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Gene Review

Casp6  -  caspase 6

Rattus norvegicus

Synonyms: Apoptotic protease Mch-2, CASP-6, Caspase-6, Mch2
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Disease relevance of Casp6


High impact information on Casp6

  • Furthermore, active caspase 6 is capable of processing and activating procaspase 3 in cellular extracts prepared from non-apoptotic CGCs, whereas caspase 3 failed to activate caspase 6 [4].
  • Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis [4].
  • At the time of deprivation, the addition of the irreversible, broad-spectrum caspase inhibitor zVADfmk or the cell permeable, caspase 6 inhibitor CP-VEID-cho can transiently suppress the appearance of apoptosis, including the early appearance of DNA fragmentation [4].
  • Temporal regulation of VEID-7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development [5].
  • Interestingly, inhibition of caspase-6 blocked TUNEL-negative cell death [6].

Biological context of Casp6


Anatomical context of Casp6


Associations of Casp6 with chemical compounds


Other interactions of Casp6


Analytical, diagnostic and therapeutic context of Casp6

  • RT-PCR products, when subcloned and sequenced, provided full-length cDNAs for ICE (1,209 bp) and CPP32 (786 bp) and partial cDNA products for Mch2 (561 bp) and Nedd2 (811 bp) [20].
  • Caspase 6 expression was examined using Western blot and immunohistochemistry [3].
  • Ischemic preconditioning ameliorated mitochondrial respiratory dysfunction by 50%, reduced reactive oxygen species generation by 38%, and suppressed mitochondrial lipid peroxidation by 36%, resulting in improvement of the mitochondrial membrane potential and prevention of cytochrome c release as well as caspase-6 activation [21].
  • Proteolysis and activation of caspases 3 and 7 as determined by immunoblotting and substrate-specific cleavage assay (DEVDase) preceded caspase-6 proteolysis and increased VEIDase activity following STS treatment [22].


  1. The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo. Eliassen, L.T., Berge, G., Leknessund, A., Wikman, M., Lindin, I., Løkke, C., Ponthan, F., Johnsen, J.I., Sveinbjørnsson, B., Kogner, P., Flaegstad, T., Rekdal, Ø. Int. J. Cancer (2006) [Pubmed]
  2. Cloning and expression of rat caspase-6 and its localization in renal ischemia/reperfusion injury. Singh, A.B., Kaushal, V., Megyesi, J.K., Shah, S.V., Kaushal, G.P. Kidney Int. (2002) [Pubmed]
  3. Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy. Narkilahti, S., Pitkänen, A. Neuroscience (2005) [Pubmed]
  4. Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis. Allsopp, T.E., McLuckie, J., Kerr, L.E., Macleod, M., Sharkey, J., Kelly, J.S. Cell Death Differ. (2000) [Pubmed]
  5. Temporal regulation of VEID-7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development. Foley, J.D., Rosenbaum, H., Griep, A.E. J. Biol. Chem. (2004) [Pubmed]
  6. Alternative programs of cell death in developing retinal tissue. Guimarães, C.A., Benchimol, M., Amarante-Mendes, G.P., Linden, R. J. Biol. Chem. (2003) [Pubmed]
  7. Toxicogenomic studies of the rat brain at an early time point following acute sarin exposure. Damodaran, T.V., Greenfield, S.T., Patel, A.G., Dressman, H.K., Lin, S.K., Abou-Donia, M.B. Neurochem. Res. (2006) [Pubmed]
  8. Identification of caspase-6 in rat blastocysts and its implication in the induction of apoptosis by high glucose. Hinck, L., Thissen, J.P., De Hertogh, R. Biol. Reprod. (2003) [Pubmed]
  9. Evidence that caspase-1 is a negative regulator of AMPA receptor-mediated long-term potentiation at hippocampal synapses. Lu, C., Wang, Y., Furukawa, K., Fu, W., Ouyang, X., Mattson, M.P. J. Neurochem. (2006) [Pubmed]
  10. Protein kinase C-beta II Is an apoptotic lamin kinase in polyomavirus-transformed, etoposide-treated pyF111 rat fibroblasts. Chiarini, A., Whitfield, J.F., Armato, U., Dal Pra, I. J. Biol. Chem. (2002) [Pubmed]
  11. Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. Henshall, D.C., Skradski, S.L., Meller, R., Araki, T., Minami, M., Schindler, C.K., Lan, J.Q., Bonislawski, D.P., Simon, R.P. Neurobiol. Dis. (2002) [Pubmed]
  12. Gene expression analysis of the rat testis after treatment with di(2-ethylhexyl) phthalate using cDNA microarray and real-time RT-PCR. Kijima, K., Toyosawa, K., Yasuba, M., Matsuoka, N., Adachi, T., Komiyama, M., Mori, C. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  13. Differential c-Fos and caspase expression following kainic acid excitotoxicity. Ferrer, I., López, E., Blanco, R., Rivera, R., Krupinski, J., Martí, E. Acta Neuropathol. (2000) [Pubmed]
  14. Caspase proteolysis of desmin produces a dominant-negative inhibitor of intermediate filaments and promotes apoptosis. Chen, F., Chang, R., Trivedi, M., Capetanaki, Y., Cryns, V.L. J. Biol. Chem. (2003) [Pubmed]
  15. Sequential NO production by mitochondria and endoplasmic reticulum during induced apoptosis. Bustamante, J., Bersier, G., Badin, R.A., Cymeryng, C., Parodi, A., Boveris, A. Nitric Oxide (2002) [Pubmed]
  16. Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells. Capano, M., Virji, S., Crompton, M. Biochem. J. (2002) [Pubmed]
  17. Antioxidative treatment prevents activation of death-receptor- and mitochondrion-dependent apoptosis in the hearts of diabetic rats. Bojunga, J., Nowak, D., Mitrou, P.S., Hoelzer, D., Zeuzem, S., Chow, K.U. Diabetologia (2004) [Pubmed]
  18. Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI). D'Agostini, F., Izzotti, A., Bennicelli, C., Camoirano, A., Tampa, E., De Flora, S. Carcinogenesis (2002) [Pubmed]
  19. Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung. Auten, R.L., Whorton, M.H., Nicholas Mason, S. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  20. Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury. Kaushal, G.P., Singh, A.B., Shah, S.V. Am. J. Physiol. (1998) [Pubmed]
  21. Ischemic preconditioning attenuates ischemia-reperfusion-induced mucosal apoptosis by inhibiting the mitochondria-dependent pathway in rat small intestine. Wu, B., Ootani, A., Iwakiri, R., Fujise, T., Tsunada, S., Toda, S., Fujimoto, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  22. Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis. Meller, R., Skradski, S.L., Simon, R.P., Henshall, D.C. Neurosci. Lett. (2002) [Pubmed]
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