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Gene Review

Mif  -  macrophage migration inhibitory factor...

Rattus norvegicus

Synonyms: Glutathione-binding 13 kDa protein, L-dopachrome isomerase, L-dopachrome tautomerase, MIF, Macrophage migration inhibitory factor, ...
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Analytical, diagnostic and therapeutic context of Mif


  1. Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. Sakai, Y., Masamune, A., Satoh, A., Nishihira, J., Yamagiwa, T., Shimosegawa, T. Gastroenterology (2003) [Pubmed]
  2. Differential expression of cytokines in rat osteosarcoma and malignant fibrous histiocytoma cell lines induced by 4-(hydroxyamino)quinoline-1-oxide. Honoki, K., Tsujiuchi, T., Sasaki, Y., Tsutsumi, M., Morishita, T., Kido, A., Miyauchi, Y., Mii, Y., Takakura, Y., Konishi, Y. Mol. Carcinog. (2002) [Pubmed]
  3. De Novo renal expression of macrophage migration inhibitory factor during the development of rat crescentic glomerulonephritis. Lan, H.Y., Mu, W., Yang, N., Meinhardt, A., Nikolic-Paterson, D.J., Ng, Y.Y., Bacher, M., Atkins, R.C., Bucala, R. Am. J. Pathol. (1996) [Pubmed]
  4. Characterization of gene expression in resting and activated mast cells. Chen, H., Centola, M., Altschul, S.F., Metzger, H. J. Exp. Med. (1998) [Pubmed]
  5. Contribution of macrophage migration inhibitory factor to extracellular signal-regulated kinase activation by oxidative stress in cardiomyocytes. Fukuzawa, J., Nishihira, J., Hasebe, N., Haneda, T., Osaki, J., Saito, T., Nomura, T., Fujino, T., Wakamiya, N., Kikuchi, K. J. Biol. Chem. (2002) [Pubmed]
  6. Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis. Leech, M., Metz, C., Santos, L., Peng, T., Holdsworth, S.R., Bucala, R., Morand, E.F. Arthritis Rheum. (1998) [Pubmed]
  7. Spironolactone Prevents Diabetic Nephropathy through an Anti-Inflammatory Mechanism in Type 2 Diabetic Rats. Han, S.Y., Kim, C.H., Kim, H.S., Jee, Y.H., Song, H.K., Lee, M.H., Han, K.H., Kim, H.K., Kang, Y.S., Han, J.Y., Kim, Y.S., Cha, D.R. J. Am. Soc. Nephrol. (2006) [Pubmed]
  8. A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment. Meinhardt, A., Bacher, M., O'Bryan, M.K., McFarlane, J.R., Mallidis, C., Lehmann, C., Metz, C.N., de Kretser, D.M., Bucala, R., Hedger, M.P. J. Cell. Sci. (1999) [Pubmed]
  9. Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy. Kim, Y.G., Huang, X.R., Suga, S., Mazzali, M., Tang, D., Metz, C., Bucala, R., Kivlighn, S., Johnson, R.J., Lan, H.Y. Mol. Med. (2000) [Pubmed]
  10. Effects of macrophage migration inhibitory factor and macrophage migration stimulatory factor on function and survival of foetal dopaminergic grafts in the 6-hydroxydopamine rat model of Parkinson's disease. Schwarz, S.C., Schwarz, J., Sautter, J., Oertel, W.H. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1998) [Pubmed]
  11. Effects of IL-1beta, TNF-alpha, and macrophage migration inhibitory factor on prostacyclin synthesis in rat pulmonary artery smooth muscle cells. Itoh, A., Nishihira, J., Makita, H., Miyamoto, K., Yamaguchi, E., Nishimura, M. Respirology (2003) [Pubmed]
  12. Immunohistochemical study of macrophage migration inhibitory factor in rat liver fibrosis induced by thioacetamide. Hori, Y., Sato, S., Yamate, J., Kurasaki, M., Nishihira, J., Hosokawa, T., Fujita, H., Saito, T. European journal of histochemistry : EJH. (2003) [Pubmed]
  13. Adrenomedullin is both proinflammatory and antiinflammatory: its effects on gene expression and secretion of cytokines and macrophage migration inhibitory factor in NR8383 macrophage cell line. Wong, L.Y., Cheung, B.M., Li, Y.Y., Tang, F. Endocrinology (2005) [Pubmed]
  14. Influence of macrophage migration inhibitory factor (MIF) on the zinc content and redox state of protein-bound sulphydryl groups in rat sperm: indications for a new role of MIF in sperm maturation. Eickhoff, R., Baldauf, C., Koyro, H.W., Wennemuth, G., Suga, Y., Seitz, J., Henkel, R., Meinhardt, A. Mol. Hum. Reprod. (2004) [Pubmed]
  15. Increased expression of macrophage migration inhibitory factor during fracture healing in rats. Onodera, S., Nishihira, J., Yamazaki, M., Ishibashi, T., Minami, A. Histochem. Cell Biol. (2004) [Pubmed]
  16. Expression of macrophage migration inhibitory factor in rat skin during embryonic development. Shimizu, T., Ogata, A., Honda, A., Nishihira, J., Watanabe, H., Abe, R., Zhao, Y., Shimizu, H. Exp. Dermatol. (2005) [Pubmed]
  17. Changes in content of macrophage migration inhibitory factor secreted by Schwann cells after peripheral nerve injury. Huang, T., Qin, J.Q., Huo, X.K., Yu, L., Xiong, S.H., Liu, D.Y., Zhong, S.Z. Di Yi Jun Yi Da Xue Xue Bao (2002) [Pubmed]
  18. Macrophage migration inhibitory factor suppresses transforming growth factor-beta2 secretion in cultured rat testicular peritubular cells. Müller, R., Klug, J., Rodewald, M., Meinhardt, A. Reprod. Fertil. Dev. (2005) [Pubmed]
  19. Induction of MIF synthesis and secretion by tubular epithelial cells: a novel action of angiotensin II. Rice, E.K., Tesch, G.H., Cao, Z., Cooper, M.E., Metz, C.N., Bucala, R., Atkins, R.C., Nikolic-Paterson, D.J. Kidney Int. (2003) [Pubmed]
  20. Macrophage migration inhibitory factor: an intracellular inhibitor of angiotensin II-induced increases in neuronal activity. Sun, C., Li, H., Leng, L., Raizada, M.K., Bucala, R., Sumners, C. J. Neurosci. (2004) [Pubmed]
  21. Glutathione binding rat liver 13k protein is the homologue of the macrophage migration inhibitory factor. Sakai, M., Nishihira, J., Hibiya, Y., Koyama, Y., Nishi, S. Biochem. Mol. Biol. Int. (1994) [Pubmed]
  22. Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. Mandrup-Poulsen, T., Bendtzen, K., Nerup, J., Dinarello, C.A., Svenson, M., Nielsen, J.H. Diabetologia (1986) [Pubmed]
  23. Macrophage migration inhibitory factor is released from pituitary folliculo-stellate-like cells by endotoxin and dexamethasone and attenuates the steroid-induced inhibition of interleukin 6 release. Tierney, T., Patel, R., Stead, C.A., Leng, L., Bucala, R., Buckingham, J.C. Endocrinology (2005) [Pubmed]
  24. Regulatory cytokine expression and interstitial fluid formation in the normal and inflamed rat testis are under leydig cell control. Hedger, M., Klug, J., Fröhlich, S., Müller, R., Meinhardt, A. J. Androl. (2005) [Pubmed]
  25. The effects of spaceflight on mRNA levels for cytokines in proximal tibia of ovariectomized rats. Zhang, M., Turner, R.T. Aviation, space, and environmental medicine. (1998) [Pubmed]
  26. Crystallization of rat liver macrophage migration inhibitory factor for MAD analysis. Sugimoto, H., Suzuki, M., Nakagawa, A., Tanaka, I., Fujinaga, M., Nishihira, J. J. Struct. Biol. (1995) [Pubmed]
  27. Identification of macrophage migration inhibitory factor mRNA expression in neural cells of the rat brain by in situ hybridization. Ogata, A., Nishihira, J., Suzuki, T., Nagashima, K., Tashiro, K. Neurosci. Lett. (1998) [Pubmed]
  28. Up-regulation of macrophage migration inhibitory factor in acute renal allograft rejection in the rat. Brown, F.G., Nikolic-Paterson, D.J., Metz, C., Bucala, R., Atkins, R.C., Lan, H.Y. Clin. Exp. Immunol. (1999) [Pubmed]
  29. Induction of macrophage migration inhibitory factor messenger ribonucleic acid in rat forebrain by reperfusion. Yoshimoto, T., Nishihira, J., Tada, M., Houkin, K., Abe, H. Neurosurgery (1997) [Pubmed]
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