Gene Review:
Ireb2 - iron responsive element binding protein 2
Mus musculus
Synonyms:
D9Ertd85e, IRE-BP 2, IRP2, Iron regulatory protein 2, Iron-responsive element-binding protein 2, ...
- Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S.K., Miller, G., Abu-Asab, M., Tsokos, M., Switzer, R., Grinberg, A., Love, P., Tresser, N., Rouault, T.A. Nat. Genet. (2001)
- Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. Cooperman, S.S., Meyron-Holtz, E.G., Olivierre-Wilson, H., Ghosh, M.C., McConnell, J.P., Rouault, T.A. Blood (2005)
- Rare causes of hereditary iron overload. Ponka, P. Semin. Hematol. (2002)
- MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice. Grabill, C., Silva, A.C., Smith, S.S., Koretsky, A.P., Rouault, T.A. Brain Res. (2003)
- Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Galy, B., Hölter, S.M., Klopstock, T., Ferring, D., Becker, L., Kaden, S., Wurst, W., Gröne, H.J., Hentze, M.W. Nat. Genet. (2006)
- Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. Meyron-Holtz, E.G., Ghosh, M.C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U.V., Land, W., Ollivierre-Wilson, H., Grinberg, A., Love, P., Rouault, T.A. EMBO J. (2004)
- Nitrogen monoxide-mediated control of ferritin synthesis: implications for macrophage iron homeostasis. Kim, S., Ponka, P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line. Schalinske, K.L., Blemings, K.P., Steffen, D.W., Chen, O.S., Eisenstein, R.S. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Galy, B., Ferring, D., Minana, B., Bell, O., Janser, H.G., Muckenthaler, M., Schümann, K., Hentze, M.W. Blood (2005)
- IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice. Corna, G., Galy, B., Hentze, M.W., Cairo, G. J. Mol. Med. (2006)
- Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies. Smith, S.R., Cooperman, S., Lavaute, T., Tresser, N., Ghosh, M., Meyron-Holtz, E., Land, W., Ollivierre, H., Jortner, B., Switzer, R., Messing, A., Rouault, T.A. Ann. N. Y. Acad. Sci. (2004)
- Immunolocalization of iron regulatory protein expression in the murine central nervous system. Leibold, E.A., Gahring, L.C., Rogers, S.W. Histochem. Cell Biol. (2001)
- Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice. Salvatore, M.F., Fisher, B., Surgener, S.P., Gerhardt, G.A., Rouault, T. Brain Res. Mol. Brain Res. (2005)
- The nexus of iron and inflammation in hepcidin regulation: SMADs, STATs, and ECSIT. Milward, E., Johnstone, D., Trinder, D., Ramm, G., Olynyk, J. Hepatology (2007)
- Nitrosative and oxidative modulation of iron regulatory proteins. Bouton, C. Cell. Mol. Life Sci. (1999)
- Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: role of selective iron regulatory protein-2 downregulation. Recalcati, S., Taramelli, D., Conte, D., Cairo, G. Blood (1998)
- Differential modulation of the RNA-binding proteins IRP-1 and IRP-2 in response to iron. IRP-2 inactivation requires translation of another protein. Henderson, B.R., Kühn, L.C. J. Biol. Chem. (1995)
- Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2. Kim, S., Ponka, P. J. Biol. Chem. (1999)
- Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13. Weiss, G., Bogdan, C., Hentze, M.W. J. Immunol. (1997)
- Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes. Galy, B., Ferring, D., Hentze, M.W. Genesis (2005)