The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Il3  -  interleukin 3

Rattus norvegicus

Synonyms: Hematopoietic growth factor, IL-3, Il-3, Interleukin-3, MCGF, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Il3

  • Genes coding for human interleukin-1 alpha and for rat interleukin-3 beta were transferred by injecting producer cells of recombinant adenovirus vectors into the tumour in attempts to achieve high concentrations of the cytokines inside the tumor without systemic toxicity [1].
  • IL-1/IL-3 gene therapy of non-small cell lung cancer (NSCLC) in rats using 'cracked' adenoproducer cells [1].
  • TUNEL (terminal deoxynucleotidyltransferase-mediated 2'-deoxyuridine 5'-triphosphate-biotin nick end labeling) staining revealed that IL-3 infusion caused a significant reduction in the number of CA1 neurons exhibiting DNA fragmentation 7 d after ischemia [2].
  • The BM at 24 hours shows a replenished reserve of mature neutrophils and a synergistic left-shifted myeloid hyperplasia as compared with IL-3 and G-CSF alone [3].
  • These results suggest production of a granulocyte-macrophage colony-stimulating factor or interleukin-3-like activity by highly metastatic 13762NF clones and implicate a possible role for colony-stimulating factors in regulating the metastatic potential of mammary adenocarcinoma cell clones [4].

Psychiatry related information on Il3


High impact information on Il3

  • Moreover, the mechanism(s) underlying the neurotrophic action of IL-3 has not been elucidated, although an erythroleukemic cell line is known to enter apoptosis after IL-3 starvation possibly due to a rapid decrease in Bcl-2 expression [2].
  • The neuroprotective action of IL-3 appeared to be mediated by a postischemic transient upregulation of the IL-3R alpha subunit in the hippocampal CA1 field where IL-3Ralpha was barely detectable under normal conditions [2].
  • IL-10 has previously been described to enhance mast cell development in the context of IL-3 and IL-4 [5].
  • In vitro, the recombinant protein bound specifically to AU-rich transcripts, including those for interleukin 3, granulocyte/macrophage colony-stimulating factor, c-fos, and c-myc [6].
  • Signal transduction by the receptors for thrombopoietin (c-mpL) and interleukin-3 in hematopoietic and nonhematopoietic cells [7].

Biological context of Il3


Anatomical context of Il3


Associations of Il3 with chemical compounds

  • It is known that IL-3 stimulates tyrosine phosphorylation while transducing a mitogenic signal [14].
  • Spirogermanium normalized these changes to various degrees, with the exception of the depressed IL-2 and IL-3 production [15].
  • In multiparameter ex vivo studies, untreated arthritic rats exhibited enhanced cyanine dye fluorescence in peripheral blood monocytes, enhanced interleukin (IL)-1 production by adherent spleen cells and depressed IL-2 and IL-3 production by splenic lymphocytes [15].
  • Spleen and thymus cells (5 x 10(6)/ml) were incubated for 48 h in the presence of 5 micrograms/ml of concanavalin A or 2 micrograms/ml of bacterial lipopolysaccharide to stimulate the production of IL-3 and IL-6 [16].
  • IL-3 does not affect the allergic airway responses and leukotriene production after allergen challenge in rats [17].

Other interactions of Il3


Analytical, diagnostic and therapeutic context of Il3


  1. IL-1/IL-3 gene therapy of non-small cell lung cancer (NSCLC) in rats using 'cracked' adenoproducer cells. Esandi, M.C., van Someren, G.D., Bout, A., Mulder, A.H., van Bekkum, D.W., Valerio, D., Noteboom, J.L. Gene Ther. (1998) [Pubmed]
  2. Interleukin 3 prevents delayed neuronal death in the hippocampal CA1 field. Wen, T.C., Tanaka, J., Peng, H., Desaki, J., Matsuda, S., Maeda, N., Fujita, H., Sato, K., Sakanaka, M. J. Exp. Med. (1998) [Pubmed]
  3. Acute and subacute hematologic effects of multi-colony stimulating factor in combination with granulocyte colony-stimulating factor in vivo. Ulich, T.R., del Castillo, J., McNiece, I.K., Yin, S.M., Irwin, B., Busser, K., Guo, K.Z. Blood (1990) [Pubmed]
  4. Highly metastatic 13762NF rat mammary adenocarcinoma cell clones stimulate bone marrow by secretion of granulocyte-macrophage colony-stimulating factor/interleukin-3 activity. McGary, C.T., Miele, M.E., Welch, D.R. Am. J. Pathol. (1995) [Pubmed]
  5. Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells. Marshall, J.S., Leal-Berumen, I., Nielsen, L., Glibetic, M., Jordana, M. J. Clin. Invest. (1996) [Pubmed]
  6. AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity. Nakagawa, J., Waldner, H., Meyer-Monard, S., Hofsteenge, J., Jenö, P., Moroni, C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Signal transduction by the receptors for thrombopoietin (c-mpL) and interleukin-3 in hematopoietic and nonhematopoietic cells. Morella, K.K., Bruno, E., Kumaki, S., Lai, C.F., Fu, J., Wang, H.M., Murray, L., Hoffman, R., Timour, M., Bénit, L. Blood (1995) [Pubmed]
  8. Cloning and expression of the rat interleukin-3 gene. Cohen, D.R., Hapel, A.J., Young, I.G. Nucleic Acids Res. (1986) [Pubmed]
  9. Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. Qi, X.J., Wildey, G.M., Howe, P.H. J. Biol. Chem. (2006) [Pubmed]
  10. Selective expression of potassium channels during mast cell differentiation. McCloskey, M.A., Qian, Y.X. J. Biol. Chem. (1994) [Pubmed]
  11. Calcium-dependent activation of nuclear factor regulated by interleukin 3/adenovirus E4 promoter-binding protein gene expression by calcineurin/nuclear factor of activated T cells and calcium/calmodulin-dependent protein kinase signaling. Nishimura, Y., Tanaka, T. J. Biol. Chem. (2001) [Pubmed]
  12. Effects of stem cell factor (kit-ligand) and interleukin-3 on the growth and serine proteinase expression of rat bone-marrow-derived or serosal mast cells. Haig, D.M., Huntley, J.F., MacKellar, A., Newlands, G.F., Inglis, L., Sangha, R., Cohen, D., Hapel, A., Galli, S.J., Miller, H.R. Blood (1994) [Pubmed]
  13. Mast cells enhance eosinophil survival in vitro: role of TNF-alpha and granulocyte-macrophage colony-stimulating factor. Levi-Schaffer, F., Temkin, V., Malamud, V., Feld, S., Zilberman, Y. J. Immunol. (1998) [Pubmed]
  14. Over-expression of protein tyrosine phosphatase 1 (PTP1) alters IL-3-dependent growth and tyrosine phosphorylation. Gelderloos, J.A., Anderson, S.M. Oncogene (1996) [Pubmed]
  15. Antiarthritic and immunoregulatory activity of spirogermanium. DiMartino, M.J., Lee, J.C., Badger, A.M., Muirhead, K.A., Mirabelli, C.K., Hanna, N. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  16. Influence of spaceflight on the production of interleukin-3 and interleukin-6 by rat spleen and thymus cells. Miller, E.S., Koebel, D.A., Sonnenfeld, G. J. Appl. Physiol. (1995) [Pubmed]
  17. IL-3 does not affect the allergic airway responses and leukotriene production after allergen challenge in rats. Du, T., Martin, J.G., Xu, L.J., Powell, W.S., Renzi, P.M. Eur. Respir. J. (1999) [Pubmed]
  18. Genomic structure and chromosomal location of the rat gene encoding the zinc finger transcription factor Kid-1. Witzgall, R., Volk, R., Yeung, R.S., Bonventre, J.V. Genomics (1994) [Pubmed]
  19. Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. Tanaka, J., Fujita, H., Matsuda, S., Toku, K., Sakanaka, M., Maeda, N. Glia (1997) [Pubmed]
  20. Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes. Yoshida, K., Gage, F.H. Brain Res. (1991) [Pubmed]
  21. Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats. Eynott, P.R., Xu, L., Bennett, B.L., Noble, A., Leung, S.Y., Nath, P., Groneberg, D.A., Adcock, I.M., Chung, K.F. Immunology (2004) [Pubmed]
  22. Cloning, biological characterization and high-level expression of rat interleukin-3 using recombinant adenovirus: description of a new splicing variant. del C Esandi, M., van Someren, G.D., van der Velde, I., van Bekkum, D.W., Valerio, D., Noteboom, J.L., Bout, A. Gene (1998) [Pubmed]
  23. Coculture of TCR peptide-specific T cells with basic protein-specific T cells inhibits proliferation, IL-3 mRNA, and transfer of experimental autoimmune encephalomyelitis. Offner, H., Vainiene, M., Celnik, B., Weinberg, A.D., Buenafe, A., Vandenbark, A.A. J. Immunol. (1994) [Pubmed]
  24. Expression and modulation of FcepsilonRIalpha and FcepsilonRIbeta in human blood basophils. Saini, S.S., Richardson, J.J., Wofsy, C., Lavens-Phillips, S., Bochner, B.S., Macglashan, D.W. J. Allergy Clin. Immunol. (2001) [Pubmed]
  25. Adenovirus-mediated interleukin 3 beta gene transfer by isolated limb perfusion inhibits growth of limb sarcoma in rats. de Wilt, J.H., Bout, A., Eggermont, A.M., van Tiel, S.T., de Vries, M.W., ten Hagen, T.L., de Roos, W.K., Valerio, D., van der Kaaden, M.E. Hum. Gene Ther. (2001) [Pubmed]
WikiGenes - Universities