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Gene Review

Mcpt2  -  mast cell protease 2

Rattus norvegicus

Synonyms: Group-specific protease, Mast cell protease 2, Mast cell protease II, rMCP-2, rMCP-II
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Disease relevance of Mcpt2


High impact information on Mcpt2


Biological context of Mcpt2


Anatomical context of Mcpt2


Associations of Mcpt2 with chemical compounds


Other interactions of Mcpt2


Analytical, diagnostic and therapeutic context of Mcpt2


  1. Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum. Scudamore, C.L., Thornton, E.M., McMillan, L., Newlands, G.F., Miller, H.R. J. Exp. Med. (1995) [Pubmed]
  2. Macrophage engulfment of mucosal mast cells in rats treated with dexamethasone. Soda, K., Kawabori, S., Perdue, M.H., Bienenstock, J. Gastroenterology (1991) [Pubmed]
  3. Mercuric chloride-induced vasculitis in the Brown Norway rat: alpha beta T cell-dependent and -independent phases: role of the mast cell. Kiely, P.D., Pecht, I., Oliveira, D.B. J. Immunol. (1997) [Pubmed]
  4. Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions. Dimitriadou, V., Rouleau, A., Trung Tuong, M.D., Newlands, G.J., Miller, H.R., Luffau, G., Schwartz, J.C., Garbarg, M. Neuroscience (1997) [Pubmed]
  5. The effect of protein deficiency on systemic release of rat mucosal mast cell protease II during Nippostrongylus brasiliensis infection and following systemic anaphylaxis. Cummins, A.G., Kenny, A.L., Duncombe, V.M., Bolin, T.D., Davis, A.E. Immunol. Cell Biol. (1987) [Pubmed]
  6. Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II. MacQueen, G., Marshall, J., Perdue, M., Siegel, S., Bienenstock, J. Science (1989) [Pubmed]
  7. A human antibody binds to alpha-galactose receptors and mimics the effects of Clostridium difficile toxin A in rat colon. Pothoulakis, C., Galili, U., Castagliuolo, I., Kelly, C.P., Nikulasson, S., Dudeja, P.K., Brasitus, T.A., LaMont, J.T. Gastroenterology (1996) [Pubmed]
  8. Nitric oxide inhibits rat intestinal secretion by Clostridium difficile toxin A but not Vibrio cholerae enterotoxin. Qiu, B., Pothoulakis, C., Castagliuolo, I., Nikulasson, Z., LaMont, J.T. Gastroenterology (1996) [Pubmed]
  9. Ketotifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum. Pothoulakis, C., Karmeli, F., Kelly, C.P., Eliakim, R., Joshi, M.A., O'Keane, C.J., Castagliuolo, I., LaMont, J.T., Rachmilewitz, D. Gastroenterology (1993) [Pubmed]
  10. Ion transport abnormalities in inflamed rat jejunum. Involvement of mast cells and nerves. Perdue, M.H., Marshall, J., Masson, S. Gastroenterology (1990) [Pubmed]
  11. Basal secretion and anaphylactic release of rat mast cell protease-II (RMCP-II) from ex vivo perfused rat jejunum: translocation of RMCP-II into the gut lumen and its relation to mucosal histology. Scudamore, C.L., Pennington, A.M., Thornton, E., McMillan, L., Newlands, G.F., Miller, H.R. Gut (1995) [Pubmed]
  12. Chronic allergy to dietary ovalbumin induces lymphocyte migration to rat small intestinal mucosa that is inhibited by MAdCAM-1. Ogawa, T., Miura, S., Tsuzuki, Y., Ogino, T., Teramoto, K., Inamura, T., Watanabe, C., Hokari, R., Nagata, H., Ishii, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  13. Modulation of rat uterine contractility by mast cells and their mediators. Garfield, R.E., Bytautiene, E., Vedernikov, Y.P., Marshall, J.S., Romero, R. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  14. Mast cell protease release and mucosal ultrastructure during intestinal anaphylaxis in the rat. Patrick, M.K., Dunn, I.J., Buret, A., Miller, H.R., Huntley, J.F., Gibson, S., Gall, D.G. Gastroenterology (1988) [Pubmed]
  15. The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. Hof, P., Mayr, I., Huber, R., Korzus, E., Potempa, J., Travis, J., Powers, J.C., Bode, W. EMBO J. (1996) [Pubmed]
  16. Induction of systemic immunologic tolerance to beta-lactoglobulin by oral administration of a whey protein hydrolysate. Fritsché, R., Pahud, J.J., Pecquet, S., Pfeifer, A. J. Allergy Clin. Immunol. (1997) [Pubmed]
  17. Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases. Ide, H., Itoh, H., Tomita, M., Murakumo, Y., Kobayashi, T., Maruyama, H., Osada, Y., Nawa, Y. Biochem. J. (1995) [Pubmed]
  18. Quercetin-induced expression of rat mast cell protease II and accumulation of secretory granules in rat basophilic leukemia cells. Trnovsky, J., Letourneau, R., Haggag, E., Boucher, W., Theoharides, T.C. Biochem. Pharmacol. (1993) [Pubmed]
  19. Nonatopic allergen-independent mast cell activation in parasitized eosinophilic athymic rats. Stoten, A., Huntley, J., Mistry, H., Harper, S., Bundick, R., Brown, A., Pritchard, D.I. Parasite Immunol. (2005) [Pubmed]
  20. Expression of mast cell proteases in rat lung during helminth infection: mast cells express both rat mast cell protease II and tryptase in helminth infected lung. Tomita, M., Itoh, H., Kobayashi, T., Onitsuka, T., Nawa, Y. Int. Arch. Allergy Immunol. (1999) [Pubmed]
  21. Amino acid sequence of rat mast cell protease I (chymase). Le Trong, H., Parmelee, D.C., Walsh, K.A., Neurath, H., Woodbury, R.G. Biochemistry (1987) [Pubmed]
  22. A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats. Castagliuolo, I., Leeman, S.E., Bartolak-Suki, E., Nikulasson, S., Qiu, B., Carraway, R.E., Pothoulakis, C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  23. Dietary wheat germ agglutinin modulates ovalbumin-induced immune responses in Brown Norway rats. Watzl, B., Neudecker, C., Hänsch, G.M., Rechkemmer, G., Pool-Zobel, B.L. Br. J. Nutr. (2001) [Pubmed]
  24. Concomitant detection of mucosal mast cells and eosinophils in the intestines of normal and Nippostrongylus-immune rats. A re-evaluation of histochemical and immunocytochemical techniques. Newlands, G.F., Huntley, J.F., Miller, H.R. Histochemistry (1984) [Pubmed]
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