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Chemical Compound Review

Lithostat     N-hydroxyethanamide

Synonyms: Prestwick_38, CHEMBL734, Lithostat (TN), zlchem 200, sJX`HLdmMAH`, ...
 
 
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Disease relevance of N-hydroxyethanamide

 

High impact information on N-hydroxyethanamide

 

Chemical compound and disease context of N-hydroxyethanamide

 

Biological context of N-hydroxyethanamide

  • However, the addition of acetohydroxamic acid (200 mg/liter), a potent urease inhibitor which inhibits ammonia production, did not completely restore cell growth, suggesting the difficulty of neutralizing the ammonia in the vicinity of the cells [11].
  • Viabilities of cells exposed to H. pylori for 2, 24, and 48 h, assessed by incorporation of neutral red dye, were 60, 27, and 16%, respectively; however, the viabilities of cells exposed to both H. pylori and acetohydroxamic acid were 92, 46, and 20% after 2, 24, and 48 h, respectively, (P less than 0.001) [12].
  • The effect of antibiotics and acetohydroxamic acid on bacterial hydrolysis of urea [13].
  • Adjustment of the parameters used by DOCK, in order to account for the presence of the metal ion in the active site, resulted in the calculation of best energy structures for the nickel-bound inhibitors beta-mercaptoethanol, acetohydroxamic acid, and diamidophosphoric acid [14].
  • Kinetics and mechanism of iron(III)-nitrilotriacetate complex reactions with phosphate and acetohydroxamic acid [15].
 

Anatomical context of N-hydroxyethanamide

 

Associations of N-hydroxyethanamide with other chemical compounds

 

Gene context of N-hydroxyethanamide

 

Analytical, diagnostic and therapeutic context of N-hydroxyethanamide

References

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  2. Inhibition of Helicobacter pylori by acetohydroxamic acid. Veldhuyzen van Zanten, S.J., Goldie, J., Hunt, R.H. Lancet (1990) [Pubmed]
  3. The exchange of Fe3+ between acetohydroxamic acid and transferrin. Spectrophotometric evidence for a mixed ligand complex. Cowart, R.E., Kojima, N., Bates, G.W. J. Biol. Chem. (1982) [Pubmed]
  4. Effect of inhibition of Helicobacter pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects. el Nujumi, A.M., Dorrian, C.A., Chittajallu, R.S., Neithercut, W.D., McColl, K.E. Gut (1991) [Pubmed]
  5. Inhibition of Jack Bean urease (EC 3.5.1.5) by acetohydroxamic acid and by phosphoramidate. An equivalent weight for urease. Dixon, N.E., Gazzola, C., Watters, J.J., Blakely, R.L., Zerner, B. J. Am. Chem. Soc. (1975) [Pubmed]
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  7. Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment. Nakamura, H., Yoshiyama, H., Takeuchi, H., Mizote, T., Okita, K., Nakazawa, T. Infect. Immun. (1998) [Pubmed]
  8. Receptor-mediated targeting of lipobeads bearing acetohydroxamic acid for eradication of Helicobacter pylori. Umamaheshwari, R.B., Jain, N.K. Journal of controlled release : official journal of the Controlled Release Society. (2004) [Pubmed]
  9. Urease activity in microbiologically-induced calcite precipitation. Bachmeier, K.L., Williams, A.E., Warmington, J.R., Bang, S.S. J. Biotechnol. (2002) [Pubmed]
  10. Matrix metalloproteinase inhibitors reduce phorbol ester-induced cutaneous inflammation and hyperplasia. Holleran, W.M., Galardy, R.E., Gao, W.N., Levy, D., Tang, P.C., Elias, P.M. Arch. Dermatol. Res. (1997) [Pubmed]
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  12. Helicobacter pylori urease activity is toxic to human gastric epithelial cells. Smoot, D.T., Mobley, H.L., Chippendale, G.R., Lewison, J.F., Resau, J.H. Infect. Immun. (1990) [Pubmed]
  13. The effect of antibiotics and acetohydroxamic acid on bacterial hydrolysis of urea. Vince, A.J., Chadwick, V.S. J. Antimicrob. Chemother. (1978) [Pubmed]
  14. Structure-based computational study of the catalytic and inhibition mechanisms of urease. Musiani, F., Arnofi, E., Casadio, R., Ciurli, S. J. Biol. Inorg. Chem. (2001) [Pubmed]
  15. Kinetics and mechanism of iron(III)-nitrilotriacetate complex reactions with phosphate and acetohydroxamic acid. Gabricević, M., Crumbliss, A.L. Inorganic chemistry. (2003) [Pubmed]
  16. Further observations on the potentiation of the antibacterial effect of methenamine by acetohydroxamic acid. Musher, D.M., Griffith, D.P., Templeton, G.B. J. Infect. Dis. (1976) [Pubmed]
  17. A randomized trial of acetohydroxamic acid for the treatment and prevention of infection-induced urinary stones in spinal cord injury patients. Griffith, D.P., Khonsari, F., Skurnick, J.H., James, K.E. J. Urol. (1988) [Pubmed]
  18. DNA repair synthesis induced by N-hydroxyurea, acetohydroxamic acid, and N-hydroxyurethane in primary rat hepatocyte cultures: comparative evaluation using the autoradiographic and the bromodeoxyuridine density-shift method. Rossberger, S., Andrae, U. Mutat. Res. (1985) [Pubmed]
  19. Floating microspheres bearing acetohydroxamic acid for the treatment of Helicobacter pylori. Umamaheshwari, R.B., Jain, S., Bhadra, D., Jain, N.K. J. Pharm. Pharmacol. (2003) [Pubmed]
  20. Cloning of urease gene sequences from Providencia stuartii. Mobley, H.L., Jones, B.D., Jerse, A.E. Infect. Immun. (1986) [Pubmed]
  21. Neutral acetohydroxamic acid coordination to a mononuclear Ni(II) center stabilized by an intramolecular hydrogen-bonding interaction. Rudzka, K., Makowska-Grzyska, M.M., Szajna, E., Arif, A.M., Berreau, L.M. Chem. Commun. (Camb.) (2005) [Pubmed]
  22. The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. Hamid-Bloomfield, S., Payne, A.N., Petrovic, A.A., Whittle, B.J. Br. J. Pharmacol. (1990) [Pubmed]
  23. Hard and soft X-ray absorption spectroscopic investigation of aqueous Fe(III)-hydroxamate siderophore complexes. Edwards, D.C., Myneni, S.C. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  24. Interleukin-8 expression by human neutrophils activated by Helicobacter pylori soluble proteins. Kim, J.S., Jung, H.C., Kim, J.M., Song, I.S., Kim, C.Y. Scand. J. Gastroenterol. (1998) [Pubmed]
  25. Synthesis of bicyclic molecular scaffolds (BTAa): An investigation towards new selective MMP-12 inhibitors. Mannino, C., Nievo, M., Machetti, F., Papakyriakou, A., Calderone, V., Fragai, M., Guarna, A. Bioorg. Med. Chem. (2006) [Pubmed]
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  29. Ureaplasma urealyticum-induced crystallization of magnesium ammonium phosphate and calcium phosphates in synthetic urine. Grenabo, L., Brorson, J.E., Hedelin, H., Pettersson, S. J. Urol. (1984) [Pubmed]
  30. Partial dissolution of struvite calculus with oral acetohydroxamic acid. Rodman, J.S., Williams, J.J., Peterson, C.M. Urology (1983) [Pubmed]
  31. In vitro inhibition of Helicobacter pylori urease: biochemical and ultrastructural analysis. Nilius, M., Bode, G., Lehnhardt, G., Malfertheiner, P. Eur. J. Clin. Invest. (1991) [Pubmed]
 
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