Disease relevance of CNTN5

• Comparative study of serum human growth hormone measurement with NB2 lymphoma cell bioassay, IM-9 receptor modulation assay, and radioimmunoassay in children with disorders of growth [1].
• NB-2 and NB-64 inhibited HIV-1 fusion and entry by interfering with the gp41 six-helix bundle formation and disrupting the alpha-helical conformation [2].
• Transfusion-related acute lung injury caused by an NB2 granulocyte-specific antibody in a patient with thrombotic thrombocytopenic purpura [3].
• 2 (NB2), Mueller-Hinton broth (MH), brucella broth (BB), brain heat infusion broth supplemented with 0.6% (w/v) yeast extract (BHIYE), tryptone soya broth supplemented with 0.6% (w/v) yeast extract (TSBYE) and Campylobacter broth (KAMPY) employing a spectrophotometrical growth assay model [4].
• BS RNase 50 microg/ml was proven to induce 49.7, 54 and 68.1% apoptosis in the cells of the ML-2 myeloid cell line and two neuroblastoma cell lines: NB-1 and NB-2, respectively [5].

High impact information on CNTN5

• These results suggest that NB-2 and NB-64 may bind to the gp41 hydrophobic pocket through hydrophobic and ionic interactions and block the formation of the fusion-active gp41 core, thereby inhibiting HIV-1-mediated membrane fusion and virus entry [2].
• The human NB-2 gene (CNTN5) was mapped to chromosome 11q21-q22.2 by fluorescence in situ hybridization [6].
• Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members [6].
• The long isoform of human NB-2 consists of 1100 amino acids residues that are 91% homologous to rat NB-2 at the amino acid sequence level [6].
• Among various regions of the adult human brain, high-level expression of NB-2 was detected in the amygdala and occipital lobe, whereas expression was low in the corpus callosum, caudate nucleus, and spinal cord [6].

Biological context of CNTN5

• This NA null phenotype was converted to the normal phenotype of NA1, NB2 by the transplantation of bone marrow from an HLA-identical sibling [7].
• A PCR-based microsatellite analysis of 1p confirmed the loss of heterozygosity, including NB1 and NB2 putative tumor-suppressor gene regions [8].
• Some preparations of hGH were highly potent in the NA 71 immunoassay, but not in the NB2, cell-proliferation assay, suggesting the presence of antigenically active but biologically inactive hormone [9].
• CAPD and hemodialysis patients were matched also by hematocrit, serum creatinine, albumin concentrations and duration and dialysis (0-79 months), the prolactin levels in serum and in effluent were measured by RIA and NB2 bioassay [10].

Anatomical context of CNTN5

• Alloantibodies specific for neutrophil antigens NA1, NA2, NB2, 5b, and 9a did not react with neutrophil cytoplasmic components [11].
• Serologic studies demonstrated that the serum from the second RBC donor had no HLA antibodies but did have a granulocyte-specific antibody (anti-NB2) that caused the agglutination of the recipient's granulocytes, which were NB2 positive [3].
• The topographic relationship of epitopes to the biologically active regions on the hormone was examined on the basis of the neutralizing potency of MABs in the proliferation of the prolactin-dependent cell line NB2 [12].

Associations of CNTN5 with chemical compounds

• Human alloantibodies have been used to identify the 58- to 64-kDa glycoprotein (GP) on which NB1 antigen is located, but an NB2 antigen-bearing molecule has not yet been identified [13].

Other interactions of CNTN5

• NB-2 is one of the neural recognition molecules in the contactin subgroup, which belongs to the immunoglobulin superfamily [6].

Analytical, diagnostic and therapeutic context of CNTN5

• We tested alloantibodies specific for neutrophil antigens NA1, NA2, NB1, NB2, 5b, 9a, and Mart in an ANCA-indirect immunofluorescence (ANCA-IF) assay to determine if these alloantibodies reacted with neutrophil cytoplasmic or granule antigens [11].
• Bioassays (pigeon crop sac assays and NB2 cell assays) were carried out in two laboratories, radioreceptor assays by one laboratory and radioimmunoassays by 17 laboratories [14].
• PURPOSE: The aim of this study was to compare the retention and stability of the Nobel Biocare standard ball (NBS), Nobel Biocare 2.25-mm-diameter ball (NB2), Zest Anchor (ZA), Zest Anchor Advanced Generation (ZAAG), Sterngold ERA orange (SEO), and Sterngold ERA white (SEW) attachments on an implant-retained overdenture model [15].
• Cell cultures were stimulated by a N. brasiliensis crude cytoplasmic antigen (NB) and five semi-purified protein fractions (NB2, NB4, NB6, NB8, and NB10) separated by isoelectric [16].

References