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Gene Review

DDR2  -  discoidin domain receptor tyrosine kinase 2

Homo sapiens

Synonyms: CD167 antigen-like family member B, Discoidin domain receptor 2, Discoidin domain-containing receptor 2, Discoidin domain-containing receptor tyrosine kinase 2, MIG20a, ...
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Disease relevance of DDR2


High impact information on DDR2


Biological context of DDR2


Anatomical context of DDR2


Associations of DDR2 with chemical compounds


Regulatory relationships of DDR2


Other interactions of DDR2

  • Moreover, DDR2 overexpression increases SMC-mediated collagen and elastin degradation in vitro [11].
  • ColI treatment induced DDR2 phosphorylation and subsequently induced the upregulation of IL-12 production, CD86 expression, and antigen uptake activity by immature DCs [15].
  • CONCLUSIONS: DDR2, a TK that is stimulated by fibrillar collagens that accumulate in cirrhotic livers, is present at elevated levels in the small bile ducts of PBC patients [3].
  • The widely expressed mammalian discoidin domain receptors (DDRs), DDR1 and DDR2, are unique among receptor tyrosine kinases in that they are activated by the extracellular matrix protein collagen [17].
  • V-FGR, RET and DDR2 were also expressed [18].

Analytical, diagnostic and therapeutic context of DDR2


  1. An extracellular matrix-specific microarray allowed the identification of target genes downstream of discoidin domain receptors. Faraci, E., Eck, M., Gerstmayer, B., Bosio, A., Vogel, W.F. Matrix Biol. (2003) [Pubmed]
  2. Binding of discoidin domain receptor 2 to collagen I: an atomic force microscopy investigation. Agarwal, G., Kovac, L., Radziejewski, C., Samuelsson, S.J. Biochemistry (2002) [Pubmed]
  3. Elevated expression of tyrosine kinase DDR2 in primary biliary cirrhosis. Mao, T.K., Kimura, Y., Kenny, T.P., Branchi, A., Gishi, R.G., Van de Water, J., Kung, H.J., Friedman, S.L., Gershwin, M.E. Autoimmunity (2002) [Pubmed]
  4. Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. Wall, S.J., Werner, E., Werb, Z., DeClerck, Y.A. J. Biol. Chem. (2005) [Pubmed]
  5. The discoidin domain receptor tyrosine kinases are activated by collagen. Vogel, W., Gish, G.D., Alves, F., Pawson, T. Mol. Cell (1997) [Pubmed]
  6. A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1. Noordeen, N.A., Carafoli, F., Hohenester, E., Horton, M.A., Leitinger, B. J. Biol. Chem. (2006) [Pubmed]
  7. Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. Yang, K., Kim, J.H., Kim, H.J., Park, I.S., Kim, I.Y., Yang, B.S. J. Biol. Chem. (2005) [Pubmed]
  8. Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. Xu, L., Peng, H., Wu, D., Hu, K., Goldring, M.B., Olsen, B.R., Li, Y. J. Biol. Chem. (2005) [Pubmed]
  9. The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2. Leitinger, B., Steplewski, A., Fertala, A. J. Mol. Biol. (2004) [Pubmed]
  10. Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. Ikeda, K., Wang, L.H., Torres, R., Zhao, H., Olaso, E., Eng, F.J., Labrador, P., Klein, R., Lovett, D., Yancopoulos, G.D., Friedman, S.L., Lin, H.C. J. Biol. Chem. (2002) [Pubmed]
  11. Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Ferri, N., Carragher, N.O., Raines, E.W. Am. J. Pathol. (2004) [Pubmed]
  12. Functional analysis of discoidin domain receptor 2 in synovial fibroblasts in rheumatoid arthritis. Wang, J., Lü, H., Liu, X., Deng, Y., Sun, T., Li, F., Ji, S., Nie, X., Yao, L. J. Autoimmun. (2002) [Pubmed]
  13. The discoidin domain receptor DDR2 is a receptor for type X collagen. Leitinger, B., Kwan, A.P. Matrix Biol. (2006) [Pubmed]
  14. Exploring the collagen-binding site of the DDR1 tyrosine kinase receptor. Abdulhussein, R., McFadden, C., Fuentes-Prior, P., Vogel, W.F. J. Biol. Chem. (2004) [Pubmed]
  15. Discoidin domain receptor 2 is involved in the activation of bone marrow-derived dendritic cells caused by type I collagen. Lee, J.E., Kang, C.S., Guan, X.Y., Kim, B.T., Kim, S.H., Lee, Y.M., Moon, W.S., Kim, D.K. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  16. Regular expression of discoidin domain receptor 2 in the improved adjuvant-induced animal model for rheumatoid arthritis. Li, W., Zhang, Y.Q., Liu, X.P., Yao, L.B., Sun, L. Chin. Med. Sci. J. (2005) [Pubmed]
  17. Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. Identification of collagen binding sites in DDR2. Leitinger, B. J. Biol. Chem. (2003) [Pubmed]
  18. Cloning and sequencing of protein kinase cDNA from harbor seal (Phoca vitulina) lymphocytes. Neale, J.C., Kenny, T.P., Gershwin, M.E. Clin. Dev. Immunol. (2004) [Pubmed]
  19. Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea. Mohan, R.R., Mohan, R.R., Wilson, S.E. Exp. Eye Res. (2001) [Pubmed]
  20. Discoidin domain receptor 2 inhibits fibrillogenesis of collagen type 1. Mihai, C., Iscru, D.F., Druhan, L.J., Elton, T.S., Agarwal, G. J. Mol. Biol. (2006) [Pubmed]
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