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Gene Review

Pak1  -  p21 protein (Cdc42/Rac)-activated kinase 1

Rattus norvegicus

Synonyms: Alpha-PAK, PAK-1, Protein kinase MUK2, Serine/threonine-protein kinase PAK 1, p21-activated kinase 1, ...
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Disease relevance of Pak1


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Biological context of Pak1


Anatomical context of Pak1


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Physical interactions of Pak1


Enzymatic interactions of Pak1


Regulatory relationships of Pak1


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Analytical, diagnostic and therapeutic context of Pak1


  1. Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Ke, Y., Wang, L., Pyle, W.G., de Tombe, P.P., Solaro, R.J. Circ. Res. (2004) [Pubmed]
  2. Delineation of the Cdc42/Rac-binding domain of p21-activated kinase. Thompson, G., Owen, D., Chalk, P.A., Lowe, P.N. Biochemistry (1998) [Pubmed]
  3. PAK3 mutation in nonsyndromic X-linked mental retardation. Allen, K.M., Gleeson, J.G., Bagrodia, S., Partington, M.W., MacMillan, J.C., Cerione, R.A., Mulley, J.C., Walsh, C.A. Nat. Genet. (1998) [Pubmed]
  4. Expression of Rho-family GTPases (Rac, cdc42, RhoA) and their association with p-21 activated kinase in adult rat peripheral nerve. Terashima, T., Yasuda, H., Terada, M., Kogawa, S., Maeda, K., Haneda, M., Kashiwagi, A., Kikkawa, R. J. Neurochem. (2001) [Pubmed]
  5. Lysophosphatidic acid stimulates p21-activated kinase in vascular smooth muscle cells. Schmitz, U., Thömmes, K., Beier, I., Vetter, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  6. DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. McPhie, D.L., Coopersmith, R., Hines-Peralta, A., Chen, Y., Ivins, K.J., Manly, S.P., Kozlowski, M.R., Neve, K.A., Neve, R.L. J. Neurosci. (2003) [Pubmed]
  7. Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice. Hayashi, M.L., Choi, S.Y., Rao, B.S., Jung, H.Y., Lee, H.K., Zhang, D., Chattarji, S., Kirkwood, A., Tonegawa, S. Neuron (2004) [Pubmed]
  8. Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics. Nayal, A., Webb, D.J., Brown, C.M., Schaefer, E.M., Vicente-Manzanares, M., Horwitz, A.R. J. Cell Biol. (2006) [Pubmed]
  9. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. Daniels, R.H., Hall, P.S., Bokoch, G.M. EMBO J. (1998) [Pubmed]
  10. Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation. Sundberg-Smith, L.J., Doherty, J.T., Mack, C.P., Taylor, J.M. J. Biol. Chem. (2005) [Pubmed]
  11. Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival. Loucks, F.A., Le, S.S., Zimmermann, A.K., Ryan, K.R., Barth, H., Aktories, K., Linseman, D.A. J. Neurochem. (2006) [Pubmed]
  12. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. Manser, E., Chong, C., Zhao, Z.S., Leung, T., Michael, G., Hall, C., Lim, L. J. Biol. Chem. (1995) [Pubmed]
  13. Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Tang, Y., Chen, Z., Ambrose, D., Liu, J., Gibbs, J.B., Chernoff, J., Field, J. Mol. Cell. Biol. (1997) [Pubmed]
  14. Phosphorylation of cortactin by p21-activated kinase. Webb, B.A., Zhou, S., Eves, R., Shen, L., Jia, L., Mak, A.S. Arch. Biochem. Biophys. (2006) [Pubmed]
  15. Overexpression of cyclin D1 is associated with elevated levels of MAP kinases, Akt and Pak1 during diethylnitrosamine-induced progressive liver carcinogenesis. Parekh, P., Rao, K.V. Cell Biol. Int. (2007) [Pubmed]
  16. p21-Activated kinase-1 is necessary for depolarization-mediated neuronal survival. Johnson, K., D'Mello, S.R. J. Neurosci. Res. (2005) [Pubmed]
  17. Angiotensin II-induced stimulation of p21-activated kinase and c-Jun NH2-terminal kinase is mediated by Rac1 and Nck. Schmitz, U., Thömmes, K., Beier, I., Wagner, W., Sachinidis, A., Düsing, R., Vetter, H. J. Biol. Chem. (2001) [Pubmed]
  18. Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. Sakurada, K., Kato, H., Nagumo, H., Hiraoka, H., Furuya, K., Ikuhara, T., Yamakita, Y., Fukunaga, K., Miyamoto, E., Matsumura, F., Matsuo, Y.I., Naito, Y., Sasaki, Y. J. Biol. Chem. (2002) [Pubmed]
  19. EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. Deroanne, C., Vouret-Craviari, V., Wang, B., Pouysségur, J. J. Cell. Sci. (2003) [Pubmed]
  20. Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase. Takizawa, N., Koga, Y., Ikebe, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  21. Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1. Wirth, A., Schroeter, M., Kock-Hauser, C., Manser, E., Chalovich, J.M., De Lanerolle, P., Pfitzer, G. J. Physiol. (Lond.) (2003) [Pubmed]
  22. JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions. Rider, L., Shatrova, A., Feener, E.P., Webb, L., Diakonova, M. J. Biol. Chem. (2007) [Pubmed]
  23. Calcium-independent contraction and sensitization of airway smooth muscle by p21-activated protein kinase. McFawn, P.K., Shen, L., Vincent, S.G., Mak, A., Van Eyk, J.E., Fisher, J.T. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
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