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Gene Review

CCL2  -  chemokine (C-C motif) ligand 2

Sus scrofa

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Disease relevance of MCP-1


High impact information on MCP-1


Biological context of MCP-1


Anatomical context of MCP-1

  • Human MCP-1 attracted 1% of input guinea pig peritoneal exudate macrophages at its highest concentration of 2.5 x 10(-8) M [6].
  • The bacterial cell wall was observed to be the major cytokine-inducting components, whereas capsule expression was important for MCP-1 activation [11].
  • Real-time PCR analysis revealed that pre-treatment of neutrophils induced elevated levels of IL-8 and TNF-alpha mRNA and protein as well as superoxide, but not mRNA for MCP-1, IFN-gamma, or TGF-beta when compared to neutrophils pre-stimulated with media alone [12].
  • We also defined, in vitro, whether bone marrow (BM) cells secrete vascular endothelial growth factor (VEGF) and macrophage chemoattractant protein-1 (MCP-1) [7].
  • Collateralization in a porcine hindlimb model served to provide a proof-of-principle for the functional benefit of MCP-1 overexpression [13].

Associations of MCP-1 with chemical compounds


Other interactions of MCP-1


Analytical, diagnostic and therapeutic context of MCP-1


  1. Molecular mechanisms of decreased steroid responsiveness induced by latent adenoviral infection in allergic lung inflammation. Yamada, K., Elliott, W.M., Brattsand, R., Valeur, A., Hogg, J.C., Hayashi, S. J. Allergy Clin. Immunol. (2002) [Pubmed]
  2. Expression of monocyte chemoattractant protein-1 but not interleukin-8 in granulomatous lesions in lymph nodes from pigs with naturally occurring postweaning multisystemic wasting syndrome. Kim, J., Chae, C. Vet. Pathol. (2003) [Pubmed]
  3. Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death. Skrabal, C.A., Thompson, L.O., Potapov, E.V., Southard, R.E., Joyce, D.L., Youker, K.A., Noon, G.P., Loebe, M. J. Surg. Res. (2005) [Pubmed]
  4. Propagermanium suppresses macrophage-mediated formation of coronary arteriosclerotic lesions in pigs in vivo. Shimokawa, H., Eto, Y., Miyata, K., Morishige, K., Kandabashi, T., Matsushima, K., Takeshita, A. J. Cardiovasc. Pharmacol. (2003) [Pubmed]
  5. Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Sekine, O., Nishio, Y., Egawa, K., Nakamura, T., Maegawa, H., Kashiwagi, A. J. Biol. Chem. (2002) [Pubmed]
  6. cDNA cloning of guinea pig monocyte chemoattractant protein-1 and expression of the recombinant protein. Yoshimura, T. J. Immunol. (1993) [Pubmed]
  7. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. Fuchs, S., Baffour, R., Zhou, Y.F., Shou, M., Pierre, A., Tio, F.O., Weissman, N.J., Leon, M.B., Epstein, S.E., Kornowski, R. J. Am. Coll. Cardiol. (2001) [Pubmed]
  8. HMG-CoA reductase inhibitors reduce vascular monocyte chemotactic protein-1 expression in early lesions from hypercholesterolemic swine independently of their effect on plasma cholesterol levels. Martínez-González, J., Alfón, J., Berrozpe, M., Badimon, L. Atherosclerosis (2001) [Pubmed]
  9. In vivo human MCP-1 transfection in porcine arteries by intravascular electroporation. Seidler, R.W., Allgäuer, S., Ailinger, S., Sterner, A., Dev, N., Rabussay, D., Doods, H., Lenter, M.C. Pharm. Res. (2005) [Pubmed]
  10. Porcine luteal cells express monocyte chemoattractant protein-1 (MCP-1): analysis by polymerase chain reaction and cDNA cloning. Hosang, K., Knoke, I., Klaudiny, J., Wempe, F., Wuttke, W., Scheit, K.H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  11. Proinflammatory cytokine and chemokine modulation by Streptococcus suis in a whole-blood culture system. Segura, M., Vanier, G., Al-Numani, D., Lacouture, S., Olivier, M., Gottschalk, M. FEMS Immunol. Med. Microbiol. (2006) [Pubmed]
  12. Interleukin (IL)-8 (CXCL8) induces cytokine expression and superoxide formation by guinea pig neutrophils infected with Mycobacterium tuberculosis. Lyons, M.J., Yoshimura, T., McMurray, D.N. Tuberculosis (Edinburgh, Scotland) (2004) [Pubmed]
  13. Nonviral monocyte chemoattractant protein-1 gene transfer improves arteriogenesis after femoral artery occlusion. Muhs, A., Lenter, M.C., Seidler, R.W., Zweigerdt, R., Kirchengast, M., Weser, R., Ruediger, M., Guth, B. Gene Ther. (2004) [Pubmed]
  14. Monocyte chemoattractant protein-1 and its receptor CCR-2 in piglet lungs exposed to inhaled nitric oxide and hyperoxia. Ekekezie, I.I., Thibeault, D.W., Garola, R.E., Truog, W.E. Pediatr. Res. (2001) [Pubmed]
  15. Smooth muscle cells influence monocyte response to LDL as well as their adhesion and transmigration in a coculture model of the arterial wall. Kinard, F., Jaworski, K., Sergent-Engelen, T., Goldstein, D., Van Veldhoven, P.P., Holvoet, P., Trouet, A., Schneider, Y.J., Remacle, C. J. Vasc. Res. (2001) [Pubmed]
  16. Red wine inhibits monocyte chemotactic protein-1 expression and modestly reduces neointimal hyperplasia after balloon injury in cholesterol-Fed rabbits. Feng, A.N., Chen, Y.L., Chen, Y.T., Ding, Y.Z., Lin, S.J. Circulation (1999) [Pubmed]
  17. Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine. Schierack, P., Nordhoff, M., Pollmann, M., Weyrauch, K.D., Amasheh, S., Lodemann, U., Jores, J., Tachu, B., Kleta, S., Blikslager, A., Tedin, K., Wieler, L.H. Histochem. Cell Biol. (2006) [Pubmed]
  18. C-reactive protein correlates with macrophage accumulation in coronary arteries of hypercholesterolemic pigs. Turk, J.R., Carroll, J.A., Laughlin, M.H., Thomas, T.R., Casati, J., Bowles, D.K., Sturek, M. J. Appl. Physiol. (2003) [Pubmed]
  19. Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1. Voskuil, M., van Royen, N., Hoefer, I.E., Seidler, R., Guth, B.D., Bode, C., Schaper, W., Piek, J.J., Buschmann, I.R. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
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