Gene Review:
Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N...
Rattus norvegicus
Synonyms:
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, Glcne, UDP-GlcNAc-2-epimerase/ManAc kinase
- NGF stimulates incorporation of fucose or glucosamine into an external glycoprotein in cultured rat PC12 pheochromocytoma cells. McGuire, J.C., Greene, L.A., Furano, A.V. Cell (1978)
- Role of the glucosamine pathway in fat-induced insulin resistance. Hawkins, M., Barzilai, N., Liu, R., Hu, M., Chen, W., Rossetti, L. J. Clin. Invest. (1997)
- Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity. Baron, A.D., Zhu, J.S., Zhu, J.H., Weldon, H., Maianu, L., Garvey, W.T. J. Clin. Invest. (1995)
- Glucosamine in osteoarthritis. Russell, A.I., McCarty, M.F. Lancet (1999)
- Structure and properties of an under-sulfated heparan sulfate proteoglycan synthesized by a rat hepatoma cell line. Robinson, J., Viti, M., Höök, M. J. Cell Biol. (1984)
- Differential mechanisms of feeding modulation induced by amino sugars in rats. Okabe, Y., Sakata, T., Fujimoto, K., Kurata, K., Yoshimatsu, H., Ueda, K. Proc. Soc. Exp. Biol. Med. (1988)
- A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Wang, J., Liu, R., Hawkins, M., Barzilai, N., Rossetti, L. Nature (1998)
- In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. Rossetti, L., Hawkins, M., Chen, W., Gindi, J., Barzilai, N. J. Clin. Invest. (1995)
- Mechanism of expression of Thomsen-Friedenreich (T) antigen at the cell surface of a mammary adenocarcinoma. Hull, S.R., Carraway, K.L. FASEB J. (1988)
- Biosynthesis of a nonphysiological sialic acid in different rat organs, using N-propanoyl-D-hexosamines as precursors. Kayser, H., Zeitler, R., Kannicht, C., Grunow, D., Nuck, R., Reutter, W. J. Biol. Chem. (1992)
- Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy. Pang, Y., Bounelis, P., Chatham, J.C., Marchase, R.B. Diabetes (2004)
- Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. Barzilai, N., Hawkins, M., Angelov, I., Hu, M., Rossetti, L. Diabetes (1996)
- Differential regulation of thyrotropin subunit apoprotein and carbohydrate biosynthesis by thyroid hormone. Taylor, T., Weintraub, B.D. Endocrinology (1985)
- Lec3 Chinese hamster ovary mutants lack UDP-N-acetylglucosamine 2-epimerase activity because of mutations in the epimerase domain of the Gne gene. Hong, Y., Stanley, P. J. Biol. Chem. (2003)
- Inhibition of glycolysis and interference with protein synthesis in hepatoma cells. Ferrero, M.E., Ferrero, E., Bernelli-Zazzera, A. J. Natl. Cancer Inst. (1977)
- Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death. Liu, K., Paterson, A.J., Chin, E., Kudlow, J.E. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility. Han, I., Kudlow, J.E. Mol. Cell. Biol. (1997)
- Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells. McClain, D.A., Paterson, A.J., Roos, M.D., Wei, X., Kudlow, J.E. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Role of hexosamine biosynthesis in glucose-mediated up-regulation of lipogenic enzyme mRNA levels: effects of glucose, glutamine, and glucosamine on glycerophosphate dehydrogenase, fatty acid synthase, and acetyl-CoA carboxylase mRNA levels. Rumberger, J.M., Wu, T., Hering, M.A., Marshall, S. J. Biol. Chem. (2003)
- Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes. Gouze, J.N., Bordji, K., Gulberti, S., Terlain, B., Netter, P., Magdalou, J., Fournel-Gigleux, S., Ouzzine, M. Arthritis Rheum. (2001)
- Galactosamine-induced cell death in primary cultures of rat hepatocytes. Schanne, F.A., Pfau, R.G., Farber, J.L. Am. J. Pathol. (1980)
- Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells. Goldberg, H.J., Scholey, J., Fantus, I.G. Diabetes (2000)
- A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase. Stäsche, R., Hinderlich, S., Weise, C., Effertz, K., Lucka, L., Moormann, P., Reutter, W. J. Biol. Chem. (1997)
- Purification and characterization of a major human Pneumocystis carinii surface antigen. Lundgren, B., Lipschik, G.Y., Kovacs, J.A. J. Clin. Invest. (1991)
- In vivo inflammatory stimulation induces a transient change in the binding of thrombin to rat peritoneal macrophages. Fisker, S., Kudahl, K., Sonne, O. Exp. Cell Res. (1992)
- Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway. Gouze, J.N., Bianchi, A., Bécuwe, P., Dauça, M., Netter, P., Magdalou, J., Terlain, B., Bordji, K. FEBS Lett. (2002)
- Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase. Hashimoto, Y., Orellana, A., Gil, G., Hirschberg, C.B. J. Biol. Chem. (1992)
- Phosphorylation of D-glucosamine by rat liver glucokinase. Oguchi, M., Miyatake, Y., Ayabe, J., Akamatsu, N. J. Biochem. (1975)
- Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via phosphatidylinositol 3-kinase pathway in rat aortic smooth muscle cells. Sato, A., Sasaoka, T., Yamazaki, K., Nakamura, N., Temaru, R., Ishiki, M., Takata, M., Kishida, M., Wada, T., Ishihara, H., Usui, I., Urakaze, M., Kobayashi, M. Atherosclerosis (2001)
- High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells. Kawamura, H., Yokote, K., Asaumi, S., Kobayashi, K., Fujimoto, M., Maezawa, Y., Saito, Y., Mori, S. Arterioscler. Thromb. Vasc. Biol. (2004)
- Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine: fructose-6-phosphate amidotransferase in rat-1 fibroblasts. Crook, E.D., Daniels, M.C., Smith, T.M., McClain, D.A. Diabetes (1993)
- Glucosamine-induced insulin resistance in L6 muscle cells. Bailey, C.J., Turner, S.L. Diabetes, obesity & metabolism. (2004)
- Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation. Spampinato, D., Giaccari, A., Trischitta, V., Costanzo, B.V., Morviducci, L., Buongiorno, A., Di Mario, U., Vigneri, R., Frittitta, L. Metab. Clin. Exp. (2003)
- The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta. Goldberg, H.J., Whiteside, C.I., Fantus, I.G. J. Biol. Chem. (2002)
- Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. Kim, Y.B., Zhu, J.S., Zierath, J.R., Shen, H.Q., Baron, A.D., Kahn, B.B. Diabetes (1999)
- Effects of chronic ethanol administration on hepatic glycoprotein secretion in the rat. Sorrell, M.F., Nauss, J.M., Donohue, T.M., Tuma, D.J. Gastroenterology (1983)
- Glucosamine 6-phosphate synthase of regenerating rat liver. Miyagi, T., Tsuiki, S. Cancer Res. (1979)
- Exercise-stimulated glucose turnover in the rat is impaired by glucosamine infusion. Miles, P.D., Higo, K., Olefsky, J.M. Diabetes (2001)
- Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly. Federici, M., Giaccari, A., Hribal, M.L., Giovannone, B., Lauro, D., Morviducci, L., Pastore, L., Tamburrano, G., Lauro, R., Sesti, G. Diabetes (1999)