane of the eye. Fariss, R.N., Apte, S.S., Olsen, B.R., Iwata, K., Milam, A.H. Am. J. Pathol. (1997) [Pubmed]
  3. Experiments on the absorption of argon and krypton laser by blood. Folk, J.C., Shortt, S.G., Kleiber, P.D. Ophthalmology (1985) [Pubmed]
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  5. Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum. Gorgels, T.G., Hu, X., Scheffer, G.L., van der Wal, A.C., Toonstra, J., de Jong, P.T., van Kuppevelt, T.H., Levelt, C.N., de Wolf, A., Loves, W.J., Scheper, R.J., Peek, R., Bergen, A.A. Hum. Mol. Genet. (2005) [Pubmed]
  6. Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells. Hageman, G.S., Mullins, R.F., Russell, S.R., Johnson, L.V., Anderson, D.H. FASEB J. (1999) [Pubmed]
  7. Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations. Klenotic, P.A., Munier, F.L., Marmorstein, L.Y., Anand-Apte, B. J. Biol. Chem. (2004) [Pubmed]
  8. Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model. Tobe, T., Ortega, S., Luna, J.D., Ozaki, H., Okamoto, N., Derevjanik, N.L., Vinores, S.A., Basilico, C., Campochiaro, P.A. Am. J. Pathol. (1998) [Pubmed]
  9. Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier. Gehlbach, P., Demetriades, A.M., Yamamoto, S., Deering, T., Xiao, W.H., Duh, E.J., Yang, H.S., Lai, H., Kovesdi, I., Carrion, M., Wei, L., Campochiaro, P.A. Hum. Gene Ther. (2003) [Pubmed]
  10. Evolution of age-related macular degeneration with choroidal perfusion abnormality. Piguet, B., Palmvang, I.B., Chisholm, I.H., Minassian, D., Bird, A.C. Am. J. Ophthalmol. (1992) [Pubmed]
  11. The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam eye study. Klein, R., Klein, B.E., Tomany, S.C., Cruickshanks, K.J. Ophthalmology (2003) [Pubmed]
  12. Analysis of the collagen VI assemblies associated with Sorsby's fundus dystrophy. Knupp, C., Chong, N.H., Munro, P.M., Luthert, P.J., Squire, J.M. J. Struct. Biol. (2002) [Pubmed]
  13. The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas. Yamada, Y., Ishibashi, K., Ishibashi, K., Bhutto, I.A., Tian, J., Lutty, G.A., Handa, J.T. Exp. Eye Res. (2006) [Pubmed]
  14. Bruch membrane aging alters the gene expression profile of human retinal pigment epithelium. Cai, H., Del Priore, L.V. Curr. Eye Res. (2006) [Pubmed]
  15. Effects of extracellular matrix and Bruch's membrane on retinal outer segment phagocytosis by cultured human retinal pigment epithelium. Miceli, M.V., Newsome, D.A. Curr. Eye Res. (1996) [Pubmed]
  16. Lipids of human retina, retinal pigment epithelium, and Bruch's membrane/choroid: comparison of macular and peripheral regions. Gülcan, H.G., Alvarez, R.A., Maude, M.B., Anderson, R.E. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  17. Ultrastructural immunocytochemical localization of chondroitin sulfate proteoglycan in Bruch's membrane of the rat. Lin, W.L., Essner, E., McCarthy, K.J., Couchman, J.R. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  18. The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing light microscopy. Haimovici, R., Gantz, D.L., Rumelt, S., Freddo, T.F., Small, D.M. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  19. Cell injury unmasks a latent proangiogenic phenotype in mice with increased expression of FGF2 in the retina. Yamada, H., Yamada, E., Kwak, N., Ando, A., Suzuki, A., Esumi, N., Zack, D.J., Campochiaro, P.A. J. Cell. Physiol. (2000) [Pubmed]
  20. Blood-retinal barrier dysfunction at the pigment epithelium induced by blue light. Putting, B.J., Zweypfenning, R.C., Vrensen, G.F., Oosterhuis, J.A., van Best, J.A. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  21. Accumulation of cholesterol with age in human Bruch's membrane. Curcio, C.A., Millican, C.L., Bailey, T., Kruth, H.S. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  22. Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion. McLaughlin, B.J., Fan, W., Zheng, J.J., Cai, H., Del Priore, L.V., Bora, N.S., Kaplan, H.J. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  23. RPE destruction causes choriocapillary atrophy. Korte, G.E., Reppucci, V., Henkind, P. Invest. Ophthalmol. Vis. Sci. (1984) [Pubmed]
  24. Increase in the advanced glycation end product pentosidine in Bruch's membrane with age. Handa, J.T., Verzijl, N., Matsunaga, H., Aotaki-Keen, A., Lutty, G.A., te Koppele, J.M., Miyata, T., Hjelmeland, L.M. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  25. Components of the plasminogen activation system in uveal melanoma--a clinico-pathological study. De Vries, T.J., Mooy, C.M., Van Balken, M.R., Luyten, G.P., Quax, P.H., Verspaget, H.W., Weidle, U.H., Ruiter, D.J., Van Muijen, G.N. J. Pathol. (1995) [Pubmed]
  26. Evaluation of the gene encoding the tissue inhibitor of metalloproteinases-3 in various maculopathies. Felbor, U., Doepner, D., Schneider, U., Zrenner, E., Weber, B.H. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  27. Age-dependent variation in metalloproteinase activity of isolated human Bruch's membrane and choroid. Guo, L., Hussain, A.A., Limb, G.A., Marshall, J. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  28. A mouse model for Sorsby fundus dystrophy. Weber, B.H., Lin, B., White, K., Kohler, K., Soboleva, G., Herterich, S., Seeliger, M.W., Jaissle, G.B., Grimm, C., Reme, C., Wenzel, A., Asan, E., Schrewe, H. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  29. The extracellular matrix of human retinal pigment epithelial cells in vivo and its synthesis in vitro. Campochiaro, P.A., Jerdon, J.A., Glaser, B.M. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  30. Altered synthesis of Bruch's membrane proteoglycans associated with dominant retinitis pigmentosa. Hewitt, A.T., Newsome, D.A. Curr. Eye Res. (1985) [Pubmed]
  31. Transplantation of cultured human retinal epithelium to Bruch's membrane of the owl monkey's eye. Gouras, P., Flood, M.T., Kjedbye, H., Bilek, M.K., Eggers, H. Curr. Eye Res. (1985) [Pubmed]
  32. Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid. Vranka, J.A., Johnson, E., Zhu, X., Shepardson, A., Alexander, J.P., Bradley, J.M., Wirtz, M.K., Weleber, R.G., Klein, M.L., Acott, T.S. Curr. Eye Res. (1997) [Pubmed]
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