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Gene Review

BOC  -  BOC cell adhesion associated, oncogene...

Homo sapiens

Synonyms: Brother of CDO, CDON2, Protein BOC, UNQ604/PRO1190
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Disease relevance of BOC


High impact information on BOC

  • Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response [3].
  • Like CDO, BOC accelerates differentiation of cultured myoblast cell lines and participates in a positive feedback loop with the myogenic transcription factor, MyoD [4].
  • CDO and BOC are proposed to be components of a receptor complex that mediates some of the cell-cell interactions between muscle precursors that are required for myogenesis [4].
  • In contrast, FMLP (10 to 100 microM) stimulated the release of TXB2 from guinea pig eosinophils that was selectively inhibited by pretreatment of the cells with BOC-FMLP [5].
  • Solid-phase synthesis of 1-substituted tetrahydroisoquinoline derivatives employing BOC-protected tetrahydroisoquinoline carboxylic acids [6].

Biological context of BOC

  • Ester hydrolysis afforded the BOC-protected tetrahydroisoquinoline carboxylic acid scaffolds, which were then attached to (4-hydroxyphenyl)sulfide resin (Marshall linker) as the corresponding ester [6].
  • Removal of the BOC protecting group with trifluoroacetic acid followed by acylation gave solid-supported hydroxyproline derivatives [7].
  • A diastereoselective approach to the synthesis of 4-trifluoromethylated 2-alkyl- and 2,3-dialkylazetidines, including BOC-protected 4-trifluoromethylazetidin-2-ylcarboxylic acid, was developed via Wittig reaction of 4-trifluomethylated beta-lactam followed by alkylation and hydrogenation [8].
  • The study confirms a high prevalence of coliac disease in patients with BOC, but the relationship between these two pathologies still needs to be clarified [9].
  • Cyclization of (4-nitrobenzyl)-ethylenediamine with appropriate BOC-protected amino disuccinimido esters in dioxane at 90 degrees C resulted in the formation of 12- and 14-membered ring diamides in 40% and 44% yield, respectively [10].

Anatomical context of BOC

  • These include: the community factor, embryonic fibroblast growth factor (eFGF); classical cadherins, which mediate both adhesion and signaling; and cadherin-associated immunoglobulin superfamily members such as CDO, BOC and neogenin [11].
  • These observations are consistent with the notion that CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage [1].
  • In BOC shocks were delivered between the same oesophageal electrode and two chest pads joined with each other, positioned on both sides of the sternum [2].

Associations of BOC with chemical compounds

  • Compounds containing the tetrahydroisoquinoline ring system were prepared using solid-supported ester derivatives on a nucleophile-sensitive resin, starting from the corresponding BOC-protected amino acids [6].
  • After the resulting amino esters were converted to the BOC derivatives, the phenolic hydroxyl groups were alkylated with a series of alkyl halides to afford the corresponding ethers [6].
  • PURPOSE: We performed a randomized, placebo controlled double-blind trial to evaluate the effectiveness of Entonox (BOC Gases, Manchester, United Kingdom), that is 50% nitrous oxide and oxygen, as analgesia during transrectal ultrasound guided prostate biopsy [12].
  • The conformational analysis of four glutamic acid analogues containing a cyclopentyl or cyclohexyl ring, substituted in position 1 by a BOC protected amino group and a methyl ester group and in position 3 by a free carboxylate group, has been carried out in an aqueous environment, by 1H and 13C NMR spectroscopy, and molecular dynamics (MD) [13].
  • When the same protocol is applied to BOC-protected phenylalanine methyl ester, epimerization occurs so that the use of a more reactive aryl ester is required [14].

Other interactions of BOC

  • AHA and/or BOC-MLP decreased IL-8 production at 2-4 h after stimulation [15].
  • Twenty patients affected by bilateral occipital cortical-subcortical calcification (BOC) are described, 19 (95%) had epilepsy [9].
  • The compatibility of the imidazolium unit was demonstrated with DIC or DCC coupling reactions of protected amino acids and with classical cleavage of BOC or Fmoc protecting groups [16].
  • For the solution pathway the linear dipeptides were synthesized by coupling of the BOC-protected L-alpha-amino acid with the beta2-amino acid ester (EDC/HOBT) [17].

Analytical, diagnostic and therapeutic context of BOC

  • For example, the quantitation errors, based on a single external standard, for a series of steroids, hydantoins, and BOC- and Fmoc-protected amino acids by normal-phase HPLC with evaporative light-scattering detection average approximately +/-10% [18].
  • The aim of the study was to compare the bidirectional transoesophageal DC cardioversion (BOC) with unidirectional transoesophageal DC cardioversion (UOC) and to evaluate, if the reversion of the polarity of electrodes alters the effectiveness and the amount of energy during BOC [2].
  • After acetohydroxamic acid (AHA) and/or N-tert-butoxycarbonyl-methionyl-leucyl-phenylalanine (BOC-MLP) was added to H. pylori culture supernatant, IL-8 ELISA was analyzed for 9 h [15].


  1. Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. Wegorzewska, M., Krauss, R.S., Kang, J.S. Mol. Carcinog. (2003) [Pubmed]
  2. Does the change of the polarity of electrodes influence the results of transoesophageal bidirectional DC cardioversion? Poleszak, K., Kutarski, A., Koziara, D., Baszak, J., Oleszczak, K. Pacing and clinical electrophysiology : PACE. (1998) [Pubmed]
  3. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Yao, S., Lum, L., Beachy, P. Cell (2006) [Pubmed]
  4. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. Kang, J.S., Mulieri, P.J., Hu, Y., Taliana, L., Krauss, R.S. EMBO J. (2002) [Pubmed]
  5. Characterization of eosinophil cell activation by peptides. Differential effects of substance P, melittin, and FMET-Leu-Phe. Kroegel, C., Giembycz, M.A., Barnes, P.J. J. Immunol. (1990) [Pubmed]
  6. Solid-phase synthesis of 1-substituted tetrahydroisoquinoline derivatives employing BOC-protected tetrahydroisoquinoline carboxylic acids. Bunin, B.A., Dener, J.M., Kelly, D.E., Paras, N.A., Tario, J.D., Tushup, S.P. Journal of combinatorial chemistry. (2004) [Pubmed]
  7. Solid-phase library synthesis of alkoxyprolines. Boldi, A.M., Dener, J.M., Hopkins, T.P. Journal of combinatorial chemistry. (2001) [Pubmed]
  8. Synthesis of 4-trifluoromethylated 2-alkyl- and 2,3-dialkyl-substituted azetidines. Jiang, J., Shah, H., DeVita, R.J. Org. Lett. (2003) [Pubmed]
  9. Bilateral occipital calcification, epilepsy and coeliac disease: clinical and neuroimaging features of a new syndrome. Magaudda, A., Dalla Bernardina, B., De Marco, P., Sfaello, Z., Longo, M., Colamaria, V., Daniele, O., Tortorella, G., Tata, M.A., Di Perri, R. J. Neurol. Neurosurg. Psychiatr. (1993) [Pubmed]
  10. Convenient synthesis of bifunctional tetraaza macrocycles. McMurry, T.J., Brechbiel, M., Kumar, K., Gansow, O.A. Bioconjug. Chem. (1992) [Pubmed]
  11. Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact. Krauss, R.S., Cole, F., Gaio, U., Takaesu, G., Zhang, W., Kang, J.S. J. Cell. Sci. (2005) [Pubmed]
  12. Nitrous oxide (Entonox) inhalation and tolerance of transrectal ultrasound guided prostate biopsy: a double-blind randomized controlled study. Masood, J., Shah, N., Lane, T., Andrews, H., Simpson, P., Barua, J.M. J. Urol. (2002) [Pubmed]
  13. Conformational study in water by NMR and molecular modeling of cyclic glutamic acid analogues as probes of vitamin K dependent carboxylase. Larue, V., Gharbi-Benarous, J., Archer, F., Azerad, R., Girault, J.P. Journal of chemical information and computer sciences. (1996) [Pubmed]
  14. One-carbon chain extension of esters to alpha-chloroketones: a safer route without diazomethane. Wang, D., Schwinden, M.D., Radesca, L., Patel, B., Kronenthal, D., Huang, M.H., Nugent, W.A. J. Org. Chem. (2004) [Pubmed]
  15. Interleukin-8 expression by human neutrophils activated by Helicobacter pylori soluble proteins. Kim, J.S., Jung, H.C., Kim, J.M., Song, I.S., Kim, C.Y. Scand. J. Gastroenterol. (1998) [Pubmed]
  16. Functionalized ionic liquids as new supports for peptide coupling and traceless catalyzed carbon-carbon coupling reactions. Bonnette, F., Mincheva, Z., Lavastre, O. Comb. Chem. High Throughput Screen. (2006) [Pubmed]
  17. Synthesis and conformational investigation of cyclic dipeptides: 7-membered rings containing alpha- and beta-amino acids. Müller-Hartwieg, J.C., Akyel, K.G., Zimmermann, J. J. Pept. Sci. (2003) [Pubmed]
  18. Quantitation of combinatorial libraries of small organic molecules by normal-phase HPLC with evaporative light-scattering detection. Kibbey, C.E. Mol. Divers. (1996) [Pubmed]
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