Disease relevance of Il1f5

• Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells [1].
• Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines [2].
• Through its ability to induce glial differentiation and IL-1 release, GMF may represent an important endogenous signal, triggering both reactive gliosis and the development of an immune response within the central nervous system [3].
• Stimulatory effect on bone resorption of interleukin-1-like cytokine produced by an osteoblast-rich population of mouse calvarial cells [4].
• Interleukin 1-like factor produced by a hybrid of an adherent mouse spleen cell and a thymoma cell [5].

High impact information on Il1f5

• By the cothymocyte proliferation assay, it could be shown that mesangial cell supernatant induced splenic macrophage production of interleukin-1-like activity [6].
• Without lipopolysaccharide stimulation, only PEC from ADM-treated mice elaborated factor(s) with interleukin 1-like activity [7].
• Interleukin 1-like activity of peritoneal exudate cell supernatants isolated from mice on FOD was reduced [8].
• Recently we have demonstrated that epidermal cells (EC) perform monocyte/macrophage-like functions through the release of an interleukin 1-like immunomodulating mediator (EC-derived thymocyte activating factor; ETAF [9].
• Neither parathyroid hormone-like nor interleukin 1-like activity was present in the CM [10].

Biological context of Il1f5

• These results indicate that corneal epithelial cells, similar to keratinocytes, produce an Interleukin 1-like activity lacking species specificity, which enhances the proliferative capacity of thymocytes [11].
• Occurrence of interleukin-1-like immunoreactivity was demonstrated in the noradrenergic chromaffin cells of the rat and mouse adrenal gland by means of two antisera raised against synthetic peptides corresponding to the amino acid sequences 169-194 and 201-215 of the murine interleukin-1 precursor protein [12].
• Secretion and role of interleukin-1-like factor in the antibody response to dinitrophenyl dextran and other type 2 T-independent antigens [13].
• This report concerns specific binding sites for muramyl peptide in preparations of brain tissue, interaction between muramyl peptide and serotonin in binding to glial-derived cells, and the ability of both muramyl peptide and serotonin to induce release of interleukin-1-like activity from these cells [14].

Anatomical context of Il1f5

• Endotoxin-associated protein: interleukin-1-like activity on serum amyloid A synthesis and T-lymphocyte activation [15].
• GMF was also effective in triggering IL-1 release by macrophages [3].
• The effect of non-steroidal anti-inflammatory drugs on the accumulation and release of interleukin-1-like activity by peritoneal macrophages from the mouse [16].
• Spontaneous production of interleukin-1-like cytokine from a mouse osteoblastic cell line (MC3T3-E1) [17].
• Interleukin-1-like activity in human cerebrospinal fluid [18].

Associations of Il1f5 with chemical compounds

• Lidocaine-induced inhibition of the production of interleukin 1-like epidermal cell-derived thymocyte activating factor [19].
• Reduction of serum Interleukin-1-like activity after treatment with dexamethasone [20].
• By contrast, culture supernatants from macrophages incubated with urate crystals contained bone resorbing activity, which was only partly removed by dialysis, and interleukin 1 like activity [21].
• Culture supernatants from macrophages incubated with hydroxyapatite crystals contained dialysable bone resorbing activity, high concentrations of prostaglandin E2, but no interleukin 1 like activity [21].
• A factor with interleukin-1-like activity is produced by peritoneal cells from the frog, Xenopus laevis [22].

Other interactions of Il1f5

• The structure IL-1F5 lacks features that confer antagonist properties on IL-1Ra, and we predict that like IL-1beta it will act as an agonist [23].
• Induction of ornithine decarboxylase in the liver and spleen of mice by interleukin 1-like factors produced from a macrophage cell line [24].

Analytical, diagnostic and therapeutic context of Il1f5

• Involvement of interleukin-1-like factor(s) in type II collagen-induced arthritis in mice [25].
• Gel filtration analysis indicated that the interleukin-1-like cytokine exhibits some heterogeneity in size [17].

References