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Gene Review

Ltbp1  -  latent transforming growth factor beta...

Rattus norvegicus

Synonyms: LTBP-1, Latent-transforming growth factor beta-binding protein 1, TGF-beta-1-BP-1, Transforming growth factor beta-1-binding protein 1, Transforming growth factor beta-1-masking protein large subunit
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Disease relevance of Ltbp1


High impact information on Ltbp1


Biological context of Ltbp1


Anatomical context of Ltbp1


Associations of Ltbp1 with chemical compounds

  • Using a cell enzyme-linked immunosorbent assay (ELISA), a differential increase of partly deoxycholate (DOC)-resistant, matrix-bound LTBP-1 and -2 was measured in cultured stellate cells [7].
  • Metabolic labeling of PC with [35S]-Met/Cys followed by immunoprecipitation of cell lysates with LTBP antiserum confirmed the synthesis of the high molecular mass complex of 250 kd containing LTBP with a molecular mass of 160 kd [11].
  • Although 24,25 induced the expression of LTBP1 by RCs, TGF-beta1 incorporation into the matrix is not regulated by this vitamin D3 metabolite [12].
  • These effects were associated with the prevention of macrophage glomerular infiltration, and the inhibition of the TGF-beta axes in foam cells as shown by the reduction in cytoplasm immunostaining for TGF-beta and LTBP-1; heparin also reduced peri-macrophagic collagen IV deposition [13].

Physical interactions of Ltbp1


Regulatory relationships of Ltbp1


Other interactions of Ltbp1

  • RESULTS: Induction of glomerular LTBP-1 mRNA was detected on day 2 of disease, while mRNA for fibrillin-1 was already upregulated 1 day after induction of disease [2].
  • During the transformation of HSC to myofibroblasts, LAP and LTBP become strongly colocalized with other components of the cytoskeletal network like smooth muscle--actin, desmin, and talin [10].
  • When the intensity of the immunoreactivity in the injured side was compared to that of the contralateral side, significantly increasing differences were found for TGF-beta 2 (p < 0.003) and LTBP (p < 0.002) [16].
  • Immunostainings of normal and fibrotic livers demonstrate intense signals for LTBP-1 and -2, preferably in parenchymal, but also nonparenchymal, cells and in fibrotic extracellular matrix [7].
  • We showed that TGF-beta ligand and receptor mRNA levels did not increase during the transition to adult-type repair in fetal skin, whereas LTBP-1 and fibromodulin expression decreased [17].

Analytical, diagnostic and therapeutic context of Ltbp1


  1. Latent transforming growth factor-beta binding protein-1, a component of latent transforming growth factor-beta complex, accelerates the migration of aortic smooth muscle cells in diabetic rats through integrin-beta3. Kanzaki, T., Otabe, M. Diabetes (2003) [Pubmed]
  2. Induction and coexpression of latent transforming growth factor beta-binding protein-1 and fibrillin-1 in experimental glomerulonephritis. Porst, M., Daniel, C., Plank, C., Schocklmann, H.O., Reinhardt, D.P., Hartner, A. Nephron Exp. Nephrol. (2006) [Pubmed]
  3. Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia. Zhu, Y., Culmsee, C., Roth-Eichhorn, S., Krieglstein, J. Neuroscience (2001) [Pubmed]
  4. Matrix-associated latent TGF-beta with latent TGF-beta binding protein in the progressive process in adriamycin-induced nephropathy. Tamaki, K., Okuda, S., Miyazono, K., Nakayama, M., Fujishima, M. Lab. Invest. (1995) [Pubmed]
  5. Isoforms and splice variant of transforming growth factor beta-binding protein in rat hepatic stellate cells. Gong, W., Roth, S., Michel, K., Gressner, A.M. Gastroenterology (1998) [Pubmed]
  6. Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. Dallas, S.L., Miyazono, K., Skerry, T.M., Mundy, G.R., Bonewald, L.F. J. Cell Biol. (1995) [Pubmed]
  7. Expression and matrix deposition of latent transforming growth factor beta binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture. Breitkopf, K., Lahme, B., Tag, C.G., Gressner, A.M. Hepatology (2001) [Pubmed]
  8. Localization of transforming growth factor-beta and latent transforming growth factor-beta binding protein in rat kidney. Ando, T., Okuda, S., Tamaki, K., Yoshitomi, K., Fujishima, M. Kidney Int. (1995) [Pubmed]
  9. Transforming growth factor-beta 1 in hypertensive renal injury in Dahl salt-sensitive rats. Tamaki, K., Okuda, S., Nakayama, M., Yanagida, T., Fujishima, M. J. Am. Soc. Nephrol. (1996) [Pubmed]
  10. Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells. Roth-Eichhorn, S., Kühl, K., Gressner, A.M. Hepatology (1998) [Pubmed]
  11. Expression and release of the latent transforming growth factor beta binding protein by hepatocytes from rat liver. Roth, S., Schurek, J., Gressner, A.M. Hepatology (1997) [Pubmed]
  12. Vitamin D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes. Pedrozo, H.A., Schwartz, Z., Mokeyev, T., Ornoy, A., Xin-Sheng, W., Bonewald, L.F., Dean, D.D., Boyan, B.D. J. Cell. Biochem. (1999) [Pubmed]
  13. Heparin reduces glomerular infiltration and TGF-beta protein expression by macrophages in puromycin glomerulosclerosis. Ceol, M., Vianello, D., Schleicher, E., Anglani, F., Barbanti, M., Bonfante, L., Bertaglia, G., Graziotto, R., D'Angelo, A., Del Prete, D., Gambaro, G. J. Nephrol. (2003) [Pubmed]
  14. TGF-beta 1 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy. Tamaki, K., Okuda, S., Ando, T., Iwamoto, T., Nakayama, M., Fujishima, M. Kidney Int. (1994) [Pubmed]
  15. Induction of transforming growth factor-beta during cardiac allograft rejection. Waltenberger, J., Wanders, A., Fellström, B., Miyazono, K., Heldin, C.H., Funa, K. J. Immunol. (1993) [Pubmed]
  16. Axotomy of rat facial nerve induces TGF-beta and latent TGF-beta binding protein. Colosetti, P., Olsson, T., Miyazono, K., Funa, K. Brain Res. Bull. (1995) [Pubmed]
  17. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Soo, C., Hu, F.Y., Zhang, X., Wang, Y., Beanes, S.R., Lorenz, H.P., Hedrick, M.H., Mackool, R.J., Plaas, A., Kim, S.J., Longaker, M.T., Freymiller, E., Ting, K. Am. J. Pathol. (2000) [Pubmed]
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