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Gene Review

Nr5a2  -  nuclear receptor subfamily 5, group A,...

Rattus norvegicus

Synonyms: FTZ-F1 beta, Ftf, LRH-1, Liver receptor homolog 1, Lrh-1, ...
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High impact information on Nr5a2


Biological context of Nr5a2


Anatomical context of Nr5a2

  • Stage-specific expression of LRH-1 in rat granulosa and luteal cells suggests a role for LRH-1 in the regulation of ovarian function [5].
  • In the consecutive ovarian sections, expression of LRH-1 was approximately colocalized with that of P450arom in both tertiary and Graafian follicles and the functional CLs of pregnant rats [5].
  • Liver receptor homologue 1 (LRH-1) is a member of the nuclear receptor superfamily originally found in liver cells [5].
  • The colocalization of LRH-1 and aromatase to multiple testis cell types suggests that LRH-1 may have important effects on estrogen production, testis development, spermatogenesis, and testicular carcinogenesis [4].

Associations of Nr5a2 with chemical compounds

  • LRH-1 participates in regulation of cholesterol metabolism and bile acid synthesis [5].
  • SF-1 and FTF/LRH-1 were differentially regulated in vivo by estradiol, FSH and prolactin [6].
  • However, combination of FSH stimulation and Ad-LRH-1 infection led to significantly greater progesterone production and increases in mRNA for p450 side-chain cleavage and 3beta-hydroxysteroid dehydrogenase than granulosa cells stimulated by FSH alone [3].
  • In addition, the orphan nuclear receptor LRH-1 (liver receptor homologue-1) potentiated the sterol-dependent regulation of the sPLA(2) promoter by binding to an identified promoter element (TCAAGGCTG) [7].

Other interactions of Nr5a2

  • Recent studies have shown that LRH-1 is even more highly expressed in the ovary, and LRH-1 has been implicated as a key transcriptional regulator of cytochrome P450 aromatase (P450arom) in vitro [5].

Analytical, diagnostic and therapeutic context of Nr5a2

  • Using quantitative PCR our results show that FTF/LRH-1 message is expressed at higher levels in the ovary than in liver or other tissues analyzed [6].
  • Mutation analysis showed that induction by LRH-1 in TM3 and TM4 cells requires an AGGTCA motif at position -90, to which LRH-1 bound in gel shift analysis [4].


  1. The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Galarneau, L., Paré, J.F., Allard, D., Hamel, D., Levesque, L., Tugwood, J.D., Green, S., Bélanger, L. Mol. Cell. Biol. (1996) [Pubmed]
  2. Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. Schoonjans, K., Annicotte, J.S., Huby, T., Botrugno, O.A., Fayard, E., Ueda, Y., Chapman, J., Auwerx, J. EMBO Rep. (2002) [Pubmed]
  3. Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation. Saxena, D., Safi, R., Little-Ihrig, L., Zeleznik, A.J. Endocrinology (2004) [Pubmed]
  4. Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression. Pezzi, V., Sirianni, R., Chimento, A., Maggiolini, M., Bourguiba, S., Delalande, C., Carreau, S., Andò, S., Simpson, E.R., Clyne, C.D. Endocrinology (2004) [Pubmed]
  5. Expression and functional analysis of liver receptor homologue 1 as a potential steroidogenic factor in rat ovary. Liu, D.L., Liu, W.Z., Li, Q.L., Wang, H.M., Qian, D., Treuter, E., Zhu, C. Biol. Reprod. (2003) [Pubmed]
  6. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. Falender, A.E., Lanz, R., Malenfant, D., Belanger, L., Richards, J.S. Endocrinology (2003) [Pubmed]
  7. Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. Antonio, V., Janvier, B., Brouillet, A., Andreani, M., Raymondjean, M. Biochem. J. (2003) [Pubmed]
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