The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PERP  -  PERP, TP53 apoptosis effector

Homo sapiens

Synonyms: KCP-1, KCP1, KRTCAP1, Keratinocyte-associated protein 1, P53-induced protein PIGPC1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PERP


High impact information on PERP


Biological context of PERP


Anatomical context of PERP


Other interactions of PERP


Analytical, diagnostic and therapeutic context of PERP

  • PERP protein levels were assessed by Western blot analysis of 22 fresh-frozen tumors and by immunohistochemical analysis of 16 paraffin-embedded tumor specimens [1].


  1. Expression of p53-induced apoptosis effector PERP in primary uveal melanomas: Downregulation is associated with aggressive type. Paraoan, L., Gray, D., Hiscott, P., Ebrahimi, B., Damato, B., Grierson, I. Exp. Eye Res. (2006) [Pubmed]
  2. At the scene of ischemic brain injury: is PARP a perp? Choi, D.W. Nat. Med. (1997) [Pubmed]
  3. Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display. Salvatore, G., Beers, R., Margulies, I., Kreitman, R.J., Pastan, I. Clin. Cancer Res. (2002) [Pubmed]
  4. Human beta-defensin-2. Schröder, J.M., Harder, J. Int. J. Biochem. Cell Biol. (1999) [Pubmed]
  5. Focal adhesion kinase is expressed in acantholytic keratinocytes associated with pemphigus vulgaris and pemphigus foliaceus. Penneys, N.S. Br. J. Dermatol. (1996) [Pubmed]
  6. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Attardi, L.D., Reczek, E.E., Cosmas, C., Demicco, E.G., McCurrach, M.E., Lowe, S.W., Jacks, T. Genes Dev. (2000) [Pubmed]
  7. Keratinocytes-associated chemokines and enzymatically quiescent heparanase induce the binding of resting CD4+ T cells. Hershkoviz, R., Marikovsky, M., Gilat, D., Lider, O. J. Invest. Dermatol. (1996) [Pubmed]
  8. Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents. Gold, L.S., Backman, G.M., Hooper, N.K., Peto, R. Environ. Health Perspect. (1987) [Pubmed]
  9. Identification of THW, a putative new tumor suppressor gene. Hildebrandt, T., Preiherr, J., Tarbé, N., Klostermann, S., Van Muijen, G.N., Weidle, U.H. Anticancer Res. (2000) [Pubmed]
  10. In vitro and in vivo analysis of the major type I protein arginine methyltransferase from Trypanosoma brucei. Pelletier, M., Pasternack, D.A., Read, L.K. Mol. Biochem. Parasitol. (2005) [Pubmed]
  11. MR determination of hippocampal volume: comparison of three methods. Hasboun, D., Chantôme, M., Zouaoui, A., Sahel, M., Deladoeuille, M., Sourour, N., Duyme, M., Baulac, M., Marsault, C., Dormont, D. AJNR. American journal of neuroradiology. (1996) [Pubmed]
  12. Predominance of epidermal CD8+ T lymphocytes in bullous cutaneous reactions caused by beta-lactam antibiotics. Hertl, M., Bohlen, H., Jugert, F., Boecker, C., Knaup, R., Merk, H.F. J. Invest. Dermatol. (1993) [Pubmed]
  13. Loss of heterozygosity of gene THW is frequently found in melanoma metastases. Hildebrandt, T., van Dijk, M.C., van Muijen, G.N., Weidle, U.H. Anticancer Res. (2001) [Pubmed]
  14. Single-nucleotide polymorphisms in the p53 pathway. Harris, S.L., Gil, G., Hu, W., Robins, H., Bond, E., Hirshfield, K., Feng, Z., Yu, X., Teresky, A.K., Bond, G., Levine, A.J. Cold Spring Harb. Symp. Quant. Biol. (2005) [Pubmed]
  15. Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation. Luthra, R., Wu, T.T., Luthra, M.G., Izzo, J., Lopez-Alvarez, E., Zhang, L., Bailey, J., Lee, J.H., Bresalier, R., Rashid, A., Swisher, S.G., Ajani, J.A. J. Clin. Oncol. (2006) [Pubmed]
WikiGenes - Universities