Chemical Compound Review:
CNQX 7-nitro-2,3-dioxo-1,4- dihydroquinoxaline-6...
Synonyms:
Tocris-0190, AC1MWAKF, C127_SIGMA, SureCN1662279, SureCN2460241, ...
- 2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin. Rosenberg, P.A., Loring, R., Xie, Y., Zaleskas, V., Aizenman, E. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C. Mao, J., Price, D.D., Mayer, D.J. J. Neurosci. (1994)
- Up-regulation of glutamate receptors in nucleus tractus solitarii underlies potentiation of baroreceptor reflex by heat shock protein 70. Chan, S.H., Chang, K.F., Ou, C.C., Chan, J.Y. Mol. Pharmacol. (2002)
- Hypoxic cell death in human NT2-N neurons: involvement of NMDA and non-NMDA glutamate receptors. Rootwelt, T., Dunn, M., Yudkoff, M., Itoh, T., Almaas, R., Pleasure, D. J. Neurochem. (1998)
- Brain edema induced by in vitro ischemia: causal factors and neuroprotection. MacGregor, D.G., Avshalumov, M.V., Rice, M.E. J. Neurochem. (2003)
- Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Bäckström, P., Hyytiä, P. Neuropsychopharmacology (2006)
- Feeding induced by microinjections of NMDA and AMPA-kainate receptor antagonists into ventral striatal and ventral pallidal areas of the pigeon. Da Silva, A.A., Marino-Neto, J., Paschoalini, M.A. Brain Res. (2003)
- Inhibitory avoidance training induces rapid and selective changes in 3[H]AMPA receptor binding in the rat hippocampal formation. Cammarota, M., Izquierdo, I., Wolfman, C., Levi de Stein, M., Bernabeu, R., Jerusalinsky, D., Medina, J.H. Neurobiology of learning and memory. (1995)
- Effects of MK-801 and CNQX on various neurotoxic responses induced by kainic acid in mice. Lee, J.K., Choi, S.S., Lee, H.K., Han, K.J., Han, E.J., Suh, H.W. Mol. Cells (2002)
- Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Steward, O., Worley, P.F. Neuron (2001)
- Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Rodríguez-Moreno, A., Herreras, O., Lerma, J. Neuron (1997)
- Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors. Couratier, P., Hugon, J., Sindou, P., Vallat, J.M., Dumas, M. Lancet (1993)
- Selective glutamate receptor antagonists can induce or prevent axonal sprouting in rat hippocampal slice cultures. McKinney, R.A., Lüthi, A., Bandtlow, C.E., Gähwiler, B.H., Thompson, S.M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- A visceral pain pathway in the dorsal column of the spinal cord. Willis, W.D., Al-Chaer, E.D., Quast, M.J., Westlund, K.N. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. Michaels, R.L., Rothman, S.M. J. Neurosci. (1990)
- Myositis-induced functional reorganisation of the rat dorsal horn: effects of spinal superfusion with antagonists to neurokinin and glutamate receptors. Hoheisel, U., Sander, B., Mense, S. Pain (1997)
- Parenterally administered kainic acid induces a persistent hyperalgesia in the mouse and rat. Giovengo, S.L., Kitto, K.F., Kurtz, H.J., Velázquez, R.A., Larson, A.A. Pain (1999)
- Investigations of non-NMDA receptor-induced toxicity in serum-free antioxidant-rich primary cultures of murine cerebellar granule cells. Carroll, F.Y., Cheung, N.S., Beart, P.M. Neurochem. Int. (1998)
- A possible role of AA2 excitatory amino acid receptors in the expression of stimulant drug effects. Freed, W.J., Cannon-Spoor, H.E. Psychopharmacology (Berl.) (1990)
- Identification of a subunit-specific antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate/kainate receptor channels. Keller, B.U., Blaschke, M., Rivosecchi, R., Hollmann, M., Heinemann, S.F., Konnerth, A. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Hippocampal inputs to identified neurons in an in vitro slice preparation of the rat nucleus accumbens: evidence for feed-forward inhibition. Pennartz, C.M., Kitai, S.T. J. Neurosci. (1991)
- The effects of L-glutamate, AMPA, quisqualate, and kainate on retinal horizontal cells depend on adaptational state: implications for rod-cone interactions. Krizaj, D., Akopian, A., Witkovsky, P. J. Neurosci. (1994)
- Mechanism of acute ischemic injury of oligodendroglia in early myelinating white matter: the importance of astrocyte injury and glutamate release. Wilke, S., Thomas, R., Allcock, N., Fern, R. J. Neuropathol. Exp. Neurol. (2004)
- Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site. Lester, R.A., Quarum, M.L., Parker, J.D., Weber, E., Jahr, C.E. Mol. Pharmacol. (1989)
- Quantitative physiological characterization of a quinoxalinedione non-NMDA receptor antagonist. Yamada, K.A., Dubinsky, J.M., Rothman, S.M. J. Neurosci. (1989)
- Differential intracellular calcium responses to glutamate in type 1 and type 2 cultured brain astrocytes. Jensen, A.M., Chiu, S.Y. J. Neurosci. (1991)
- Prevention of normally occurring and deafferentation-induced neuronal death in chick brainstem auditory neurons by periodic blockade of AMPA/kainate receptors. Solum, D., Hughes, D., Major, M.S., Parks, T.N. J. Neurosci. (1997)
- The effects of intrathecal administration of excitatory amino acid agonists and antagonists on the initiation of locomotion in the adult cat. Douglas, J.R., Noga, B.R., Dai, X., Jordan, L.M. J. Neurosci. (1993)
- Arrest of afferent axon extension by target neurons in vitro is regulated by the NMDA receptor. Baird, D.H., Trenkner, E., Mason, C.A. J. Neurosci. (1996)
- Pre- and postsynaptic determinants of EPSC waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses. Takahashi, M., Kovalchuk, Y., Attwell, D. J. Neurosci. (1995)
- Enhanced activation of NMDA receptor responses at the immature retinogeniculate synapse. Ramoa, A.S., McCormick, D.A. J. Neurosci. (1994)
- Facilitatory coupling between a glutamate metabotropic receptor and dihydropyridine-sensitive calcium channels in cultured cerebellar granule cells. Chavis, P., Nooney, J.M., Bockaert, J., Fagni, L., Feltz, A., Bossu, J.L. J. Neurosci. (1995)
- Circadian phase shifts to neuropeptide Y In vitro: cellular communication and signal transduction. Biello, S.M., Golombek, D.A., Schak, K.M., Harrington, M.E. J. Neurosci. (1997)
- Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input. Akaoka, H., Aston-Jones, G. J. Neurosci. (1991)
- Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease. Xiong, H., McCabe, L., Costello, J., Anderson, E., Weber, G., Ikezu, T. Neurobiol. Aging (2004)
- Blockade of ionotropic glutamate receptors produces neuronal apoptosis through the Bax-cytochrome C-caspase pathway: the causative role of Ca2+ deficiency. Yoon, W.J., Won, S.J., Ryu, B.R., Gwag, B.J. J. Neurochem. (2003)
- Glutamate receptor binding in the human hippocampus and adjacent cortex during development and aging. Johnson, M., Perry, R.H., Piggott, M.A., Court, J.A., Spurden, D., Lloyd, S., Ince, P.G., Perry, E.K. Neurobiol. Aging (1996)
- Alterations in glutamate but not GABAA receptor subunit expression as a consequence of epileptiform activity in vitro. Gerfin-Moser, A., Grogg, F., Rietschin, L., Thompson, S.M., Streit, P. Neuroscience (1995)
- Glutamatergic excitatory responses of anterior cingulate neurons to stimulation of the mediodorsal thalamus and their regulation by GABA: an in vivo iontophoretic study. Gigg, J., Tan, A.M., Finch, D.M. Cereb. Cortex (1992)
- Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission. Lukatch, H.S., Kiddoo, C.E., Maciver, M.B. Cereb. Cortex (2005)
- Glutamatergic control of dopamine release during stress in the rat prefrontal cortex. Jedema, H.P., Moghaddam, B. J. Neurochem. (1994)
- Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord. Liaw, W.J., Stephens, R.L., Binns, B.C., Chu, Y., Sepkuty, J.P., Johns, R.A., Rothstein, J.D., Tao, Y.X. Pain (2005)
- Mature hippocampal astrocytes exhibit functional metabotropic and ionotropic glutamate receptors in situ. Shelton, M.K., McCarthy, K.D. Glia (1999)