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Gene Review

CXCL14  -  chemokine (C-X-C motif) ligand 14

Sus scrofa

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Disease relevance of CXCL14


High impact information on CXCL14


Biological context of CXCL14


Anatomical context of CXCL14

  • Immunohistologic studies showed that each agent also inhibited graft infiltration by NK and T cells, and expression of various cytokines, including the chemokine monocyte chemoattractant protein-1 (MCP-1), but did not affect the tempo or extent of MO infiltration [12].
  • Effects of leflunomide and deoxyspergualin in the guinea pig-->rat cardiac model of delayed xenograft rejection: suppression of B cell and C-C chemokine responses but not induction of macrophage lectin [12].
  • Epithelial cells are a major cellular source of the chemokine eotaxin in the guinea pig lung [13].
  • The gastrointestinal epithelium represents a barrier to potentially invasive enteric pathogens, maintains a role in innate immune surveillance, and is a source of both chemokine and cytokine chemotactic mediators in response to bacterial invasion [4].
  • Our data demonstrate that invasive bacterial pathogens in the pig gastrointestinal tract trigger upregulation of selected cytokine and chemokine mediators, but serovars of Salmonella elicited differing patterns of activation in vitro [4].

Other interactions of CXCL14


Analytical, diagnostic and therapeutic context of CXCL14

  • Quantitative real-time RT-PCR was used in this study to investigate the pulmonary expression profiles of cytokine and chemokine mRNA in response to single or repeated CS exposure in guinea pigs [16].


  1. Mouse Eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response. Ganzalo, J.A., Jia, G.Q., Aguirre, V., Friend, D., Coyle, A.J., Jenkins, N.A., Lin, G.S., Katz, H., Lichtman, A., Copeland, N., Kopf, M., Gutierrez-Ramos, J.C. Immunity (1996) [Pubmed]
  2. Glycosaminoglycan binding properties of the myxoma virus CC-chemokine inhibitor, M-T1. Seet, B.T., Barrett, J., Robichaud, J., Shilton, B., Singh, R., McFadden, G. J. Biol. Chem. (2001) [Pubmed]
  3. A macrophage inflammatory protein homolog encoded by guinea pig cytomegalovirus signals via CC chemokine receptor 1. Penfold, M., Miao, Z., Wang, Y., Haggerty, S., Schleiss, M.R. Virology (2003) [Pubmed]
  4. Effects of Salmonella enterica serovars Typhimurium (ST) and Choleraesuis (SC) on chemokine and cytokine expression in swine ileum and jejunal epithelial cells. Skjolaas, K.A., Burkey, T.E., Dritz, S.S., Minton, J.E. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  5. Propagermanium suppresses macrophage-mediated formation of coronary arteriosclerotic lesions in pigs in vivo. Shimokawa, H., Eto, Y., Miyata, K., Morishige, K., Kandabashi, T., Matsushima, K., Takeshita, A. J. Cardiovasc. Pharmacol. (2003) [Pubmed]
  6. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. Collins, P.D., Marleau, S., Griffiths-Johnson, D.A., Jose, P.J., Williams, T.J. J. Exp. Med. (1995) [Pubmed]
  7. Recombinant guinea pig CCL5 (RANTES) differentially modulates cytokine production in alveolar and peritoneal macrophages. Skwor, T.A., Cho, H., Cassidy, C., Yoshimura, T., McMurray, D.N. J. Leukoc. Biol. (2004) [Pubmed]
  8. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation. Zoja, C., Donadelli, R., Colleoni, S., Figliuzzi, M., Bonazzola, S., Morigi, M., Remuzzi, G. Kidney Int. (1998) [Pubmed]
  9. A novel porcine gammaherpesvirus. Chmielewicz, B., Goltz, M., Franz, T., Bauer, C., Brema, S., Ellerbrok, H., Beckmann, S., Rziha, H.J., Lahrmann, K.H., Romero, C., Ehlers, B. Virology (2003) [Pubmed]
  10. Post-transplant upregulation of chemokine messenger RNA in non-human primate recipients of intraportal pig islet xenografts. Hårdstedt, M., Finnegan, C.P., Kirchhof, N., Hyland, K.A., Wijkstrom, M., Murtaugh, M.P., Hering, B.J. Xenotransplantation (2005) [Pubmed]
  11. Murine chemokine gene expression in rejecting pig proislet xenografts. Paule, M.F., McColl, S.R., Simeonovic, C.J. Transplant. Proc. (2000) [Pubmed]
  12. Effects of leflunomide and deoxyspergualin in the guinea pig-->rat cardiac model of delayed xenograft rejection: suppression of B cell and C-C chemokine responses but not induction of macrophage lectin. Hancock, W.W., Miyatake, T., Koyamada, N., Kut, J.P., Soares, M., Russell, M.E., Bach, F.H., Sayegh, M.H. Transplantation (1997) [Pubmed]
  13. Epithelial cells are a major cellular source of the chemokine eotaxin in the guinea pig lung. Cook, E.B., Stahl, J.L., Lilly, C.M., Haley, K.J., Sanchez, H., Luster, A.D., Graziano, F.M., Rothenberg, M.E. Allergy and asthma proceedings : the official journal of regional and state allergy societies. (1998) [Pubmed]
  14. Effects of inhaled eotaxin on airway function and inflammatory cell influx in sensitised and non-sensitised guinea pigs. Smith, N., Johnson, F.J. Pulmonary pharmacology & therapeutics. (2006) [Pubmed]
  15. Interleukin (IL)-8 (CXCL8) induces cytokine expression and superoxide formation by guinea pig neutrophils infected with Mycobacterium tuberculosis. Lyons, M.J., Yoshimura, T., McMurray, D.N. Tuberculosis (Edinburgh, Scotland) (2004) [Pubmed]
  16. Cytokine and chemokine expression in cigarette smoke-induced lung injury in guinea pigs. Kubo, S., Kobayashi, M., Masunaga, Y., Ishii, H., Hirano, Y., Takahashi, K., Shimizu, Y. Eur. Respir. J. (2005) [Pubmed]
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