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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Adenomatous Polyps

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Disease relevance of Adenomatous Polyps


Psychiatry related information on Adenomatous Polyps


High impact information on Adenomatous Polyps


Chemical compound and disease context of Adenomatous Polyps


Biological context of Adenomatous Polyps


Anatomical context of Adenomatous Polyps


Gene context of Adenomatous Polyps

  • The immunostaining studies revealed a significant correlation between high p27Kip1 protein expression and high cyclin D1 expression in the adenomatous polyps and in the subset of carcinomas that had only nuclear p27Kip1 expression [26].
  • Hypermethylation of the promoter of hMLH1, consequent loss of hMLH1 expression, and MSI are at the basis of approximately 25% of adenomatous polyps developed in subjects with a SFDR affected by colorectal cancer [27].
  • One hyperplastic and seven adenomatous polyps with villous architecture displayed foci of diffuse and intestinal-type carcinoma, respectively; in all of these cases, MUC1 expression and signs of gastric differentiation were observed in both the non-malignant and the carcinomatous component [28].
  • Immunohistochemical analysis showed that expression of both MSH2 and MSH6 proteins was lost in the cancer cells of the 2 mutation carriers but only MSH6 protein expression was lost in 2 adenomatous polyps [29].
  • Our results suggest chromosomal aberrations contribute early to the progression of adenomatous polyps after biallelic APC inactivation [30].

Analytical, diagnostic and therapeutic context of Adenomatous Polyps


  1. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Aoki, K., Tamai, Y., Horiike, S., Oshima, M., Taketo, M.M. Nat. Genet. (2003) [Pubmed]
  2. Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli. Okamoto, M., Sasaki, M., Sugio, K., Sato, C., Iwama, T., Ikeuchi, T., Tonomura, A., Sasazuki, T., Miyaki, M. Nature (1988) [Pubmed]
  3. MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps. Wang, L., Baudhuin, L.M., Boardman, L.A., Steenblock, K.J., Petersen, G.M., Halling, K.C., French, A.J., Johnson, R.A., Burgart, L.J., Rabe, K., Lindor, N.M., Thibodeau, S.N. Gastroenterology (2004) [Pubmed]
  4. Expression of variant CD44-messenger RNA in colorectal adenocarcinomas and adenomatous polyps in humans. Imazeki, F., Yokosuka, O., Yamaguchi, T., Ohto, M., Isono, K., Omata, M. Gastroenterology (1996) [Pubmed]
  5. Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism. Gryfe, R., Di Nicola, N., Lal, G., Gallinger, S., Redston, M. Am. J. Hum. Genet. (1999) [Pubmed]
  6. Association of serum lipids and glucose with the risk of colorectal adenomatous polyp in men: a case-control study in Korea. Park, S.K., Joo, J.S., Kim, D.H., Kim, Y.E., Kang, D., Yoo, K.Y. J. Korean Med. Sci. (2000) [Pubmed]
  7. Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine. Iinuma, T., Homma, S., Noda, T., Kufe, D., Ohno, T., Toda, G. J. Clin. Invest. (2004) [Pubmed]
  8. Computed tomographic virtual colonoscopy computer-aided polyp detection in a screening population. Summers, R.M., Yao, J., Pickhardt, P.J., Franaszek, M., Bitter, I., Brickman, D., Krishna, V., Choi, J.R. Gastroenterology (2005) [Pubmed]
  9. Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Marten, K., Bremer, C., Khazaie, K., Sameni, M., Sloane, B., Tung, C.H., Weissleder, R. Gastroenterology (2002) [Pubmed]
  10. Inward growth of colonic adenomatous polyps. Moss, S.F., Liu, T.C., Petrotos, A., Hsu, T.M., Gold, L.I., Holt, P.R. Gastroenterology (1996) [Pubmed]
  11. Differential activation of ornithine decarboxylase and tyrosine kinase in the rectal mucosa of patients with hyperplastic and adenomatous polyps. Colarian, J., Arlow, F.L., Calzada, R., Luk, G.D., Majumdar, A.P. Gastroenterology (1991) [Pubmed]
  12. Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers. Hirai, K., Ueda, K., Hayaishi, O. Cancer Res. (1983) [Pubmed]
  13. Effects of sulindac on sporadic colorectal adenomatous polyps. Matsuhashi, N., Nakajima, A., Fukushima, Y., Yazaki, Y., Oka, T. Gut (1997) [Pubmed]
  14. Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2. Pugh, S., Thomas, G.A. Gut (1994) [Pubmed]
  15. Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study. Arber, N., Kuwada, S., Leshno, M., Sjodahl, R., Hultcrantz, R., Rex, D. Gut (2006) [Pubmed]
  16. Chromosomal instability in MYH- and APC-mutant adenomatous polyps. Cardoso, J., Molenaar, L., de Menezes, R.X., van Leerdam, M., Rosenberg, C., Möslein, G., Sampson, J., Morreau, H., Boer, J.M., Fodde, R. Cancer Res. (2006) [Pubmed]
  17. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. De Marzo, A.M., Marchi, V.L., Yang, E.S., Veeraswamy, R., Lin, X., Nelson, W.G. Cancer Res. (1999) [Pubmed]
  18. Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways. Slice, L.W., Chiu, T., Rozengurt, E. J. Biol. Chem. (2005) [Pubmed]
  19. Detection of aberrant p16 methylation in the serum of colorectal cancer patients. Zou, H.Z., Yu, B.M., Wang, Z.W., Sun, J.Y., Cang, H., Gao, F., Li, D.H., Zhao, R., Feng, G.G., Yi, J. Clin. Cancer Res. (2002) [Pubmed]
  20. Aberrant expression of MUC5AC and MUC6 gastric mucin genes in colorectal polyps. Bartman, A.E., Sanderson, S.J., Ewing, S.L., Niehans, G.A., Wiehr, C.L., Evans, M.K., Ho, S.B. Int. J. Cancer (1999) [Pubmed]
  21. Cell type-specific autoregulation of the Caudal-related homeobox gene Cdx-2/3. Xu, F., Li, H., Jin, T. J. Biol. Chem. (1999) [Pubmed]
  22. Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers. Bezrookove, V., Smits, R., Moeslein, G., Fodde, R., Tanke, H.J., Raap, A.K., Darroudi, F. Genes Chromosomes Cancer (2003) [Pubmed]
  23. Conserved expression of intestinal trefoil factor in the human colonic adenoma-carcinoma sequence. Taupin, D., Ooi, K., Yeomans, N., Giraud, A. Lab. Invest. (1996) [Pubmed]
  24. Pitfalls in scintigraphic detection of neuroendocrine tumours. Feggi, L., Degli Uberti, E., Pansini, G.C., Transforini, G., Prandini, N., Ambrosio, M.R., D'Urso, A.R., Faggioli, R. European journal of nuclear medicine. (1992) [Pubmed]
  25. Recurrent polyps in the ileo-anal pouch or rectum in familial adenomatous polyposis. Tytgat, G.N., Gopinath, N. Eur. J. Cancer (1995) [Pubmed]
  26. Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. Ciaparrone, M., Yamamoto, H., Yao, Y., Sgambato, A., Cattoretti, G., Tomita, N., Monden, T., Rotterdam, H., Weinstein, I.B. Cancer Res. (1998) [Pubmed]
  27. Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer. Ricciardiello, L., Goel, A., Mantovani, V., Fiorini, T., Fossi, S., Chang, D.K., Lunedei, V., Pozzato, P., Zagari, R.M., De Luca, L., Fuccio, L., Martinelli, G.N., Roda, E., Boland, C.R., Bazzoli, F. Cancer Res. (2003) [Pubmed]
  28. Patterns of expression of trefoil peptides and mucins in gastric polyps with and without malignant transformation. Nogueira, A.M., Machado, J.C., Carneiro, F., Reis, C.A., Gött, P., Sobrinho-Simões, M. J. Pathol. (1999) [Pubmed]
  29. MSH6 germline mutations are rare in colorectal cancer families. Peterlongo, P., Nafa, K., Lerman, G.S., Glogowski, E., Shia, J., Ye, T.Z., Markowitz, A.J., Guillem, J.G., Kolachana, P., Boyd, J.A., Offit, K., Ellis, N.A. Int. J. Cancer (2003) [Pubmed]
  30. Somatic mutations in familial adenomatous polyps. Nuclear translocation of beta-catenin requires more than biallelic APC inactivation. Bläker, H., Scholten, M., Sutter, C., Otto, H.F., Penzel, R. Am. J. Clin. Pathol. (2003) [Pubmed]
  31. Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. Ulrich, C.M., Bigler, J., Bostick, R., Fosdick, L., Potter, J.D. Cancer Res. (2002) [Pubmed]
  32. Effect of folate supplementation on mucosal cell proliferation in high risk patients for colon cancer. Khosraviani, K., Weir, H.P., Hamilton, P., Moorehead, J., Williamson, K. Gut (2002) [Pubmed]
  33. Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse. Ritland, S.R., Leighton, J.A., Hirsch, R.E., Morrow, J.D., Weaver, A.L., Gendler, S.J. Clin. Cancer Res. (1999) [Pubmed]
  34. Effect of dietary calcium on colon carcinogenesis induced by a single injection of 1,2-dimethylhydrazine in rats. Karkare, M.R., Clark, T.D., Glauert, H.P. J. Nutr. (1991) [Pubmed]
  35. Elevated serum gastrin levels in patients with colorectal neoplasia. Seitz, J.F., Giovannini, M., Gouvernet, J., Gauthier, A.P. J. Clin. Gastroenterol. (1991) [Pubmed]
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