The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

RARRES1  -  retinoic acid receptor responder...

Homo sapiens

Synonyms: LXNL, PEIG1, PERG-1, Phorbol ester-induced gene 1 protein, RAR-responsive protein TIG1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RARRES1


High impact information on RARRES1

  • The in vitro invasiveness (migration through extracellular matrix) and in vivo tumorigenicity (growth in nude mice) were assessed for the highly malignant PC-3M cell line transfected with TIG1 or control cDNA [5].
  • CONCLUSION: TIG1 may be a tumor suppressor gene whose diminished expression is involved in the malignant progression of prostate cancer [5].
  • Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity [5].
  • Is TIG1 a new tumor suppressor in prostate cancer [6]?
  • Although the expression and function of these introduced genetic elements were essentially the same, among four HDF, TIG-1 and TIG-3 were resistant to transformation [7].

Chemical compound and disease context of RARRES1


Biological context of RARRES1


Anatomical context of RARRES1


Associations of RARRES1 with chemical compounds

  • Treatment with demethylating agent 5-aza-2'-deoxycytidine restored both CRBP1 and TIG1 transcription [9].
  • We also show that TIG1 is upregulated by retinoic acid receptor but not by retinoid X receptor-specific synthetic retinoids [4].
  • Finally, we demonstrate that TIG1 is induced by AGN 190168 in psoriatic lesions during the course of clinical treatment of the disease [4].
  • TIG1 expression was also inducible by treatment with 1 micro M all-trans-retinoic acid for 3 days except in densely methylated cell lines [12].
  • Because TIG1 has been proposed to act as a tumor suppressor, we tested the hypothesis that cytosine methylation of the TIG1 promoter suppresses its expression and causes a loss of responsiveness to retinoic acid in some neoplastic cells [12].

Regulatory relationships of RARRES1

  • Four clones of SV40-transformed TIG-1 expressed cyclin D1 at moderate levels during their extended proliferative lifespan [13].

Other interactions of RARRES1

  • This study investigated the clinical significance of RARRES1 protein and its association with RARRES3 protein expression in 161 (26 adenoma, 13 distal normal mucosa and 122 primary colorectal adenocarcinoma) paraffin-embedded colorectal tissues by immunohistochemistry [2].
  • Using methylated CpG amplification-representation difference analysis, we identified a DNA fragment corresponding to the Tazarotene-induced gene 1 (TIG1) promoter-associated CpG island as one of the genes hypermethylated in the leukemia cell line K562 [12].
  • Combined GG1a, TIG1, and isolated hematuria at the time of biopsy enhanced the sensitivity to determine early IgA nephropathy and to define a nonearly cohort with a higher risk of disease progression appropriate for recruitment into clinical therapeutic trials within realistic time frames [14].

Analytical, diagnostic and therapeutic context of RARRES1


  1. DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. Mizuiri, H., Yoshida, K., Toge, T., Oue, N., Aung, P.P., Noguchi, T., Yasui, W. Cancer Sci. (2005) [Pubmed]
  2. RARRES1 expression is significantly related to tumour differentiation and staging in colorectal adenocarcinoma. Wu, C.C., Shyu, R.Y., Chou, J.M., Jao, S.W., Chao, P.C., Kang, J.C., Wu, S.T., Huang, S.L., Jiang, S.Y. Eur. J. Cancer (2006) [Pubmed]
  3. Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene. Zhang, J., Liu, L., Pfeifer, G.P. Oncogene (2004) [Pubmed]
  4. Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin. Nagpal, S., Patel, S., Asano, A.T., Johnson, A.T., Duvic, M., Chandraratna, R.A. J. Invest. Dermatol. (1996) [Pubmed]
  5. Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. Jing, C., El-Ghany, M.A., Beesley, C., Foster, C.S., Rudland, P.S., Smith, P., Ke, Y. J. Natl. Cancer Inst. (2002) [Pubmed]
  6. Is TIG1 a new tumor suppressor in prostate cancer? Lotan, R. J. Natl. Cancer Inst. (2002) [Pubmed]
  7. Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation. Akagi, T., Sasai, K., Hanafusa, H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Discovery of epigenetically masked tumor suppressor genes in endometrial cancer. Takai, N., Kawamata, N., Walsh, C.S., Gery, S., Desmond, J.C., Whittaker, S., Said, J.W., Popoviciu, L.M., Jones, P.A., Miyakawa, I., Koeffler, H.P. Mol. Cancer Res. (2005) [Pubmed]
  9. DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation. Shutoh, M., Oue, N., Aung, P.P., Noguchi, T., Kuraoka, K., Nakayama, H., Kawahara, K., Yasui, W. Cancer (2005) [Pubmed]
  10. Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma. Kwong, J., Lo, K.W., Chow, L.S., Chan, F.L., To, K.F., Huang, D.P. Int. J. Cancer (2005) [Pubmed]
  11. Ovocalyxin-32, a novel chicken eggshell matrix protein. isolation, amino acid sequencing, cloning, and immunocytochemical localization. Gautron, J., Hincke, M.T., Mann, K., Panheleux, M., Bain, M., McKee, M.D., Solomon, S.E., Nys, Y. J. Biol. Chem. (2001) [Pubmed]
  12. Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers. Youssef, E.M., Chen, X.Q., Higuchi, E., Kondo, Y., Garcia-Manero, G., Lotan, R., Issa, J.P. Cancer Res. (2004) [Pubmed]
  13. Enhanced expression of cyclin D1 in senescent human fibroblasts. Fukami, J., Anno, K., Ueda, K., Takahashi, T., Ide, T. Mech. Ageing Dev. (1995) [Pubmed]
  14. Primary IgA nephropathy with low histologic grade and disease progression: is there a "point of no return"? Lai, F.M., Szeto, C.C., Choi, P.C., Li, P.K., Tang, N.L., Chow, K.M., Lui, S.F., Wong, T.Y., Ho, K.K., To, K.F. Am. J. Kidney Dis. (2002) [Pubmed]
WikiGenes - Universities