Disease relevance of Ophthalmic Artery

• Monocular blindness developed in one patient because of papaverine infusion near the ophthalmic artery [1].
• Due to the possible involvement of endothelin in headache disorders, the objective of this study was to verify the effects of lithium and cyclooxygenase inhibitors (indomethacin, acetylsalicylic acid and naproxen) on endothelin-1 (ET-1)-induced contractions in isolated human temporal arteries and porcine ophthalmic arteries [2].
• Given the potential role of vasoregulatory peptides in the ocular-forehead circulation in the pathophysiology of vascular headaches, the interactions between substance P and endothelin-1 over time were studied in isolated porcine ophthalmic artery [3].
• Radiological examination revealed an enlargement of the hypophysis whereas the right C4 aneurysm had decreased in size and no blood flow was apparent in the ipsilateral ophthalmic artery [4].
• The main factor responsible for this improvement has been the recognition that, in neovascular glaucoma, the retinal blood vessels are not capable of autoregulation of calibre in response to changes in intraocular pressure and ophthalmic artery perfusion pressure [5].

High impact information on Ophthalmic Artery

• N(G)-monomethyl-L-arginine decreased fundus pulsations and blood flow velocity in the ophthalmic artery and increased blood pressure in healthy subjects [6].
• Furthermore, patients with reversed flow in the ophthalmic artery had low mean preoperative CO2 reactivity on the same side [7].
• Blood flow velocity in the middle cerebral artery and the ophthalmic artery, as well as ocular fundus pulsations and systemic hemodynamic parameters, were measured after sumatriptan and placebo and during the following infusion of nitroglycerin [8].
• In contrast, sumatriptan had no effect in the ophthalmic artery [8].
• Myogenic tone and reactivity of rat ophthalmic artery in acute exposure to high glucose and in a type II diabetic model [9].

Biological context of Ophthalmic Artery

• The present study is an attempt to assess sumatriptan's vasoactivity in isolated porcine ophthalmic artery (POA) and to verify whether it has similar activity to 5HT, and whether it interferes with the vasodilation induced by calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) [10].
• In summary, injection of amytal in the internal carotid artery below the origin of the ophthalmic artery, but not above it, can impair visual acuity and in some cases, entirel suppress the vision in the EII secondary to retinal suppression [11].
• Blood pressure, pulse rate, and ophthalmic artery blood flow velocity showed only minor changes during and after administration of L-NMMA [12].
• Both periarterial electrical stimulation (ES) and intraluminal application of norepinephrine (NE) produced a vasoconstriction in the isolated canine ophthalmic artery (OA) [13].
• It was observed that the elevated perfusion pressure was associated with an increased vascular resistance and a constant mean blood velocity in the ophthalmic artery and iridal vessels [14].

Anatomical context of Ophthalmic Artery

• In the permeabilized ophthalmic artery smooth muscle, 5-HT enhanced the contractile response to constant cytosolic Ca2+ (pCa 6.5) in the presence of guanosine triphosphate (GTP, 10 microM), but not in its absence [15].
• Effects of adrenomedullin on ocular hemodynamic parameters in the choroid and the ophthalmic artery [16].
• METHOD: The blood velocity in the ophthalmic artery (OA), the central retinal vein (CRV), and artery (CRA) was measured by pulsed Doppler sonography (4-Mhz probe) [17].
• In the present hyperoxic conditions, the vascular effect of sevoflurane may have been limited in the central retinal artery and not in the ophthalmic artery [18].
• The use of a latex calibrated-leak balloon positioned above the ophthalmic artery in the internal carotid artery or in one of its branches appears to circumvent the ocular complications mentioned [19].

Associations of Ophthalmic Artery with chemical compounds

• By contrast, the basal release of NO became less efficient in inhibiting contractions to serotonin and endothelin-1 in ciliary versus ophthalmic artery [20].
• The results show that in the human ophthalmic artery, nitric oxide is released under basal conditions and that its production can be markedly stimulated by bradykinin, acetylcholine, and particularly histamine, which cause profound vascular relaxation [21].
• The effects of topical timolol maleate 0.5% on the ophthalmic artery diastolic (OABPd), systolic (OABPs) and mean blood pressure (OABPm) were investigated in 19 healthy subjects using compression ophthalmodynamometry [22].
• Mechanisms of histamine-induced relaxation in external and internal ophthalmic arteries [23].
• To determine if nitric oxide (NO) is involved in the relaxant response to nerve stimulation by nicotine and electrical pulses in dog external ophthalmic arteries (EOA) and internal ophthalmic arteries (IOA) [24].

Gene context of Ophthalmic Artery

• Endothelium-derived nitric oxide (NO), which is catalysed by nitric oxide synthase (NOS), is a potent modulator of vascular tone in the human ophthalmic artery, which is normally in a state of constant vasodilation due to the actions of NO [25].
• CONCLUSION: We concluded that COPD is associated with impaired retrobulbar hemodynamics, especially in the ophthalmic artery [26].
• These findings demonstrate that in the human ophthalmic artery, endothelium-derived nitric oxide and endothelin are very potent modulators of vascular tone, suggesting that they play an important role in the regulation of local blood flow in the eye [21].
• RESULTS: Adrenomedullin dose dependently increased choroidal blood flow and flow velocity in the ophthalmic artery [16].
• METHODS: Rat ophthalmic arteries (diameter of 217 +/- 6 microm, n = 22) were isolated, cannulated with glass pipettes in an arteriograph and pressurized in a physiological buffer [27].

Analytical, diagnostic and therapeutic context of Ophthalmic Artery

• Color Doppler ultrasonography was used to measure the impedance to flow (pulsatility index) within the uterine, central retinal, and ophthalmic arteries in the 17beta-estradiol phase at baseline and after 3, 12, and 15 months [28].
• A cadaver dissection study, with red colored latex injection into the ophthalmic artery, is in progress [29].
• Effect of prostaglandin E1 on ophthalmic artery velocimetry in a pre-eclamptic woman with visual disturbance caused by retinal arterial narrowing [30].
• They also had preoperatively either EEG changes or a Collateral Ophthalmic Artery Pressure, as measured with OPG compression tests, lower than 30 mm Hg, or both criteria [31].

References