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Gene Review

SEC62  -  SEC62 homolog (S. cerevisiae)

Homo sapiens

Synonyms: Dtrp1, HTP1, TLOC1, TP-1, Translocation protein 1, ...
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Disease relevance of TLOC1


Psychiatry related information on TLOC1


High impact information on TLOC1


Chemical compound and disease context of TLOC1


Biological context of TLOC1


Anatomical context of TLOC1


Associations of TLOC1 with chemical compounds


Physical interactions of TLOC1


Other interactions of TLOC1


Analytical, diagnostic and therapeutic context of TLOC1


  1. Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer. Jung, V., Kindich, R., Kamradt, J., Jung, M., Müller, M., Schulz, W.A., Engers, R., Unteregger, G., Stöckle, M., Zimmermann, R., Wullich, B. Mol. Cancer Res. (2006) [Pubmed]
  2. Letter: Translocation of the Philadelphia chromosome onto the 17 short arm in chronic myeloid leukemia: a second example. Engle, E., McGee, B.J., Flexner, J.M., Krantz, S.B. N. Engl. J. Med. (1975) [Pubmed]
  3. Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites. Francés, R., Muñoz, C., Zapater, P., Uceda, F., Gascón, I., Pascual, S., Pérez-Mateo, M., Such, J. Gut (2004) [Pubmed]
  4. Protein Kinase C-Dependent Mitochondrial Translocation of Proapoptotic Protein Bax on Activation of Inducible Nitric-Oxide Synthase in Rostral Ventrolateral Medulla Mediates Cardiovascular Depression during Experimental Endotoxemia. Chan, J.Y., Chang, A.Y., Wang, L.L., Ou, C.C., Chan, S.H. Mol. Pharmacol. (2007) [Pubmed]
  5. Bacterial translocation of enteric organisms in patients with cirrhosis. Cirera, I., Bauer, T.M., Navasa, M., Vila, J., Grande, L., Taurá, P., Fuster, J., García-Valdecasas, J.C., Lacy, A., Suárez, M.J., Rimola, A., Rodés, J. J. Hepatol. (2001) [Pubmed]
  6. The Role of Myosin II Motor Activity in Distributing Myosin Asymmetrically and Coupling Protrusive Activity to Cell Translocation. Kolega, J. Mol. Biol. Cell (2006) [Pubmed]
  7. Reverse Translocation of tRNA in the Ribosome. Shoji, S., Walker, S.E., Fredrick, K. Mol. Cell (2006) [Pubmed]
  8. Gradual Translocation of Spatial Correlates of Neuronal Firing in the Hippocampus toward Prospective Reward Locations. Lee, I., Griffin, A.L., Zilli, E.A., Eichenbaum, H., Hasselmo, M.E. Neuron (2006) [Pubmed]
  9. Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes. Tyedmers, J., Lerner, M., Bies, C., Dudek, J., Skowronek, M.H., Haas, I.G., Heim, N., Nastainczyk, W., Volkmer, J., Zimmermann, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  10. Protein Kinase A-dependent Translocation of Hsp90{alpha} Impairs Endothelial Nitric-oxide Synthase Activity in High Glucose and Diabetes. Lei, H., Venkatakrishnan, A., Yu, S., Kazlauskas, A. J. Biol. Chem. (2007) [Pubmed]
  11. Evidence for Actin Cytoskeleton-dependent and -independent Pathways for RelA/p65 Nuclear Translocation in Endothelial Cells. Fazal, F., Minhajuddin, M., Bijli, K.M., McGrath, J.L., Rahman, A. J. Biol. Chem. (2007) [Pubmed]
  12. Differential expression of protein kinase C isoforms in glial and neuronal cells. Translocation and down-regulation of PKC isoforms in C6 glioma and NG 108-15 hybrid cells: effects of extracellular Ca(2+)-depletion. Chen, C.C., Chang, J., Lin, W.W. Neurochem. Int. (1995) [Pubmed]
  13. Protein kinase C in the human erythrocyte. Translocation to the plasma membrane and phosphorylation of bands 4.1 and 4.9 and other membrane proteins. Palfrey, H.C., Waseem, A. J. Biol. Chem. (1985) [Pubmed]
  14. Muscular dystrophy in girls with X;autosome translocations. Boyd, Y., Buckle, V., Holt, S., Munro, E., Hunter, D., Craig, I. J. Med. Genet. (1986) [Pubmed]
  15. Microscopic Kinetics of DNA Translocation through synthetic nanopores. Aksimentiev, A., Heng, J.B., Timp, G., Schulten, K. Biophys. J. (2004) [Pubmed]
  16. Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca(2+)-depleted human neutrophils. Dusi, S., Della Bianca, V., Grzeskowiak, M., Rossi, F. Biochem. J. (1993) [Pubmed]
  17. Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1). Daimon, M., Susa, S., Suzuki, K., Kato, T., Yamatani, K., Sasaki, H. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  18. Mammalian Sec61 is associated with Sec62 and Sec63. Meyer, H.A., Grau, H., Kraft, R., Kostka, S., Prehn, S., Kalies, K.U., Hartmann, E. J. Biol. Chem. (2000) [Pubmed]
  19. Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events. Rotrosen, D., Leto, T.L. J. Biol. Chem. (1990) [Pubmed]
  20. Sustained Activity of Calcium Release-activated Calcium Channels Requires Translocation of Mitochondria to the Plasma Membrane. Quintana, A., Schwarz, E.C., Schwindling, C., Lipp, P., Kaestner, L., Hoth, M. J. Biol. Chem. (2006) [Pubmed]
  21. In vivo Evidence for Radial Migration of Neurons by Long-Distance Somal Translocation in the Developing Ferret Visual Cortex. Borrell, V., Kaspar, B.K., Gage, F.H., Callaway, E.M. Cereb. Cortex (2006) [Pubmed]
  22. Structural Rearrangements at the Translocation Pore of the Human Glutamate Transporter, EAAT1. Leighton, B.H., Seal, R.P., Watts, S.D., Skyba, M.O., Amara, S.G. J. Biol. Chem. (2006) [Pubmed]
  23. Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation. Balsinde, J., Diez, E., Mollinedo, F. J. Biol. Chem. (1991) [Pubmed]
  24. The Translocation Inhibitor CAM741 Interferes with Vascular Cell Adhesion Molecule 1 Signal Peptide Insertion at the Translocon. Harant, H., Lettner, N., Hofer, L., Oberhauser, B., de Vries, J.E., Lindley, I.J. J. Biol. Chem. (2006) [Pubmed]
  25. Effects on Ligand Interaction and Membrane Translocation of the Positively Charged Arginine Residues Situated along the C1 Domain Binding Cleft in the Atypical Protein Kinase C Isoforms. Pu, Y., Peach, M.L., Garfield, S.H., Wincovitch, S., Marquez, V.E., Blumberg, P.M. J. Biol. Chem. (2006) [Pubmed]
  26. Homer 1 Mediates Store- and Inositol 1,4,5-Trisphosphate Receptor-dependent Translocation and Retrieval of TRPC3 to the Plasma Membrane. Kim, J.Y., Zeng, W., Kiselyov, K., Yuan, J.P., Dehoff, M.H., Mikoshiba, K., Worley, P.F., Muallem, S. J. Biol. Chem. (2006) [Pubmed]
  27. Structural Requirements of FGF-1 for Receptor Binding and Translocation into Cells. Zakrzewska, M., Krowarsch, D., Wiedlocha, A., Olsnes, S., Otlewski, J. Biochemistry (2006) [Pubmed]
  28. Tail-anchored and signal-anchored proteins utilize overlapping pathways during membrane insertion. Abell, B.M., Jung, M., Oliver, J.D., Knight, B.C., Tyedmers, J., Zimmermann, R., High, S. J. Biol. Chem. (2003) [Pubmed]
  29. The Calmodulin-binding Site of Sphingosine Kinase and Its Role in Agonist-dependent Translocation of Sphingosine Kinase 1 to the Plasma Membrane. Sutherland, C.M., Moretti, P.A., Hewitt, N.M., Bagley, C.J., Vadas, M.A., Pitson, S.M. J. Biol. Chem. (2006) [Pubmed]
  30. DNA topoisomerase II in therapy-related acute promyelocytic leukemia. Mistry, A.R., Felix, C.A., Whitmarsh, R.J., Mason, A., Reiter, A., Cassinat, B., Parry, A., Walz, C., Wiemels, J.L., Segal, M.R., Adès, L., Blair, I.A., Osheroff, N., Peniket, A.J., Lafage-Pochitaloff, M., Cross, N.C., Chomienne, C., Solomon, E., Fenaux, P., Grimwade, D. N. Engl. J. Med. (2005) [Pubmed]
  31. Association of rap1 and rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation. Maridonneau-Parini, I., de Gunzburg, J. J. Biol. Chem. (1992) [Pubmed]
  32. The Role of LMO2 in Development and in T Cell Leukemia After Chromosomal Translocation or Retroviral Insertion. Nam, C.H., Rabbitts, T.H. Mol. Ther. (2006) [Pubmed]
  33. Plasma endotoxin and cytokine concentrations in patients with hemorrhagic shock. Endo, S., Inada, K., Yamada, Y., Takakuwa, T., Kasai, T., Nakae, H., Yoshida, M., Ceska, M. Crit. Care Med. (1994) [Pubmed]
  34. Progressive Visual Loss in Subfoveal Exudation in Age-related Macular Degeneration: A Meta-analysis Using Lineweaver-Burke Plots. Shah, A.R., Del Priore, L.V. Am. J. Ophthalmol. (2007) [Pubmed]
  35. Prevalence of Bartonella infection in wild African lions (Panthera leo) and cheetahs (Acinonyx jubatus). Molia, S., Chomel, B.B., Kasten, R.W., Leutenegger, C.M., Steele, B.R., Marker, L., Martenson, J.S., Keet, D.F., Bengis, R.G., Peterson, R.P., Munson, L., O'Brien, S.J. Vet. Microbiol. (2004) [Pubmed]
  36. Radial shift of the ulnar fingers: a new technique for special cases of longitudinal central deficiency. Foucher, G., Loréa, P., Hovius, S., Pivato, G., Medina, J. Journal of hand surgery (Edinburgh, Lothian) (2006) [Pubmed]
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