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Gene Review

Rock1  -  Rho-associated coiled-coil containing...

Rattus norvegicus

Synonyms: Ac2-154, Liver regeneration-related protein LRRG199, P160Rock, ROCK-I, Rho-associated protein kinase 1, ...
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Disease relevance of Rock1


High impact information on Rock1

  • We identified the Y-27632 target as a Rho-associated protein kinase, p160ROCK [1].
  • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension [1].
  • In addition, Y-27632, an inhibitor of the Rho effector p160ROCK/Rho kinase, decreased thrombin-stimulated DNA synthesis and migration [4].
  • Deletion of Dab2 induces a urinary increase in specific plasma proteins such as vitamin D binding protein and retinol binding protein (Morris SM, Tallquist MD, Rock CO, and Cooper JA. EMBO J 21: 1555-1564, 2002) [5].
  • CONCLUSIONS: Our findings indicate that p160ROCK-mediated actin stress fiber assembly is involved in the pathophysiology of hepatic fibrogenesis and suggest that inhibitors of the RhoA-ROCK pathway might be useful therapeutically in liver fibrogenesis [6].

Chemical compound and disease context of Rock1


Biological context of Rock1

  • Transient cotransfection of 293T cells with expression plasmids for p160ROCK (Rho-associated coiled-coil-containing kinase) and v-Crk, but not SH2 or SH3 mutants of v-Crk, results in hyperactivation of p160ROCK [7].
  • A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth [6].

Anatomical context of Rock1


Associations of Rock1 with chemical compounds


Analytical, diagnostic and therapeutic context of Rock1

  • Therefore we investigated whether Y-27632, a p160ROCK-specific inhibitor, has beneficial effects on warm IR injury in an in vivo rat partial liver IR model and a rat orthotopic liver transplantation model [13].


  1. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., Narumiya, S. Nature (1997) [Pubmed]
  2. A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats. Tada, S., Iwamoto, H., Nakamuta, M., Sugimoto, R., Enjoji, M., Nakashima, Y., Nawata, H. J. Hepatol. (2001) [Pubmed]
  3. A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats. Takeda, K., Jin, M.B., Fujita, M., Fukai, M., Sakurai, T., Nakayama, M., Taniguchi, M., Suzuki, T., Shimamura, T., Furukawa, H., Todo, S. Surgery (2003) [Pubmed]
  4. Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Seasholtz, T.M., Majumdar, M., Kaplan, D.D., Brown, J.H. Circ. Res. (1999) [Pubmed]
  5. Mutually dependent localization of megalin and Dab2 in the renal proximal tubule. Nagai, J., Christensen, E.I., Morris, S.M., Willnow, T.E., Cooper, J.A., Nielsen, R. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  6. A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth. Iwamoto, H., Nakamuta, M., Tada, S., Sugimoto, R., Enjoji, M., Nawata, H. J. Hepatol. (2000) [Pubmed]
  7. Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein. Altun-Gultekin, Z.F., Chandriani, S., Bougeret, C., Ishizaki, T., Narumiya, S., de Graaf, P., Van Bergen en Henegouwen, P., Hanafusa, H., Wagner, J.A., Birge, R.B. Mol. Cell. Biol. (1998) [Pubmed]
  8. Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes. Avalos, A.M., Arthur, W.T., Schneider, P., Quest, A.F., Burridge, K., Leyton, L. J. Biol. Chem. (2004) [Pubmed]
  9. Rho kinase inhibition enhances axonal regeneration in the injured CNS. Fournier, A.E., Takizawa, B.T., Strittmatter, S.M. J. Neurosci. (2003) [Pubmed]
  10. The inositol trisphosphate pathway mediates platelet-activating-factor-induced pulmonary oedema. Göggel, R., Uhlig, S. Eur. Respir. J. (2005) [Pubmed]
  11. Role of Rho-associated protein kinase in tone and calcium sensitivity of cannulated rat mesenteric small arteries. VanBavel, E., van der Meulen, E.T., Spaan, J.A. Exp. Physiol. (2001) [Pubmed]
  12. High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells. Kawamura, H., Yokote, K., Asaumi, S., Kobayashi, K., Fujimoto, M., Maezawa, Y., Saito, Y., Mori, S. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  13. Prevention of ischemia-reperfusion-induced hepatic microcirculatory disruption by inhibiting stellate cell contraction using rock inhibitor. Mizunuma, K., Ohdan, H., Tashiro, H., Fudaba, Y., Ito, H., Asahara, T. Transplantation (2003) [Pubmed]
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