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Gene Review

APOL1  -  apolipoprotein L, 1

Homo sapiens

Synonyms: APO-L, APOL, APOL-I, Apo-L, ApoL, ...
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Disease relevance of APOL1


High impact information on APOL1


Biological context of APOL1


Anatomical context of APOL1


Associations of APOL1 with chemical compounds

  • Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects [1].
  • ApoLp-III-W@130 displayed a lambda(max) of 338 nm while interaction with DMPC resulted in a blue shift to 331 nm [15].
  • ApoLp-I was delipidated with ethanol/ether and solubilized in buffer that contained radioactive lysophosphatidylcholine ([3H]LPC) above the critical micellar concentration [16].
  • ApoLP-C-III-B showed conformational changes in the circular dichroic spectrum and a shift in the intrinsic tryptophan fluorescence spectrum [17].
  • ApoLp A-I has been recombined in almost quantitative yield in the presence of lysolecithin with phosphatidylcholine and sphingomyelin to particles of reproducible stoichiometry [18].

Other interactions of APOL1


Analytical, diagnostic and therapeutic context of APOL1


  1. Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects. Duchateau, P.N., Movsesyan, I., Yamashita, S., Sakai, N., Hirano, K., Schoenhaus, S.A., O'Connor-Kearns, P.M., Spencer, S.J., Jaffe, R.B., Redberg, R.F., Ishida, B.Y., Matsuzawa, Y., Kane, J.P., Malloy, M.J. J. Lipid Res. (2000) [Pubmed]
  2. Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL. Albert, T.S., Duchateau, P.N., Deeb, S.S., Pullinger, C.R., Cho, M.H., Heilbron, D.C., Malloy, M.J., Kane, J.P., Brown, B.G. J. Lipid Res. (2005) [Pubmed]
  3. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Genovese, G., Friedman, D.J., Ross, M.D., Lecordier, L., Uzureau, P., Freedman, B.I., Bowden, D.W., Langefeld, C.D., Oleksyk, T.K., Uscinski Knob, A.L., Bernhardy, A.J., Hicks, P.J., Nelson, G.W., Vanhollebeke, B., Winkler, C.A., Kopp, J.B., Pays, E., Pollak, M.R. Science. (2010) [Pubmed]
  4. Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. Tzur, S., Rosset, S., Shemer, R., Yudkovsky, G., Selig, S., Tarekegn, A., Bekele, E., Bradman, N., Wasser, W.G., Behar, D.M., Skorecki, K. Hum. Genet. (2010) [Pubmed]
  5. Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. Mimmack, M.L., Ryan, M., Baba, H., Navarro-Ruiz, J., Iritani, S., Faull, R.L., McKenna, P.J., Jones, P.B., Arai, H., Starkey, M., Emson, P.C., Bahn, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. Nielsen, M.J., Petersen, S.V., Jacobsen, C., Oxvig, C., Rees, D., M??ller, H.J., Moestrup, S.K. Blood (2006) [Pubmed]
  7. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. Horrevoets, A.J., Fontijn, R.D., van Zonneveld, A.J., de Vries, C.J., ten Cate, J.W., Pannekoek, H. Blood (1999) [Pubmed]
  8. Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L. Duchateau, P.N., Pullinger, C.R., Orellana, R.E., Kunitake, S.T., Naya-Vigne, J., O'Connor, P.M., Malloy, M.J., Kane, J.P. J. Biol. Chem. (1997) [Pubmed]
  9. Letter: Synthesis of a protein with the properties of the apolipoprotein C-I (ApoLP-Ser). Harding, D.R., Battersby, J.E., Husbands, D.R., Hancock, W.S. J. Am. Chem. Soc. (1976) [Pubmed]
  10. The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. Monajemi, H., Fontijn, R.D., Pannekoek, H., Horrevoets, A.J. Genomics (2002) [Pubmed]
  11. Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. McGhee, K.A., Morris, D.W., Schwaiger, S., Nangle, J.M., Donohoe, G., Clarke, S., Meagher, D., Quinn, J., Scully, P., Waddington, J.L., Gill, M., Corvin, A. Schizophr. Res. (2005) [Pubmed]
  12. Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I. Vanhollebeke, B., Truc, P., Poelvoorde, P., Pays, A., Joshi, P.P., Katti, R., Jannin, J.G., Pays, E. N. Engl. J. Med. (2006) [Pubmed]
  13. Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. Pérez-Morga, D., Vanhollebeke, B., Paturiaux-Hanocq, F., Nolan, D.P., Lins, L., Homblé, F., Vanhamme, L., Tebabi, P., Pays, A., Poelvoorde, P., Jacquet, A., Brasseur, R., Pays, E. Science (2005) [Pubmed]
  14. Analysis of blood plasma proteins in patients with Alzheimer's disease by two-dimensional electrophoresis, sequence homology and immunodetection. Ueno, I., Sakai, T., Yamaoka, M., Yoshida, R., Tsugita, A. Electrophoresis (2000) [Pubmed]
  15. Lipid binding of the exchangeable apolipoprotein apolipophorin III induces major changes in fluorescence properties of tryptophans 115 and 130. Weers, P.M., Prenner, E.J., Kay, C., Ryan, R.O. Biochemistry (2000) [Pubmed]
  16. A strategy for solubilizing delipidated apolipoprotein with lysophosphatidylcholine and reconstitution with phosphatidylcholine. Kawooya, J.K., Wells, M.A., Law, J.H. Biochemistry (1989) [Pubmed]
  17. Lipid binding by fragments of apolipoprotein C-III-1 obtained by thrombin cleavage. Sparrow, J.T., Pownall, H.J., Hsu, F.J., Blumenthal, L.D., Culwell, A.R., Gotto, A.M. Biochemistry (1977) [Pubmed]
  18. Human high denisty apolipoprotein A-I-lysolecithin-lecithin and sphingomyelin complexes. A method for high yield recombinations to lipoprotein complexes of reproducible stoichiometry. Stoffel, W., Därr, W. Hoppe-Seyler's Z. Physiol. Chem. (1976) [Pubmed]
  19. In vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei. Faulkner, S.D., Oli, M.W., Kieft, R., Cotlin, L., Widener, J., Shiflett, A., Cipriano, M.J., Pacocha, S.E., Birkeland, S.R., Hajduk, S.L., McArthur, A.G. Eukaryotic Cell (2006) [Pubmed]
  20. The variant surface glycoprotein as a tool for adaptation in African trypanosomes. Pays, E. Microbes Infect. (2006) [Pubmed]
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