Gene Review:
Nr5a1 - nuclear receptor subfamily 5, group A,...
Mus musculus
Synonyms:
Ad4BP, Adrenal 4-binding protein, ELP, ELP-3, Embryonal LTR-binding protein, ...
- Cell-specific knockout of steroidogenic factor 1 reveals its essential roles in gonadal function. Jeyasuria, P., Ikeda, Y., Jamin, S.P., Zhao, L., De Rooij, D.G., Themmen, A.P., Behringer, R.R., Parker, K.L. Mol. Endocrinol. (2004)
- Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. Ikeda, Y., Swain, A., Weber, T.J., Hentges, K.E., Zanaria, E., Lalli, E., Tamai, K.T., Sassone-Corsi, P., Lovell-Badge, R., Camerino, G., Parker, K.L. Mol. Endocrinol. (1996)
- Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Lala, D.S., Rice, D.A., Parker, K.L. Mol. Endocrinol. (1992)
- Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1. Babu, P.S., Bavers, D.L., Beuschlein, F., Shah, S., Jeffs, B., Jameson, J.L., Hammer, G.D. Endocrinology (2002)
- Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response. Bland, M.L., Jamieson, C.A., Akana, S.F., Bornstein, S.R., Eisenhofer, G., Dallman, M.F., Ingraham, H.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Tissue-specific knockouts of steroidogenic factor 1. Zhao, L., Bakke, M., Hanley, N.A., Majdic, G., Stallings, N.R., Jeyasuria, P., Parker, K.L. Mol. Cell. Endocrinol. (2004)
- Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development. Arango, N.A., Lovell-Badge, R., Behringer, R.R. Cell (1999)
- A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Luo, X., Ikeda, Y., Parker, K.L. Cell (1994)
- Tpit determines alternate fates during pituitary cell differentiation. Pulichino, A.M., Vallette-Kasic, S., Tsai, J.P., Couture, C., Gauthier, Y., Drouin, J. Genes Dev. (2003)
- Hypomorphic phenotype in mice with pituitary-specific knockout of steroidogenic factor 1. Zhao, L., Bakke, M., Krimkevich, Y., Cushman, L.J., Parlow, A.F., Camper, S.A., Parker, K.L. Genesis (2001)
- Synergy of SF1 and RAR in activation of Oct-3/4 promoter. Barnea, E., Bergman, Y. J. Biol. Chem. (2000)
- Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression. Katoh-Fukui, Y., Owaki, A., Toyama, Y., Kusaka, M., Shinohara, Y., Maekawa, M., Toshimori, K., Morohashi, K. Blood (2005)
- Development of a transgenic green fluorescent protein lineage marker for steroidogenic factor 1. Stallings, N.R., Hanley, N.A., Majdic, G., Zhao, L., Bakke, M., Parker, K.L. Mol. Endocrinol. (2002)
- LXXLL-related motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1. Suzuki, T., Kasahara, M., Yoshioka, H., Morohashi, K., Umesono, K. Mol. Cell. Biol. (2003)
- Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression. Halvorson, L.M., Ito, M., Jameson, J.L., Chin, W.W. J. Biol. Chem. (1998)
- The orphan nuclear receptor, steroidogenic factor 1, regulates neuronal nitric oxide synthase gene expression in pituitary gonadotropes. Wei, X., Sasaki, M., Huang, H., Dawson, V.L., Dawson, T.M. Mol. Endocrinol. (2002)
- Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Sadovsky, Y., Crawford, P.A., Woodson, K.G., Polish, J.A., Clements, M.A., Tourtellotte, L.M., Simburger, K., Milbrandt, J. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Winnay, J.N., Hammer, G.D. Mol. Endocrinol. (2006)
- Steroidogenic factor 1 (SF-1) and SP1 are required for regulation of bovine CYP11A gene expression in bovine luteal cells and adrenal Y1 cells. Liu, Z., Simpson, E.R. Mol. Endocrinol. (1997)
- The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Ingraham, H.A., Lala, D.S., Ikeda, Y., Luo, X., Shen, W.H., Nachtigal, M.W., Abbud, R., Nilson, J.H., Parker, K.L. Genes Dev. (1994)
- Steroidogenic factor-1 controls the aldose reductase akr1b7 gene promoter in transgenic mice through an atypical binding site. Martinez, A., Val, P., Sahut-Barnola, I., Aigueperse, C., Veyssière, G., Lefrançois-Martinez, A.M. Endocrinology (2003)
- The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development. Wilson, M.J., Jeyasuria, P., Parker, K.L., Koopman, P. J. Biol. Chem. (2005)
- Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene. Jacobs, S.B., Coss, D., McGillivray, S.M., Mellon, P.L. Mol. Endocrinol. (2003)
- Murine relaxin-like factor promoter: functional characterization and regulation by transcription factors steroidogenic factor 1 and DAX-1. Koskimies, P., Levallet, J., Sipilä, P., Huhtaniemi, I., Poutanen, M. Endocrinology (2002)
- Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1. Dorn, C., Ou, Q., Svaren, J., Crawford, P.A., Sadovsky, Y. J. Biol. Chem. (1999)
- Pituitary homeobox 2 regulates adrenal4 binding protein/steroidogenic factor-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancer. Shima, Y., Zubair, M., Komatsu, T., Oka, S., Yokoyama, C., Tachibana, T., Hjalt, T.A., Drouin, J., Morohashi, K. Mol. Endocrinol. (2008)
- Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression. Pezzi, V., Sirianni, R., Chimento, A., Maggiolini, M., Bourguiba, S., Delalande, C., Carreau, S., Andò, S., Simpson, E.R., Clyne, C.D. Endocrinology (2004)
- Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function. Winnay, J.N., Xu, J., O'Malley, B.W., Hammer, G.D. Endocrinology (2006)
- Transcriptional regulation of the rat steroidogenic acute regulatory protein gene by steroidogenic factor 1. Sandhoff, T.W., Hales, D.B., Hales, K.H., McLean, M.P. Endocrinology (1998)
- Cholesterol side-chain cleavage cytochrome P450 gene expression in the primitive gut of the mouse embryo does not require steroidogenic factor 1. Keeney, D.S., Ikeda, Y., Waterman, M.R., Parker, K.L. Mol. Endocrinol. (1995)
- The mouse adrenocorticotropin receptor gene: cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor steroidogenic factor 1. Cammas, F.M., Pullinger, G.D., Barker, S., Clark, A.J. Mol. Endocrinol. (1997)