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Gene Review

SLC10A2  -  solute carrier family 10 (sodium/bile acid...

Homo sapiens

Synonyms: ASBT, Apical sodium-dependent bile acid transporter, IBAT, ISBT, Ileal Na(+)/bile acid cotransporter, ...
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Disease relevance of SLC10A2


High impact information on SLC10A2


Biological context of SLC10A2


Anatomical context of SLC10A2


Associations of SLC10A2 with chemical compounds


Physical interactions of SLC10A2


Regulatory relationships of SLC10A2


Other interactions of SLC10A2


Analytical, diagnostic and therapeutic context of SLC10A2

  • Two distinct epitopes, hemagglutinin (HA) and FLAG, were individually inserted by inverted PCR mutagenesis at strategic positions along the hASBT sequence [8].
  • Confocal microscopy confirmed membrane localization of epitope-tagged hASBT in saponin-treated (permeabilized) and nonpermeabilized transfected COS-1 and MDCK cells [8].
  • The ASBT, FXR, and PPARalpha genes in the affected and unaffected family members were analyzed using single stranded conformation polymorphism (SSCP), denaturing HPLC, and direct sequencing [18].
  • PATIENTS AND METHODS: ASBT expression in ileal biopsies from patients with Crohn's disease and from healthy subjects was quantified by western blot [16].
  • ASBT promoter function was studied in luciferase assays and by electrophoretic mobility shift assay [16].


  1. Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia. Love, M.W., Craddock, A.L., Angelin, B., Brunzell, J.D., Duane, W.C., Dawson, P.A. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  2. Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. Bergheim, I., Harsch, S., Mueller, O., Schimmel, S., Fritz, P., Stange, E.F. J. Lipid Res. (2006) [Pubmed]
  3. An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas. Wang, W., Xue, S., Ingles, S.A., Chen, Q., Diep, A.T., Frankl, H.D., Stolz, A., Haile, R.W. Cancer Epidemiol. Biomarkers Prev. (2001) [Pubmed]
  4. Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity. Chen, F., Ananthanarayanan, M., Emre, S., Neimark, E., Bull, L.N., Knisely, A.S., Strautnieks, S.S., Thompson, R.J., Magid, M.S., Gordon, R., Balasubramanian, N., Suchy, F.J., Shneider, B.L. Gastroenterology (2004) [Pubmed]
  5. Intestinal bile acid transport: biology, physiology, and pathophysiology. Shneider, B.L. J. Pediatr. Gastroenterol. Nutr. (2001) [Pubmed]
  6. c-Fos is a critical mediator of inflammatory-mediated repression of the apical sodium-dependent bile acid transporter. Neimark, E., Chen, F., Li, X., Magid, M.S., Alasio, T.M., Frankenberg, T., Sinha, J., Dawson, P.A., Shneider, B.L. Gastroenterology (2006) [Pubmed]
  7. Bile acid-induced negative feedback regulation of the human ileal bile acid transporter. Neimark, E., Chen, F., Li, X., Shneider, B.L. Hepatology (2004) [Pubmed]
  8. Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains. Banerjee, A., Swaan, P.W. Biochemistry (2006) [Pubmed]
  9. Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33. Wong, M.H., Rao, P.N., Pettenati, M.J., Dawson, P.A. Genomics (1996) [Pubmed]
  10. The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism. Eloranta, J.J., Jung, D., Kullak-Ublick, G.A. Mol. Endocrinol. (2006) [Pubmed]
  11. Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha. Jung, D., Fried, M., Kullak-Ublick, G.A. J. Biol. Chem. (2002) [Pubmed]
  12. Transmembrane Domain VII of the Human Apical Sodium-Dependent Bile Acid Transporter ASBT (SLC10A2) Lines the Substrate Translocation Pathway. Hussainzada, N., Banerjee, A., Swaan, P.W. Mol. Pharmacol. (2006) [Pubmed]
  13. Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94. Root, C., Smith, C.D., Sundseth, S.S., Pink, H.M., Wilson, J.G., Lewis, M.C. J. Lipid Res. (2002) [Pubmed]
  14. Bile acid transport and regulating functions in the human biliary epithelium. Chignard, N., Mergey, M., Veissière, D., Parc, R., Capeau, J., Poupon, R., Paul, A., Housset, C. Hepatology (2001) [Pubmed]
  15. Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption. Montagnani, M., Love, M.W., Rössel, P., Dawson, P.A., Qvist, P. Scand. J. Gastroenterol. (2001) [Pubmed]
  16. Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. Jung, D., Fantin, A.C., Scheurer, U., Fried, M., Kullak-Ublick, G.A. Gut (2004) [Pubmed]
  17. Inhibition of both the apical sodium-dependent bile acid transporter and HMG-CoA reductase markedly enhances the clearance of LDL apoB. Telford, D.E., Edwards, J.Y., Lipson, S.M., Sutherland, B., Barrett, P.H., Burnett, J.R., Krul, E.S., Keller, B.T., Huff, M.W. J. Lipid Res. (2003) [Pubmed]
  18. Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption. Montagnani, M., Abrahamsson, A., Galman, C., Eggertsen, G., Marschall, H.U., Ravaioli, E., Einarsson, C., Dawson, P.A. World J. Gastroenterol. (2006) [Pubmed]
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