Disease relevance of BTF3L1

• This is made more likely by the realisation that the RANK-L/OPG pathway is also thought to mediate the calcification of vascular smooth muscle cells in coronary and peripheral vascular disease [1].
• Thus, OPG was as sensitive as supraorbital Doppler and more sensitive than supratrochlear Doppler in detecting hemodynamically significant ICA stenoses, without the unacceptable false-positive rate observed with the supraorbital Doppler test [2].
• The recent elucidation of the RANK/RANK-ligand/OPG pathway and its role as the final effector of osteoclastogenesis and bone resorption has brought a tremendous understanding of the pathophysiology of inflammatory bone loss, and has heightened expectation of a novel intervention [3].
• Twenty-two of 53 (42%) with a negative OPG had a DU, 4 of whom had >/=50% stenosis (1 thrombosis) that was confirmed by exploration [4].
• PATIENTS AND METHODS: Fifty-three patients with neurologic deficits that were noticed after CEA in the operating or recovery room had immediate OPG/Gee [4].

High impact information on BTF3L1

• Carotid artery status was assessed by direct continuous wave Doppler and Gee OPG at three to six months and again at one year postoperatively [5].
• The OPG was normal in 95% of cases in which the diameter of the lumen of the internal carotid artery (ICA) was less than 60% reduced; the ocular pulse was delayed in 86% of cases with ICA stenosis of 60% or more [2].
• Therefore we measured serum OPG levels in patients with coronary artery disease, compared the serum OPG levels among the different groups according to the number of stenotic vessels and determined whether there was any correlation with aortic calcification, LV (left ventricular) mass index and serum CRP (C-reactive protein) levels [6].
• Grade III laryngoscopy was present in 6% in LPG and 7.1% in OPG [7].
• The receptor activator of nuclear factor-kappa B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) pathway has been recently recognized as the final, dominant mediator of osteoclast proliferation and activation [8].

Chemical compound and disease context of BTF3L1

• Obstructive sleep apnea was present in 4.8% in LPG vs 6.1% in OPG [7].
• In this study, by using His6-tagged protein Fab OPG C11 from Escherichia coli fermentation as a model, we found that the presence of low concentrations of EDTA-Mg2+ in feed streams weakens the adsorption but makes it more specific towards polyhistidine tag [9].
• The relationship between bone-loss of steroid-induced osteonecrosis and local expression of OPG/OCIF [10].

Biological context of BTF3L1

• Two novel cucurbitacins, neocucurbitacins A and B, from the Brazilian folk medicine "Buchinha" (Luffa operculata) and their effect on PEBP2alphaA and OCIF gene expression in a human osteoblast-like Saos-2 cell line [11].
• There was found a significantly negative correlation between serum TRAP and bone mineral density (BMD) and also between serum OCIF/OPG and bone mineral density [12].
• The T(950)-C and G(1181)-C polymorphisms were in strong linkage disequilibrium with each other but not with the A(163)-G polymorphism further upstream in the OPG promoter [13].
• Two novel cucurbitacins designated as neocucurbitacins A (1), possessing inhibitory activity of polyoma enhancer binding protein 2alphaA (PEBP2alphaA) and osteoclastogenesis-inhibitory factor (OCIF) gene expression in human osteoblast-like cells, and B (2) were isolated from the fruit of Luffa operculata [11].
• Immediately after each OPG test a brachial systolic pressure (BSP) was measured with a stethoscope, cuff and manometer [14].

Anatomical context of BTF3L1

• In conclusion, serum OPG level was related to the severity of stenotic coronary arteries and serum CRP levels [6].
• Significant differences in ophthalmic artery pressures as measured by oculopneumoplethysmography (OPPG), and significant delays in ocular pulse arrival time combined with characteristic recorded bruits as determined by oculoplethysmography/carotid phonoangiography (OPG/CPA) were considered as an index of carotid stenosis [15].
• The concentration of OPG/OCIF in synovial fluid increased with severity of knee OA and was significantly higher in individuals with OA of grade IV than in those with OA of grade 0 or grade 1 [16].
• Gliomas of the hypothalamus and optic pathways (H/OPG) comprise 5% of pediatric intracranial tumors, present most frequently in patients younger than age 5 years, and may have a more aggressive course in younger children [17].
• It may also regulate osteoclast formation through OPG/OCIF in periodontal ligament cells [18].

Associations of BTF3L1 with chemical compounds

• Awake fiberoptic intubation was performed in 3.6% in LPG and 1.5% in OPG [7].
• By combining EDTA-Mg2+ treatment and periplasmic extraction, we developed a one-step purification procedure for His6-tagged recombinant Fab OPG C11 using Ni-IDA (iminodiacetic acid) chromatography [9].
• Moreover, 13 of 15 bacteria (87%) that occurred during OPG were resistant to gentamicin [19].
• Despite its reduction of bacterial colonization rates of pharyngeal and tracheal secretions, OPG did not seem to offer additional clinical benefits in long-term mechanically ventilated patients on stress ulcer prophylaxis with sucralfate [19].

Analytical, diagnostic and therapeutic context of BTF3L1

• BACKGROUND: This study analyzes the role of oculopneumoplethysmography (OPG/Gee) in detecting acute carotid thrombosis (CAT) after carotid endarterectomy (CEA) in a timely fashion for immediate exploration, and minimizing unnecessary surgery [4].
• Serum OPG levels were measured by ELISA [6].
• Early postoperative complications (prolonged mechanical ventilation, unplanned ICU admission, sepsis, re-operation) occurred more frequently in OPG, but the difference between the two groups was statistically insignificant (P<0.08) [7].
• Immobilized metal-ion affinity chromatography of recombinant Fab protein OPG C11 in the presence of EDTA-Mg(II) [9].
• The length of hospitalization was 3.8+/-1.4 days in LPG and 6.2+/-6.6 in OPG (P<0.01) [7].

References