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Gene Review

MNG1  -  multinodular goitre 1

Homo sapiens

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Disease relevance of MNG1


Psychiatry related information on MNG1


High impact information on MNG1


Chemical compound and disease context of MNG1


Biological context of MNG1


Anatomical context of MNG1


Associations of MNG1 with chemical compounds


Other interactions of MNG1


Analytical, diagnostic and therapeutic context of MNG1


  1. Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer. Bignell, G.R., Canzian, F., Shayeghi, M., Stark, M., Shugart, Y.Y., Biggs, P., Mangion, J., Hamoudi, R., Rosenblatt, J., Buu, P., Sun, S., Stoffer, S.S., Goldgar, D.E., Romeo, G., Houlston, R.S., Narod, S.A., Stratton, M.R., Foulkes, W.D. Am. J. Hum. Genet. (1997) [Pubmed]
  2. Hyperthyroidism and thyroid cancer. Edmonds, C.J., Tellez, M. Clin. Endocrinol. (Oxf) (1988) [Pubmed]
  3. Changes in stimulating and blocking TSH receptor antibodies in a patient undergoing three cycles of transition from hypo to hyper-thyroidism and back to hypothyroidism. Kraiem, Z., Baron, E., Kahana, L., Sadeh, O., Sheinfeld, M. Clin. Endocrinol. (Oxf) (1992) [Pubmed]
  4. Characterization of TSH antagonist activity in the serum of patients with thyroid disease. Hashim, F.A., Creagh, F.M., Hawrani, A.E., Parkes, A.B., Buckland, P.R., Rees Smith, B. Clin. Endocrinol. (Oxf) (1986) [Pubmed]
  5. Thyroid stimulating hormone receptor antibody levels in Singaporean patients with autoimmune thyroid disease. Khoo, D.H., Fok, A.C., Tan, C.E., Koh, L.K., Lim, S.C., Eng, P.H., Ho, S.C. Ann. Acad. Med. Singap. (1997) [Pubmed]
  6. An unusual case of the Capgras syndrome. Fialkov, M.J., Robins, A.H. The British journal of psychiatry : the journal of mental science. (1978) [Pubmed]
  7. Place of radioactive iodine in treatment of thyrotoxicosis. Hennemann, G., Krenning, E.P., Sankaranarayanan, K. Lancet (1986) [Pubmed]
  8. Demonstration of a circulating autoantibody against a soluble eye-muscle antigen in Graves' ophthalmopathy. Kodama, K., Sikorska, H., Bandy-Dafoe, P., Bayly, R., Wall, J.R. Lancet (1982) [Pubmed]
  9. Thyroid-stimulating immunoglobulins do not cause non-autonomous, autonomous, or toxic multinodular goitres. Bolk, J.H., Elte, J.W., Bussemaker, J.K., Haak, A., van der Heide, D. Lancet (1979) [Pubmed]
  10. Do thyroid-stimulating immunoglobulins cause non-toxic and toxic multinodular goitre? Brown, R.S., Jackson, I.M., Pohl, S.L., Reichlin, S. Lancet (1978) [Pubmed]
  11. E-cadherin: a differentiation marker in thyroid malignancies. Brabant, G., Hoang-Vu, C., Cetin, Y., Dralle, H., Scheumann, G., Mölne, J., Hansson, G., Jansson, S., Ericson, L.E., Nilsson, M. Cancer Res. (1993) [Pubmed]
  12. Haematopoietic growth factor in antithyroid-drug-induced agranulocytosis. Andrès, E., Kurtz, J.E., Perrin, A.E., Dufour, P., Schlienger, J.L., Maloisel, F. QJM : monthly journal of the Association of Physicians. (2001) [Pubmed]
  13. Bone metabolism during anti-thyroid drug treatment of endogenous subclinical hyperthyroidism. Mudde, A.H., Houben, A.J., Nieuwenhuijzen Kruseman, A.C. Clin. Endocrinol. (Oxf) (1994) [Pubmed]
  14. The sodium-iodide symporter protein is always present at a low expression and confined to the cell membrane in nonfunctioning nonadenomatous nodules of toxic nodular goitre. Tonacchera, M., Viacava, P., Fanelli, G., Agretti, P., De Marco, G., De Servi, M., Di Cosmo, C., Chiovato, L., Pinchera, A., Vitti, P. Clin. Endocrinol. (Oxf) (2004) [Pubmed]
  15. Galectin-3 does not reliably distinguish benign from malignant thyroid neoplasms. Mehrotra, P., Okpokam, A., Bouhaidar, R., Johnson, S.J., Wilson, J.A., Davies, B.R., Lennard, T.W. Histopathology (2004) [Pubmed]
  16. Lithium associated thyrotoxicosis: a report of 14 cases, with statistical analysis of incidence. Barclay, M.L., Brownlie, B.E., Turner, J.G., Wells, J.E. Clin. Endocrinol. (Oxf) (1994) [Pubmed]
  17. Genetic heterogeneity in familial nonmedullary thyroid carcinoma: exclusion of linkage to RET, MNG1, and TCO in 56 families. NMTC Consortium. Lesueur, F., Stark, M., Tocco, T., Ayadi, H., Delisle, M.J., Goldgar, D.E., Schlumberger, M., Romeo, G., Canzian, F. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  18. A comprehensive analysis of MNG1, TCO1, fPTC, PTEN, TSHR, and TRKA in familial nonmedullary thyroid cancer: confirmation of linkage to TCO1. Bevan, S., Pal, T., Greenberg, C.R., Green, H., Wixey, J., Bignell, G., Narod, S.A., Foulkes, W.D., Stratton, M.R., Houlston, R.S. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  19. Development of a luminescent bioassay for thyroid stimulating antibodies. Evans, C., Morgenthaler, N.G., Lee, S., Llewellyn, D.H., Clifton-Bligh, R., John, R., Lazarus, J.H., Chatterjee, V.K., Ludgate, M. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  20. Analysis of apoptosis in relation to tissue destruction associated with Hashimoto's autoimmune thyroiditis. Hammond, L.J., Lowdell, M.W., Cerrano, P.G., Goode, A.W., Bottazzo, G.F., Mirakian, R. J. Pathol. (1997) [Pubmed]
  21. Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1). International Consortium for the Genetics of Autoimmune Thyroid Disease. Tomer, Y., Barbesino, G., Greenberg, D.A., Concepcion, E., Davies, T.F. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  22. At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family. McKay, J.D., Williamson, J., Lesueur, F., Stark, M., Duffield, A., Canzian, F., Romeo, G., Hoffman, L. Eur. J. Endocrinol. (1999) [Pubmed]
  23. Multinodular goitre with giant cell vasculitis of thyroid arteries in a woman with temporal arteritis. Granel, B., Serratrice, J., Chaudier, B., Rey, J., Swiader, L., Pache, X., Christides, C., Disdier, P., Weiller, P.J., De Micco, C., Henry, J.F. Ann. Rheum. Dis. (2001) [Pubmed]
  24. The gamma delta T cell repertoire in Graves' disease and multinodular goitre. McIntosh, R.S., Tandon, N., Pickerill, A.P., Davies, R., Barnett, D., Weetman, A.P. Clin. Exp. Immunol. (1993) [Pubmed]
  25. No restriction of intrathyroidal T cell receptor V alpha families in the thyroid of Graves' disease. McIntosh, R.S., Watson, P.F., Pickerill, A.P., Davies, R., Weetman, A.P. Clin. Exp. Immunol. (1993) [Pubmed]
  26. Prevalence of sporadic medullary thyroid carcinoma: the importance of routine measurement of serum calcitonin in the diagnostic evaluation of thyroid nodules. Rieu, M., Lame, M.C., Richard, A., Lissak, B., Sambort, B., Vuong-Ngoc, P., Berrod, J.L., Fombeur, J.P. Clin. Endocrinol. (Oxf) (1995) [Pubmed]
  27. Toxic multinodular goitre in a patient with generalized resistance to thyroid hormone who harbours the R429Q mutation in the thyroid hormone receptor beta gene. Taniyama, M., Ishikawa, N., Momotani, N., Ito, K., Ban, Y. Clin. Endocrinol. (Oxf) (2001) [Pubmed]
  28. Association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and TSH-suppressed nodular goitre patients. Yavuz, D.G., Yüksel, M., Deyneli, O., Ozen, Y., Aydin, H., Akalin, S. Clin. Endocrinol. (Oxf) (2004) [Pubmed]
  29. Is humoral thyroid autoimmunity relevant in amiodarone iodine-induced thyrotoxicosis (AIIT)? Martino, E., Macchia, E., Aghini-Lombardi, F., Antonelli, A., Lenziardi, M., Concetti, R., Fenzi, G.F., Baschieri, L., Pinchera, A. Clin. Endocrinol. (Oxf) (1986) [Pubmed]
  30. Propranolol improves the impaired TSH response to TRH in patients with autonomously functioning euthyroid multinodular goitre. Elte, J.W., Haak, A., Wiarda, K.S., Frölich, M., van der Velde, E.A., van der Heide, D., Querido, A. Clin. Endocrinol. (Oxf) (1982) [Pubmed]
  31. Further indications for genetic heterogeneity of euthyroid familial goiter. Neumann, S., Bayer, Y., Reske, A., Tajtáková, M., Langer, P., Paschke, R. J. Mol. Med. (2003) [Pubmed]
  32. Assays of TSH-receptor antibodies in 576 patients with various thyroid disorders: their incidence, significance and clinical usefulness. Macchia, E., Concetti, R., Borgoni, F., Cetani, F., Fenzi, G.F., Pinchera, A. Autoimmunity (1989) [Pubmed]
  33. Effect of glucocorticoids and oestrogen on interleukin-6 production by human thyrocytes from patients with Graves' disease and toxic multinodular goitre and from HTori3 cells. Jones, T.H., Kennedy, R.L., Justice, S.K., Davies, R. Eur. J. Endocrinol. (1997) [Pubmed]
  34. Induction of stimulating thyrotropin receptor antibodies after radioiodine therapy for toxic multinodular goitre and Graves' disease measured with a novel bioassay. Hovens, G.C., Heemstra, K.A., Buiting, A.M., Stokkel, M.P., Karperien, M., Ballieux, B.E., Pereira, A.M., Romijn, J.A., Smit, J.W. Nuclear medicine communications (2007) [Pubmed]
  35. An update on thyroid surgery. Gimm, O., Brauckhoff, M., Thanh, P.N., Sekulla, C., Dralle, H. Eur. J. Nucl. Med. Mol. Imaging (2002) [Pubmed]
  36. Comparison between preoperative cytology and intraoperative frozen-section biopsy in the diagnosis of thyroid nodules. Rodríguez, J.M., Parrilla, P., Sola, J., Bas, A., Aguilar, J., Moreno, A., Soria, T. The British journal of surgery. (1994) [Pubmed]
  37. Characterization of neural cell adhesion molecule (NCAM) expression in thyroid follicular cells: induction by cytokines and over-expression in autoimmune glands. Vargas, F., Tolosa, E., Sospedra, M., Catálfamo, M., Lucas-Martín, A., Obiols, G., Pujol-Borrell, R. Clin. Exp. Immunol. (1994) [Pubmed]
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