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Gene Review

CNTN1  -  contactin 1

Homo sapiens

Synonyms: Contactin-1, F3, GP135, Glycoprotein gp135, MYPCN, ...
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Disease relevance of CNTN1


High impact information on CNTN1


Chemical compound and disease context of CNTN1


Biological context of CNTN1

  • Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12 [8].
  • These animals (TAG/F3 mice) display a developmentally regulated cerebellar phenotype in which the size of the cerebellum is markedly reduced during the first two postnatal weeks but subsequently recovers [9].
  • Antibodies to the cell adhesion molecule F3/contactin of the Ig superfamily blocked the BD- but not the D6-dependent effect [10].
  • The alternatively spliced BD cassettes are prominently expressed in the developing hippocampus, as shown by reverse transcription PCR, and colocalize with F3 expression during perinatal periods when axon growth and the establishment of hippocampal connections take place [10].
  • Many of them, including the drosophila fasciclin 1 as well as the mammalian glycoproteins Thy-1, TAG1, N-CAM and F11,F3, contactin are members of the immunoglobulin gene superfamily [11].

Anatomical context of CNTN1

  • These data are consistent with a model in which deployment of F3/contactin on granule cells affects proliferation and differentiation of these neurons as well as the differentiation of their synaptic partners, the Purkinje cells [9].
  • We showed previously that a recombinant Fc fusion protein with the C domain (beta C) binds to contactin and supports neuronal adhesion and neurite growth [12].
  • Contactin-1 was differentially expressed in tumor tissues, and its expression correlated with tumor stage, lymph node metastasis, and patient survival [1].
  • Suppression of contactin-1 expression abolished the ability of lung adenocarcinoma cells to invade Matrigel in vitro as well as the polymerization of filamentous-actin and the formation of focal adhesion structures [1].
  • In contrast, normal astrocytes did not express contactin [2].

Associations of CNTN1 with chemical compounds

  • Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta [12].
  • Through affinity chromatography of membrane glycoproteins from chick brain on tenascin-Sepharose, we isolated a major cell surface ligand of 135 kD which we identified as contactin/F11 by NH2-terminal sequencing [13].
  • Regulated expression of the cell adhesion glycoprotein F3 in adult hypothalamic magnocellular neurons [14].
  • Confocal and electron microscopy localized F3 in secretory granules in all neuronal compartments, a localization confirmed by detection of F3 immunoreactivity in granule-enriched fractions obtained by sucrose density gradient fractionation of rat neurohypophyses [14].
  • In the present study, we report the isolation of two fractions of F3-containing microdomains from adult cerebellum on the basis of their resistance to solubilization by Triton X-100 at 4 degrees C. Both fractions were composed of vesicles, ranging from 100 to 200 nm in diameter [15].

Physical interactions of CNTN1


Other interactions of CNTN1


Analytical, diagnostic and therapeutic context of CNTN1


  1. Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. Su, J.L., Yang, C.Y., Shih, J.Y., Wei, L.H., Hsieh, C.Y., Jeng, Y.M., Wang, M.Y., Yang, P.C., Kuo, M.L. Cancer Res. (2006) [Pubmed]
  2. Contactin is expressed in human astrocytic gliomas and mediates repulsive effects. Eckerich, C., Zapf, S., Ulbricht, U., Müller, S., Fillbrandt, R., Westphal, M., Lamszus, K. Glia (2006) [Pubmed]
  3. F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Hu, Q.D., Ang, B.T., Karsak, M., Hu, W.P., Cui, X.Y., Duka, T., Takeda, Y., Chia, W., Sankar, N., Ng, Y.K., Ling, E.A., Maciag, T., Small, D., Trifonova, R., Kopan, R., Okano, H., Nakafuku, M., Chiba, S., Hirai, H., Aster, J.C., Schachner, M., Pallen, C.J., Watanabe, K., Xiao, Z.C. Cell (2003) [Pubmed]
  4. Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization. Nie, D.Y., Zhou, Z.H., Ang, B.T., Teng, F.Y., Xu, G., Xiang, T., Wang, C.Y., Zeng, L., Takeda, Y., Xu, T.L., Ng, Y.K., Faivre-Sarrailh, C., Popko, B., Ling, E.A., Schachner, M., Watanabe, K., Pallen, C.J., Tang, B.L., Xiao, Z.C. EMBO J. (2003) [Pubmed]
  5. The glycosylphosphatidyl inositol-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/contactin-associated protein (caspr). Faivre-Sarrailh, C., Gauthier, F., Denisenko-Nehrbass, N., Le Bivic, A., Rougon, G., Girault, J.A. J. Cell Biol. (2000) [Pubmed]
  6. Protein tyrosine phosphatase alpha (PTPalpha) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn. Zeng, L., D'Alessandri, L., Kalousek, M.B., Vaughan, L., Pallen, C.J. J. Cell Biol. (1999) [Pubmed]
  7. Sequence similarity between the envelope surface unit (SU) glycoproteins of primate and small ruminant lentiviruses. Hötzel, I., Cheevers, W.P. Virus Res. (2000) [Pubmed]
  8. Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12. Berglund, E.O., Ranscht, B. Genomics (1994) [Pubmed]
  9. Transgenic mice expressing F3/contactin from the TAG-1 promoter exhibit developmentally regulated changes in the differentiation of cerebellar neurons. Bizzoca, A., Virgintino, D., Lorusso, L., Buttiglione, M., Yoshida, L., Polizzi, A., Tattoli, M., Cagiano, R., Rossi, F., Kozlov, S., Furley, A., Gennarini, G. Development (2003) [Pubmed]
  10. Tenascin-C promotes neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule F3/contactin. Rigato, F., Garwood, J., Calco, V., Heck, N., Faivre-Sarrailh, C., Faissner, A. J. Neurosci. (2002) [Pubmed]
  11. Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system. Walsh, F.S., Doherty, P. Cell Biol. Int. Rep. (1991) [Pubmed]
  12. Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta. Sakurai, T., Lustig, M., Nativ, M., Hemperly, J.J., Schlessinger, J., Peles, E., Grumet, M. J. Cell Biol. (1997) [Pubmed]
  13. Neuronal cell adhesion molecule contactin/F11 binds to tenascin via its immunoglobulin-like domains. Zisch, A.H., D'Alessandri, L., Ranscht, B., Falchetto, R., Winterhalter, K.H., Vaughan, L. J. Cell Biol. (1992) [Pubmed]
  14. Regulated expression of the cell adhesion glycoprotein F3 in adult hypothalamic magnocellular neurons. Pierre, K., Rougon, G., Allard, M., Bonhomme, R., Gennarini, G., Poulain, D.A., Theodosis, D.T. J. Neurosci. (1998) [Pubmed]
  15. The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum. Olive, S., Dubois, C., Schachner, M., Rougon, G. J. Neurochem. (1995) [Pubmed]
  16. Competition and cooperation between tenascin-R, lecticans and contactin 1 regulate neurite growth and morphology. Zacharias, U., Rauch, U. J. Cell. Sci. (2006) [Pubmed]
  17. Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. Kamei, Y., Takeda, Y., Teramoto, K., Tsutsumi, O., Taketani, Y., Watanabe, K. Genomics (2000) [Pubmed]
  18. Molecular alterations underlie nodal and paranodal degeneration in type 1 diabetic neuropathy and are prevented by C-peptide. Sima, A.A., Zhang, W., Li, Z.G., Murakawa, Y., Pierson, C.R. Diabetes (2004) [Pubmed]
  19. Caspr regulates the processing of contactin and inhibits its binding to neurofascin. Gollan, L., Salomon, D., Salzer, J.L., Peles, E. J. Cell Biol. (2003) [Pubmed]
  20. Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent. Pierre, K., Dupouy, B., Allard, M., Poulain, D.A., Theodosis, D.T. Eur. J. Neurosci. (2001) [Pubmed]
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