Gene Review:
Gcgr - glucagon receptor
Rattus norvegicus
Synonyms:
GL-R, Glucagon receptor
Unson,
Wu,
Jiang,
Yoo,
Cheung,
Sakmar,
Merrifield,
Szpirer,
Szpirer,
Vanvooren,
Rivière,
Maget,
Svoboda,
Shiozawa,
Simon,
Jacob,
Koike,
Morales,
Lachuer,
Duchamp,
Vera,
Georges,
Cohen-Adad,
Moulin,
Barré,
Sloop,
Cao,
Siesky,
Zhang,
Bodenmiller,
Cox,
Jacobs,
Moyers,
Owens,
Showalter,
Brenner,
Raap,
Gromada,
Berridge,
Monteith,
Porksen,
McKay,
Monia,
Bhanot,
Watts,
Michael,
- Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci. Szpirer, C., Szpirer, J., Vanvooren, P., Rivière, M., Maget, B., Svoboda, M., Shiozawa, M., Simon, J.S., Jacob, H.J., Koike, G. Mamm. Genome (1997)
- Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist. Johnson, D.G., Goebel, C.U., Hruby, V.J., Bregman, M.D., Trivedi, D. Science (1982)
- Characteristics of the interaction of the glucagon receptor, cAMP, and insulin secretion in parent cells and clone 5F of a cultured rat insulinoma. Korman, L.Y., Bhathena, S.J., Voyles, N.R., Oie, H.K., Recant, L. Diabetes (1985)
- Tissue-specific modulation of rat glucagon receptor mRNA by thyroid status. Morales, A., Lachuer, J., Duchamp, C., Vera, N., Georges, B., Cohen-Adad, F., Moulin, C., Barré, H. Mol. Cell. Endocrinol. (1998)
- Expression cloning and signaling properties of the rat glucagon receptor. Jelinek, L.J., Lok, S., Rosenberg, G.B., Smith, R.A., Grant, F.J., Biggs, S., Bensch, P.A., Kuijper, J.L., Sheppard, P.O., Sprecher, C.A. Science (1993)
- Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors. Sloop, K.W., Cao, J.X., Siesky, A.M., Zhang, H.Y., Bodenmiller, D.M., Cox, A.L., Jacobs, S.J., Moyers, J.S., Owens, R.A., Showalter, A.D., Brenner, M.B., Raap, A., Gromada, J., Berridge, B.R., Monteith, D.K., Porksen, N., McKay, R.A., Monia, B.P., Bhanot, S., Watts, L.M., Michael, M.D. J. Clin. Invest. (2004)
- Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus. Dighe, R.R., Rojas, F.J., Birnbaumer, L., Garber, A.J. J. Clin. Invest. (1984)
- Identification of a glucose response element in the promoter of the rat glucagon receptor gene. Portois, L., Maget, B., Tastenoy, M., Perret, J., Svoboda, M. J. Biol. Chem. (1999)
- Sequencing of eleven introns in genomic DNA encoding rat glucagon receptor and multiple alternative splicing of its mRNA. Maget, B., Tastenoy, M., Svoboda, M. FEBS Lett. (1994)
- Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise. Charbonneau, A., Melancon, A., Lavoie, C., Lavoie, J.M. Am. J. Physiol. Endocrinol. Metab. (2005)
- Glucagon receptor of human liver. Studies of its molecular weight and binding properties, and its ability to activate hepatic adenylyl cyclase of non-obese and obese subjects. Livingston, J.N., Einarsson, K., Backman, L., Ewerth, S., Arner, P. J. Clin. Invest. (1985)
- Regulatory effect of glucagon on its own receptor concentrations and target-cell sensitivity in the rat. Santos, A., Blazquez, E. Diabetologia (1982)
- Functional analysis of the glucose response element of the rat glucagon receptor gene in insulin-producing INS-1 cells. Portois, L., Tastenoy, M., Viollet, B., Svoboda, M. Biochim. Biophys. Acta (2002)
- Glucagon receptor-mediated extracellular signal-regulated kinase 1/2 phosphorylation in rat mesangial cells: role of protein kinase A and phospholipase C. Li, X.C., Carretero, O.A., Shao, Y., Zhuo, J.L. Hypertension (2006)
- Guanine nucleotide regulation of the interconversion of the two-state hepatic glucagon receptor system of rat. Wyborski, R.J., Horwitz, E.M., Jenkins, W.T., Mormol, J.S., Gurd, R.S. Arch. Biochem. Biophys. (1988)
- Coupling of the glucagon receptor to adenylyl cyclase by GDP: evidence for two levels of regulation of adenylyl cyclase. Iyengar, R., Birnbaumer, L. Proc. Natl. Acad. Sci. U.S.A. (1979)
- Glucagon receptors: effect of exercise and fasting. Lavoie, C. Canadian journal of applied physiology = Revue canadienne de physiologie appliquée. (2005)
- Two cytoplasmic loops of the glucagon receptor are required to elevate cAMP or intracellular calcium. Cypess, A.M., Unson, C.G., Wu, C.R., Sakmar, T.P. J. Biol. Chem. (1999)
- Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding. Unson, C.G., Cypess, A.M., Wu, C.R., Goldsmith, P.K., Merrifield, R.B., Sakmar, T.P. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Coupling of glucagon receptor to adenylyl cyclase. Requirement of a receptor-related guanyl nucleotide binding site for coupling of receptor to the enzyme. Iyengar, R., Swartz, T.L., Birnbaumer, L. J. Biol. Chem. (1979)
- Cross-talk between angiotensin II and glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangial cells. Li, X.C., Carretero, O.A., Zhuo, J.L. Biochem. Pharmacol. (2006)
- Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling. Unson, C.G., Wu, C.R., Jiang, Y., Yoo, B., Cheung, C., Sakmar, T.P., Merrifield, R.B. Biochemistry (2002)
- Mutational analysis of the glucagon receptor: similarities with the vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide (PACAP)/secretin receptors for recognition of the ligand's third residue. Perret, J., Van Craenenbroeck, M., Langer, I., Vertongen, P., Gregoire, F., Robberecht, P., Waelbroeck, M. Biochem. J. (2002)
- Effect of pinealectomy on liver insulin and glucagon receptor concentrations in the rat. Rodríguez, V., Mellado, C., Alvarez, E., De Diego, J.G., Blázquez, E. J. Pineal Res. (1989)
- Ligand-mediated internalization of glucagon receptors in intact rat liver. Authier, F., Desbuquois, B., De Galle, B. Endocrinology (1992)
- Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver. Diehl, A.M., Yang, S.Q., Cote, P., Wand, G.S. Hepatology (1992)
- Characterization of the glucagon receptor and its functional domains using monoclonal antibodies. Iwanij, V., Vincent, A.C. J. Biol. Chem. (1990)