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Gene Review

RNF217-AS1  -  RNF217 antisense RNA 1 (head to head)

Homo sapiens

Synonyms: STL
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Disease relevance of STL

  • METHODS: Tissues were obtained from 22 pregnant ewes under halothane anesthesia: early controls at 131 days' gestational age (dGA) not in labor (ECNL; n = 6); during cortisol-induced premature labor (CPL at 131 dGA; n = 6); in term spontaneous labor (STL at 140-145 dGA; n = 5); or term control animals not in labor (TCNL at 140-145 dGA; n = 5) [1].
  • With disease progression, STL and SSF increased significantly, whereas PRF showed a steady decrease from diagnosis to blast crisis [2].
  • We utilize a measure of brain dynamics, namely the short-term largest Lyapunov exponent (STL/sub max/) to evaluate the efficacy of treatment in epileptic animals and humans with known antiepileptic drugs (AED) like diazepam and phenobarbital during status epilepticus (SE) [3].

High impact information on STL

  • Postprandial triglyceridemia was significantly greater after subjects consumed the LCT diet than it was after they consumed either the STL or MCT diets, which were similar [4].
  • Short-term feeding of MCT and STL diets produces significant changes in lipid metabolism [4].
  • By 48 h, when morphological transformation was first observed, there had occurred a marked change in nuclear-cytoskeletal anchorage to the substratum, as evidenced by a difference in sensitivity of Triton-extracted STL and CTL monolayers to detachment by KI [5].
  • The high degree of sequence conservation, and the selective localization of the BR-STL message in brain, suggest an important function in the central nervous system [6].
  • A t(6;12)(q23;p13) results in the fusion of ETV6 to a novel gene, STL, in a B-cell ALL cell line [7].

Biological context of STL


Anatomical context of STL

  • The mean peak [Ca2+]i values in the paraphagosomal cytoplasm of neutrophils ingesting one particle of STZ, IGZ, C3Z, Z and STL were 536.1 +/- 57.6, 424.7 +/- 55.8, 373.8 +/- 62.7, 272.3 +/- 31.5, and 270.8 +/- 38.0 nM, respectively, which showed good correlation (r = 0.97) with the efficiency of the particles for inducing superoxide production [11].
  • Following on from this work, we consider WGA-, STL- and UEA-I-mediated drug delivery to be a promising approach for peroral bioadhesive formulations adhering to absorptive enterocytes [12].
  • Compared to the BSA-binding capacity of the cells, the extent of nonspecific binding was strongly dependent on the type of cell line and lectin under investigation being lower than 2% in the case of WGA, STL and UEA-I/Caco-2 and HT-29 cells [12].
  • Basal cells of the nonsensory epithelium were labelled with DSL, LEL, LCA, BSL-I and STL [13].
  • Bowman's glands in the lamina propria showed subpopulations of acinar cells reacting with SBA, S-WGA, WGA, STL, Con A, PSA, PNA, SJA, VVA, JAC and S-Con A, but in our optical studies with lectins we were unable to differentiate between mucous and serous cells in the way that is possible on electron microscopy [10].

Associations of STL with chemical compounds

  • The initial increase in plasma noradrenaline until STL was significantly higher in both the NTO (p less than 0.02) and BHO (p less than 0.005) compared to the control group [14].
  • The intracrystalline diffusivity of MTBE in natural water was much slower than that in deionized water, only 1/10 in STL and 1/3 in FS natural water, since the aperture entrances of mordenite was appreciably hindered by NOM [15].

Other interactions of STL

  • In contrast, myometrial PTHrP mRNA:18s ratio was decreased when TCNL and STL were compared with both ECNL and CPL groups (P < .05) [1].
  • The SFL in RA (67.8 +/- 31.1) and the STL in RA (77.2 +/- 93.2) were also significantly different [16].

Analytical, diagnostic and therapeutic context of STL

  • When cytoskeletal residues and KI-extracted proteins of STL and CTL cells were compared by two-dimensional polyacrylamide gel electrophoresis (PAGE), qualitative and quantitative differences were seen in a number of minor components [5].
  • The average difference between the conventional and the STL splints was 0.24 +/- 0.23 mm(2) [17].


  1. Parathyroid hormone-related protein mRNA in sheep endometrium and myometrium during late gestation and labor. Wu, W.X., Bruns, M.E., Bruns, D., Seaner, R., Nathanielsz, P.W., Ferguson, J.E. J. Soc. Gynecol. Investig. (1998) [Pubmed]
  2. Monitoring DNA cytometric parameters during the course of chronic myelogenous leukemia. Kropff, M., Chatelain, R., Muller, C.P., Wagner, A., Wenzler, T., Böhmer, H., Böcking, A. Anal. Quant. Cytol. Histol. (1991) [Pubmed]
  3. Brain dynamical disentrainment by anti-epileptic drugs in rat and human status epilepticus. Good, L., Sabesan, S., Iasemidis, L., Tsakalis, K., Treiman, D. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference (2004) [Pubmed]
  4. Plasma lipids and lipoproteins during 6 d of maintenance feeding with long-chain, medium-chain, and mixed-chain triglycerides. Swift, L.L., Hill, J.O., Peters, J.C., Greene, H.L. Am. J. Clin. Nutr. (1992) [Pubmed]
  5. Changes in cell-substratum adhesion and nuclear-cytoskeletal anchorage during cytodifferentiation of BeWo choriocarcinoma cells. Friedman, S.J., Galuszka, D., Gedeon, I., Dewar, C.L., Skehan, P., Heckman, C.A. Exp. Cell Res. (1984) [Pubmed]
  6. Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. Falany, C.N., Xie, X., Wang, J., Ferrer, J., Falany, J.L. Biochem. J. (2000) [Pubmed]
  7. A t(6;12)(q23;p13) results in the fusion of ETV6 to a novel gene, STL, in a B-cell ALL cell line. Suto, Y., Sato, Y., Smith, S.D., Rowley, J.D., Bohlander, S.K. Genes Chromosomes Cancer (1997) [Pubmed]
  8. Harvesting and long term exposure effects in the relation between air pollution and mortality. Schwartz, J. Am. J. Epidemiol. (2000) [Pubmed]
  9. Identification of peptide mimetics of xenoreactive alpha-Gal antigenic epitope by phage display. Lang, J., Zhan, J., Xu, L., Yan, Z. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  10. Identification and localisation of glycoconjugates in the olfactory mucosa of the armadillo Chaetophractus villosus. Ferrari, C.C., Carmanchahi, P.D., Aldana Marcos, H.J., Mugnaini, M.T., Affanni, J.M., Paz, D.A. J. Anat. (1999) [Pubmed]
  11. Influence of type and opsonization of ingested particle on intracellular free calcium distribution and superoxide production by human neutrophils. Murata, T., Sullivan, J.A., Sawyer, D.W., Mandell, G.L. Infect. Immun. (1987) [Pubmed]
  12. Lectin-mediated bioadhesion: binding characteristics of plant lectins on the enterocyte-like cell lines Caco-2, HT-29 and HCT-8. Gabor, F., Stangl, M., Wirth, M. Journal of controlled release : official journal of the Controlled Release Society. (1998) [Pubmed]
  13. Characterisation of glycoconjugate sugar residues in the vomeronasal organ of the armadillo Chaetophractus villosus (Mammalia, Xenarthra). Carmanchahi, P.D., Ferrari, C.C., Marcos, H.J., Affanni, J.M., Sonez, C.A., Paz, D.A. J. Anat. (2000) [Pubmed]
  14. Sympathetic hyperreactivity in offspring of essential hypertensive patients. Nielsen, J.R., Gram, L.F., Fabricius, J., Harvald, B. Life Sci. (1984) [Pubmed]
  15. Adsorption of MTBE from contaminated water by carbonaceous resins and mordenite zeolite. Hung, H.W., Lin, T.F. J. Hazard. Mater. (2006) [Pubmed]
  16. Interferon production from peripheral blood, synovial fluid, and synovial tissue lymphocytes in patients with rheumatoid arthritis and ankylosing spondylitis. Chou, C.T., Lee, W., Chang, M.L., Lee, C.F., Kuo, S.Y., Lin, Y.M. J. Formos. Med. Assoc. (1990) [Pubmed]
  17. The precision of computer-generated surgical splints. Gateno, J., Xia, J., Teichgraeber, J.F., Rosen, A., Hultgren, B., Vadnais, T. J. Oral Maxillofac. Surg. (2003) [Pubmed]
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