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Gene Review

Tnc  -  tenascin C

Mus musculus

Synonyms: AI528729, C130033P17Rik, Hexabrachion, Hxb, TN, ...
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Disease relevance of Tnc


Psychiatry related information on Tnc

  • Anxiety was evaluated by the "social interaction test." Ten behavioral categories were recorded: body care, digging, nonsocial exploration, exploration from a distance, social investigation, threat, attack, avoidance/flee, defense/submission and immobility [6].
  • RESULTS: Ten days of prior stress exposure did not significantly alter the acquisition of limited-access alcohol drinking [7].

High impact information on Tnc


Chemical compound and disease context of Tnc


Biological context of Tnc


Anatomical context of Tnc


Associations of Tnc with chemical compounds


Physical interactions of Tnc

  • The c-Jun-induced transformation process involves complex regulation of tenascin-C expression [28].

Regulatory relationships of Tnc


Other interactions of Tnc


Analytical, diagnostic and therapeutic context of Tnc


  1. Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with transforming growth factor beta1. Kalembeyi, I., Inada, H., Nishiura, R., Imanaka-Yoshida, K., Sakakura, T., Yoshida, T. Int. J. Cancer (2003) [Pubmed]
  2. Differential expression of tenascin-C and tenascin-X in human astrocytomas. Hasegawa, K., Yoshida, T., Matsumoto, K., Katsuta, K., Waga, S., Sakakura, T. Acta Neuropathol. (1997) [Pubmed]
  3. Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C. Matsumoto, K., Takahashi, K., Yoshiki, A., Kusakabe, M., Ariga, H. Jpn. J. Cancer Res. (2002) [Pubmed]
  4. Cleft palate formation in fetal Br mice with midfacial retrusion: tenascin, fibronectin, laminin, and type IV collagen immunolocalization. Singh, G.D., Johnston, J., Ma, W., Lozanoff, S. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (1998) [Pubmed]
  5. Enhanced tenascin-C expression and matrix deposition during Ras/TGF-beta-induced progression of mammary tumor cells. Maschler, S., Grunert, S., Danielopol, A., Beug, H., Wirl, G. Oncogene (2004) [Pubmed]
  6. Anxiogenic-like activity of 3,4-methylenedioxy-methamphetamine ("Ecstasy") in the social interaction test is accompanied by an increase of c-fos expression in mice amygdala. Navarro, J.F., Rivera, A., Maldonado, E., Cavas, M., de la Calle, A. Prog. Neuropsychopharmacol. Biol. Psychiatry (2004) [Pubmed]
  7. Different effects of stress on alcohol drinking behaviour in male and female mice selectively bred for high alcohol preference. Chester, J.A., de Paula Barrenha, G., DeMaria, A., Finegan, A. Alcohol Alcohol. (2006) [Pubmed]
  8. Reversal of left-right asymmetry: a situs inversus mutation. Yokoyama, T., Copeland, N.G., Jenkins, N.A., Montgomery, C.A., Elder, F.F., Overbeek, P.A. Science (1993) [Pubmed]
  9. Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions. Erickson, H.P. Curr. Opin. Cell Biol. (1993) [Pubmed]
  10. Pax6 controls radial glia differentiation in the cerebral cortex. Götz, M., Stoykova, A., Gruss, P. Neuron (1998) [Pubmed]
  11. Tumors of female offspring of mice exposed prenatally to diethylstilbestrol. Walker, B.E. J. Natl. Cancer Inst. (1984) [Pubmed]
  12. Modulation of antigen trafficking to MHC class II-positive late endosomes of enterocytes. Zimmer, K.P., Büning, J., Weber, P., Kaiserlian, D., Strobel, S. Gastroenterology (2000) [Pubmed]
  13. Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice. El-Karef, A., Yoshida, T., Gabazza, E., Nishioka, T., Inada, H., Sakakura, T., Imanaka-Yoshida, K. J. Pathol. (2007) [Pubmed]
  14. Multiple promoter elements differentially regulate the expression of the mouse tenascin gene. Copertino, D.W., Edelman, G.M., Jones, F.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  15. Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse. Nakahara, H., Gabazza, E.C., Fujimoto, H., Nishii, Y., D'Alessandro-Gabazza, C.N., Bruno, N.E., Takagi, T., Hayashi, T., Maruyama, J., Maruyama, K., Imanaka-Yoshida, K., Suzuki, K., Yoshida, T., Adachi, Y., Taguchi, O. Eur. J. Immunol. (2006) [Pubmed]
  16. Opposite impacts of tenascin-C and tenascin-R deficiency in mice on the functional outcome of facial nerve repair. Guntinas-Lichius, O., Angelov, D.N., Morellini, F., Lenzen, M., Skouras, E., Schachner, M., Irintchev, A. Eur. J. Neurosci. (2005) [Pubmed]
  17. Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis. Hashimoto, M., Koda, M., Ino, H., Yoshinaga, K., Murata, A., Yamazaki, M., Kojima, K., Chiba, K., Mori, C., Moriya, H. Acta Neuropathol. (2005) [Pubmed]
  18. The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse. Imanaka-Yoshida, K., Matsumoto, K., Hara, M., Sakakura, T., Yoshida, T. Differentiation (2003) [Pubmed]
  19. Tenascin-C expression during wallerian degeneration in C57BL/Wlds mice: possible implications for axonal regeneration. Fruttiger, M., Schachner, M., Martini, R. J. Neurocytol. (1995) [Pubmed]
  20. Neural stem/progenitor cells express 20 tenascin C isoforms that are differentially regulated by pax6. von Holst, A., Egbers, U., Prochiantz, A., Faissner, A. J. Biol. Chem. (2007) [Pubmed]
  21. The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C. Matsumoto, K., Saga, Y., Ikemura, T., Sakakura, T., Chiquet-Ehrismann, R. J. Cell Biol. (1994) [Pubmed]
  22. Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Dunbar, M.E., Dann, P.R., Robinson, G.W., Hennighausen, L., Zhang, J.P., Wysolmerski, J.J. Development (1999) [Pubmed]
  23. Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5. Moscoso, L.M., Cremer, H., Sanes, J.R. J. Neurosci. (1998) [Pubmed]
  24. Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. Midwood, K.S., Valenick, L.V., Hsia, H.C., Schwarzbauer, J.E. Mol. Biol. Cell (2004) [Pubmed]
  25. Tenascins are associated with lipid rafts isolated from mouse brain. Kappler, J., Baader, S.L., Franken, S., Pesheva, P., Schilling, K., Rauch, U., Gieselmann, V. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  26. Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis. Denda, S., Reichardt, L.F., Müller, U. Mol. Biol. Cell (1998) [Pubmed]
  27. Tyrosine hydroxylase activity and its mRNA level in dopaminergic neurons of tenascin gene knockout mouse. Fukamauchi, F., Mataga, N., Wang, Y.J., Sato, S., Yoshiki, A., Kusakabe, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  28. The c-Jun-induced transformation process involves complex regulation of tenascin-C expression. Mettouchi, A., Cabon, F., Montreau, N., Dejong, V., Vernier, P., Gherzi, R., Mercier, G., Binétruy, B. Mol. Cell. Biol. (1997) [Pubmed]
  29. Tenascin-C deposition requires beta3 integrin and Src. Yang, Y., Dang, D., Mogi, S., Ramos, D.M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  30. FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration. McKean, D.M., Sisbarro, L., Ilic, D., Kaplan-Alburquerque, N., Nemenoff, R., Weiser-Evans, M., Kern, M.J., Jones, P.L. J. Cell Biol. (2003) [Pubmed]
  31. Corneal wound healing in tenascin knockout mouse. Matsuda, A., Yoshiki, A., Tagawa, Y., Matsuda, H., Kusakabe, M. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  32. Genetic mapping of the whirler mutation. Rogers, M.J., Fleming, J., Kiernan, B.W., Mburu, P., Varela, A., Brown, S.D., Steel, K.P. Mamm. Genome (1999) [Pubmed]
  33. Development of astrocytes in the mouse hippocampus as tracked by tenascin-C gene expression. Yuasa, S. Arch. Histol. Cytol. (2001) [Pubmed]
  34. Tenascin-C expression and splice variant in habu snake venom-induced glomerulonephritis. Matsumoto, K., Hiraiwa, N., Yoshiki, A., Ohnishi, M., Kusakabe, M. Exp. Mol. Pathol. (2002) [Pubmed]
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