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Gene Review

Tslp  -  thymic stromal lymphopoietin

Mus musculus

Synonyms: Thymic stroma-derived lymphopoietin, Thymic stromal lymphopoietin
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Disease relevance of Tslp


High impact information on Tslp

  • These Lin(-)CD45R(lo-neg)CD19(+) cells responded to thymic stromal lymphopoietin and 'preferentially' reconstituted functional sIgM(hi)CD11b(+)CD5(lo-neg) B-1 B cells, but not sIgM(+)CD11b(-) B-2 B cells, in vivo [5].
  • Lung-specific expression of a Tslp transgene induced airway inflammation and hyperreactivity characterized by T helper type 2 cytokines and increased immunoglobulin E [6].
  • In addition, TSLP exerts an effect indirectly through DCs to promote Th2 differentiation of CD4+ T cells [7].
  • Thymic stromal lymphopoietin (TSLP) is a cytokine that promotes CD4+ T cell homeostasis [7].
  • The cytokine thymic stromal lymphopoietin (TSLP) has recently been implicated in the pathogenesis of atopic dermatitis (AD) and other allergic diseases in humans [3].

Chemical compound and disease context of Tslp


Biological context of Tslp

  • The gene encoding TSLP was mapped to murine chromosome 18 [10].
  • The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library [11].
  • B-cell development, including the IgM+ compartment, was unaffected by loss of the TSLP pathway, as were T lymphopoiesis and lymphocyte proliferation in vitro [12].
  • TSLP induced phosphorylation of signal transducer and activator of transcription (STAT)-5 [13].
  • Finally, we demonstrate that thymic stromal lymphopoietin, whose expression is rapidly and strongly induced in RXRalphabeta-ablated keratinocytes, plays a key role in initiating the skin and systemic AD-like pathologies [9].

Anatomical context of Tslp


Associations of Tslp with chemical compounds

  • IL-7 has been studied extensively, but only recently has it become possible to unravel the role of TSLP in detail [14].
  • Furthermore, topical application of retinoic acid receptor RARgamma-selective agonist BMS961 also induces TSLP expression either on its own or synergistically with 1alpha,25-(OH)(2)D(3) [8].

Other interactions of Tslp


Analytical, diagnostic and therapeutic context of Tslp


  1. A role for thymic stromal lymphopoietin in CD4(+) T cell development. Al-Shami, A., Spolski, R., Kelly, J., Fry, T., Schwartzberg, P.L., Pandey, A., Mackall, C.L., Leonard, W.J. J. Exp. Med. (2004) [Pubmed]
  2. Cryoglobulinemic glomerulonephritis in thymic stromal lymphopoietin transgenic mice. Taneda, S., Segerer, S., Hudkins, K.L., Cui, Y., Wen, M., Segerer, M., Wener, M.H., Khairallah, C.G., Farr, A.G., Alpers, C.E. Am. J. Pathol. (2001) [Pubmed]
  3. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. Yoo, J., Omori, M., Gyarmati, D., Zhou, B., Aye, T., Brewer, A., Comeau, M.R., Campbell, D.J., Ziegler, S.F. J. Exp. Med. (2005) [Pubmed]
  4. Deletion of the fcgamma receptor IIb in thymic stromal lymphopoietin transgenic mice aggravates membranoproliferative glomerulonephritis. Mühlfeld, A.S., Segerer, S., Hudkins, K., Carling, M.D., Wen, M., Farr, A.G., Ravetch, J.V., Alpers, C.E. Am. J. Pathol. (2003) [Pubmed]
  5. Identification of a B-1 B cell-specified progenitor. Montecino-Rodriguez, E., Leathers, H., Dorshkind, K. Nat. Immunol. (2006) [Pubmed]
  6. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Zhou, B., Comeau, M.R., De Smedt, T., Liggitt, H.D., Dahl, M.E., Lewis, D.B., Gyarmati, D., Aye, T., Campbell, D.J., Ziegler, S.F. Nat. Immunol. (2005) [Pubmed]
  7. A role for TSLP in the development of inflammation in an asthma model. Al-Shami, A., Spolski, R., Kelly, J., Keane-Myers, A., Leonard, W.J. J. Exp. Med. (2005) [Pubmed]
  8. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Li, M., Hener, P., Zhang, Z., Kato, S., Metzger, D., Chambon, P. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Li, M., Messaddeq, N., Teletin, M., Pasquali, J.L., Metzger, D., Chambon, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Molecular cloning and biological characterization of a novel murine lymphoid growth factor. Sims, J.E., Williams, D.E., Morrissey, P.J., Garka, K., Foxworthe, D., Price, V., Friend, S.L., Farr, A., Bedell, M.A., Jenkins, N.A., Copeland, N.G., Grabstein, K., Paxton, R.J. J. Exp. Med. (2000) [Pubmed]
  11. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. Park, L.S., Martin, U., Garka, K., Gliniak, B., Di Santo, J.P., Muller, W., Largaespada, D.A., Copeland, N.G., Jenkins, N.A., Farr, A.G., Ziegler, S.F., Morrissey, P.J., Paxton, R., Sims, J.E. J. Exp. Med. (2000) [Pubmed]
  12. Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development. Carpino, N., Thierfelder, W.E., Chang, M.S., Saris, C., Turner, S.J., Ziegler, S.F., Ihle, J.N. Mol. Cell. Biol. (2004) [Pubmed]
  13. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Quentmeier, H., Drexler, H.G., Fleckenstein, D., Zaborski, M., Armstrong, A., Sims, J.E., Lyman, S.D. Leukemia (2001) [Pubmed]
  14. Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment. Vosshenrich, C.A., Cumano, A., Müller, W., Di Santo, J.P., Vieira, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  15. Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Lee, H.C., Ziegler, S.F. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  16. Cytokine functions in the formative stages of a lymphocyte's life. Kang, J., Der, S.D. Curr. Opin. Immunol. (2004) [Pubmed]
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