Disease relevance of MINK1

• Preincubation of B55 MAb (a murine immunoglobulin M MAb directed against a human milk fat globulin), the control antibody, with LPS from E. coli 0111:B4 decreased the mean peak TxB2 but had no effect on the other parameters [1].
• We demonstrated an increased frequency of B63 in patients with HPV types other than HPV 16 or 18, and B55 in patients that were negative for all HPV types [2].
• The sensitivity of a target panel including Burkitt lymphoma (BL) lines suggested that the peptide presented by the B55 molecule differs in A and B type EBV strain carrying cells [3].
• Toxoplasmosis in a Free-ranging Mink [4].
• Eight Mink (Mustela vison) were inoculated orally with Aujeszky's disease virus (ADV) [5].

Psychiatry related information on MINK1

• Properly characterizing clusters of families who have children with mental retardation: a comment on Mink, Blacher, and Nihira [6].

High impact information on MINK1

• Taken together, these results suggest that hMINK beta plays an important role in cytoskeleton reorganization, cell adhesion, and cell motility [7].
• Finally, hMINK beta protein was found to colocalize with the Golgi apparatus, implicating that hMINK beta might exert its functions, at least in part, through the modulation of intracellular protein transport [7].
• Taken together these data show that, in mammalian fibroblasts, the intermediate filament protein vimentin is dephosphorylated by PP2A, an event targeted by B55 [8].
• Furthermore, vimentin-associated PP2A catalytic subunit was displaced in B55-depleted cells [8].
• Specific depletion of B55 in living cells by antisense B55 RNA was accompanied by disassembly and increased phosphorylation of vimentin, as when type 2A phosphatases were inhibited using okadaic acid [8].

Chemical compound and disease context of MINK1

• Cell membrane proteins of avian sarcoma virus B77V--transformed cells LWF B55 and LWF B77 and uninfected rat embryo fibroblasts were analyzed by SDS acrylamide gel electrophoresis [9].

Biological context of MINK1

• Gene expression and yeast two-hybrid analysis of yeast homologs of the MINK-1 domains suggest that MINK-1 may be involved in cell-cycle progression and cytoskeletal control [10].
• AIM: Mink protein, a beta-subunit of I(ks) potassium channels modulate cardiac cellular electrophysiology, and experimental data demonstrated that NO is involved in cardiac vagal activity and in the inhibition of sympathetic activity [11].
• A nonsignificant association was also found with HLA B55 that is in linkage disequilibrium with DRB1*0407 [12].
• The segregation of the apo B55 allele was confirmed in the family using the 3' variable number of tandem repeats of the apo B gene.(ABSTRACT TRUNCATED AT 250 WORDS)[13]
• On the other hand, the sequence of exons 3 to 7 was identical to those of some B15 and B46 alleles, suggesting that B*5603 was generated by a recombination event between one of the B55 and B56 alleles and one of the B15 and B46 alleles in intron 2 [14].

Anatomical context of MINK1

• In mammalian fibroblasts, B55 protein was distributed ubiquitously throughout the cytoplasm with a fraction associated to vimentin [8].
• The culture contained HLA-A1, A11 and B55 restricted, LCL selective cytotoxic T cells (CTLs) [3].
• Pertinent laboratory data were: serum (s)-Fe 148 microg/dl; unsaturated iron binding capacity (UIBC) 14 microg/dl; s-ferritin 9350 ng/ml; human leukocyte antigen (HLA) A2, A24, B39, B55, Cw1, Cw7 [15].
• The lymphocytes of one HLA-A11 positive individual (A1, A11, B49, B55) were stimulated in vitro with the autologous EBV transformed lymphoblastoid cell line (LCL) [3].
• The first report on stapedius reflex and general anaesthesia was published by Mink et al. in 1981 [16].

Associations of MINK1 with chemical compounds

• Mercury and Mink. II. Experimental methyl mercury intoxication [17].

Other interactions of MINK1

• Consistent with these predicted functions, our in-house yeast two-hybrid screen for proteins that interact with human MINK-1 provides strong evidence that the coiled-coil and proline-rich domains of MINK-1 participate in the regulation of cytoskeletal organization, cell-cycle control and apoptosis [10].

Analytical, diagnostic and therapeutic context of MINK1

• Both biochemical fractionation and immunofluorescence analysis of detergent-extracted cells revealed that fractions of PP2Ac, PR65, and B55 were tightly associated with vimentin [8].
• When transfected into RSV-infected cells, this minigenome was "rescued," as evidenced by high levels of CAT expression and the production of transmissible particles which propagated and expressed high levels of CAT expression during serial passage (P.L. Collins, M. A. Mink, and D. S. Stec, Proc. Natl. Acad. Sci. USA, 88:9663-9667, 1991) [18].
• Hybridization to Northern blots of total leaf RNA revealed that both RPr 82/9 and RPr 84/82 were indistinguishable from the parental line (Maris Mink), having normal amounts of a 5.7-kb mRNA species [19].
• Patients with HLA B55, B62 and CW3 had a significantly lower viral load, and showed a better response to interferon [20].
• Sequence alignment of these A subunit binding domains (ASBD) identified conserved residues in B/B55 and PR72 family members [21].

References