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Gene Review

Tnxb  -  tenascin XB

Mus musculus

Synonyms: TN-MHC, Tn-mhc, Tnx
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Disease relevance of Tnxb


High impact information on Tnxb

  • Studies of cultured dermal fibroblasts showed that although synthesis of collagen I by Tnxb-/- and wildtype cells was similar, Tnxb-/- fibroblasts failed to deposit collagen I into cell-associated matrix [1].
  • On Northern blots we detected a TN-X mRNA of approximately 13 kb in most tissues analyzed, whereas in various mouse cell lines mRNAs of approximately 11 and 13 kb were detected, suggesting the possibility of alternative splicing of TN-X transcripts [5].
  • The TN-X mRNA as well as the protein are predominantly expressed in heart and skeletal muscle, but the mRNA is found in most tissues at a low level [5].
  • Although the TN-X gene lies in the MHC class III locus, it is not expressed in the lymphoid organs analyzed, except for the staining around blood vessels [5].
  • The TN-X gene lies in the major histocompatibility complex (MHC) class III region, as it is the case for its human counterpart [5].

Biological context of Tnxb


Anatomical context of Tnxb

  • We raised antibodies against mouse TN-X fragments expressed in bacteria and used these antibodies to identify the TN-X protein in heart cell extracts and in the conditioned medium of a renal carcinoma cell line [5].
  • In skin and tissues of the digestive tract often a reciprocal distribution of TN-X and TN-C was observed [5].
  • TN-X was mainly localized in the perivascular stroma around tumor vessels, and weakly expressed in the intercellular spaces among tumor cells [2].
  • To determine whether TNX plays a part in tumour invasion and metastasis and to disclose its normal physiological role, we disrupted its gene in mouse embryonic stem cells by homologous recombination and created mice deficient in TNX [3].
  • TNX-positive cells then gradually spread all over the entire surface of the heart and invaded and formed primitive vascular channels in the myocardium [10].

Associations of Tnxb with chemical compounds


Regulatory relationships of Tnxb

  • In this study, we investigated the molecular mechanism by which TNX deficiency activates the MMP-2 gene [7].

Other interactions of Tnxb


Analytical, diagnostic and therapeutic context of Tnxb


  1. Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition. Mao, J.R., Taylor, G., Dean, W.B., Wagner, D.R., Afzal, V., Lotz, J.C., Rubin, E.M., Bristow, J. Nat. Genet. (2002) [Pubmed]
  2. Differential expression of tenascin-C and tenascin-X in human astrocytomas. Hasegawa, K., Yoshida, T., Matsumoto, K., Katsuta, K., Waga, S., Sakakura, T. Acta Neuropathol. (1997) [Pubmed]
  3. Tumour invasion and metastasis are promoted in mice deficient in tenascin-X. Matsumoto, K., Takayama, N., Ohnishi, J., Ohnishi, E., Shirayoshi, Y., Nakatsuji, N., Ariga, H. Genes Cells (2001) [Pubmed]
  4. Cell adhesion to tenascin-X mapping of cell adhesion sites and identification of integrin receptors. Elefteriou, F., Exposito, J.Y., Garrone, R., Lethias, C. Eur. J. Biochem. (1999) [Pubmed]
  5. The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C. Matsumoto, K., Saga, Y., Ikemura, T., Sakakura, T., Chiquet-Ehrismann, R. J. Cell Biol. (1994) [Pubmed]
  6. Structural analysis of mouse tenascin-X: evolutionary aspects of reduplication of FNIII repeats in the tenascin gene family. Ikuta, T., Sogawa, N., Ariga, H., Ikemura, T., Matsumoto, K. Gene (1998) [Pubmed]
  7. Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway. Matsumoto, K., Minamitani, T., Orba, Y., Sato, M., Sawa, H., Ariga, H. Exp. Cell Res. (2004) [Pubmed]
  8. Tenascin-X expression in tumor cells and fibroblasts: glucocorticoids as negative regulators in fibroblasts. Sakai, T., Furukawa, Y., Chiquet-Ehrismann, R., Nakamura, M., Kitagawa, S., Ikemura, T., Matsumoto, K. J. Cell. Sci. (1996) [Pubmed]
  9. Extracellular matrix tenascin-X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation. Ikuta, T., Ariga, H., Matsumoto, K. Genes Cells (2000) [Pubmed]
  10. The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse. Imanaka-Yoshida, K., Matsumoto, K., Hara, M., Sakakura, T., Yoshida, T. Differentiation (2003) [Pubmed]
  11. Deficiency of tenascin-X causes a decrease in the level of expression of type VI collagen. Minamitani, T., Ariga, H., Matsumoto, K. Exp. Cell Res. (2004) [Pubmed]
  12. Triglyceride accumulation and altered composition of triglyceride-associated fatty acids in the skin of tenascin-X-deficient mice. Matsumoto, K., Sato, T., Oka, S., Orba, Y., Sawa, H., Kabayama, K., Inokuchi, J., Ariga, H. Genes Cells (2004) [Pubmed]
  13. Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C. Matsumoto, K., Takahashi, K., Yoshiki, A., Kusakabe, M., Ariga, H. Jpn. J. Cancer Res. (2002) [Pubmed]
  14. Modulation of collagen fibrillogenesis by tenascin-X and type VI collagen. Minamitani, T., Ikuta, T., Saito, Y., Takebe, G., Sato, M., Sawa, H., Nishimura, T., Nakamura, F., Takahashi, K., Ariga, H., Matsumoto, K. Exp. Cell Res. (2004) [Pubmed]
  15. Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components. Zweers, M.C., Schalkwijk, J., van Kuppevelt, T.H., van Vlijmen-Willems, I.M., Bergers, M., Lethias, C., Lamme, E.N. Cell Tissue Res. (2005) [Pubmed]
  16. Dermal connective tissue development in mice: an essential role for tenascin-X. Egging, D.F., van Vlijmen, I., Starcher, B., Gijsen, Y., Zweers, M.C., Blankevoort, L., Bristow, J., Schalkwijk, J. Cell Tissue Res. (2006) [Pubmed]
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