Disease relevance of IQCB1

• Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers [1].
• Children and adolescents with Klinefelter syndrome (XXY) have been reported to show deficits in language processing including VIQ < PIQ and a learning disability in reading and spelling [2].
• Low PIQ correlated with the presence of macroglossia, detected in 13 out of 50 patients [3].
• A low VIQ was associated with impaired hand skills (p < 0.0001) and the presence of preoperative hydrocephalus (p = 0.02), whereas a low PIQ was associated with impaired hand skills (p < 0.0001) and incision of the vermis (p = 0.02) [4].
• When cutoff value was set to mean +1 SD, abnormal PIQ was observed in 88% of IUGR fetuses [5].

Psychiatry related information on IQCB1

• Tests of performance I.Q. (PIQ), verbal I.Q. (VIQ), or recognition memory for word and verbal learning showed no significant difference between these groups [6].
• The CNS-irradiated group obtained lower scores than the other two groups, with significant differences in visual-motor and fine motor skills, spatial memory, and arithmetic achievement resulting in significant differences in IQ scores (VIQ, PIQ, FSIQ) [7].
• It is concluded that generally the NART can be used as a predictor of the premorbid intellectual functioning of a patient with dementia, given that the VIQ is greater than PIQ [8].
• Subjects with schizophrenia-related psychosis had a significantly lower mean value for premorbid PIQ, but not VIQ, compared to subjects who developed affective disorder or subjects without psychiatric disorder [9].
• A diagnosis of left hemisphere dysfunction (n = 13) was based on right side soft neurological signs, performance IQ (PIQ) > verbal IQ (VIQ), dyslexia and intact visuo-spatial functions [10].

High impact information on IQCB1

• All individuals with IQCB1 mutations have retinitis pigmentosa [11].
• Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin [11].
• Five nephrocystin (nephrocystin-1 to nephrocystin-5) genes, whose function is disrupted in NPH patients, have been identified and data indicate they form a complex at cell junctions and focal adhesions [12].
• The mothers using valproate scored significantly lower (p<0.05) in FIQ, VIQ and PIQ tests and had also significantly lower (p=0.035) educational level [13].
• VIQ was also predicted by the rCMRglc in the left parietal lobe, while PIQ was predicted by the age at onset [14].

Biological context of IQCB1

• As TS phenotypes are characterized by a particular profile of normal Verbal IQ (VIQ) and lowered Performance IQ (PIQ), we investigated whether there is a significant correlation between intelligence scores and motor performance scores [15].
• Pharmacokinetics and the accumulation of PIQ in normal and tumour tissues were also assessed using a chromatographic method [16].
• Using this value, we calculated PIQ of the descending aorta, umbilical artery, and middle cerebral artery in normal fetuses, IUGR fetuses, and distressed fetuses during 24-41 weeks gestation [5].
• Wechsler VIQ versus PIQ differences in cerebral dysfunction: a literature review with emphasis on sex differences [17].

Anatomical context of IQCB1

• We show that nephrocystin-5, RPGR and calmodulin can be coimmunoprecipitated from retinal extracts, and that these proteins localize to connecting cilia of photoreceptors and to primary cilia of renal epithelial cells [11].
• The PIQ of the fetal descending aorta in the IUGR fetus was significantly higher than that of the normal fetus [5].
• Proliferation was assessed using the MTT assay and PIQ showed activity, particularly with resistant cell lines [16].
• In the distressed fetuses, both PIQ and PIV of the umbilical artery increased, and these indices of the middle cerebral artery markedly decreased [5].
• The analyses also showed that frontal and temporal lobe regions were associated with the decline in VIQ, while occipital and temporal lobe regions (including the hippocampi) were associated with the decline in PIQ [18].

Associations of IQCB1 with chemical compounds

• In both, a case-by-case comparison and a comparison of the two entire groups, the phenytoin-exposed children had significantly lower scores for both Performance IQ (PIQ), Full Scale IQ (FSIQ), and Visual Motor Integration Test (VMIT) [19].
• The PIQ estimation algorithm used Matrix Reasoning and Picture Completion raw scores with demographic variables [20].
• Neurological factors such as the absence of suspected intracranial haemorrhage or seizures were predictors of PIQ and Freedom from Distractibility, respectively [21].

Analytical, diagnostic and therapeutic context of IQCB1

• PIQ derivatives are effective new antitumour agents in cancer chemotherapy [16].
• High postnatal morbidity (days with assisted ventilation, number of blood transfusions) and low birthweight standard deviation scores (SDS) were associated with lower PIQ than VIQ, while low postnatal morbidity and high birthweight were associated with higher PIQ than VIQ [22].
• In this study we compared results earned by brain-damaged and control groups on three measures of intelligence: Wechsler Verbal IQ (VIQ), Wechsler Performance IQ (PIQ), and the Henmon-Nelson Test (HNT) of Mental Ability [23].
• The mean score for this test is 50, with a SD of . RESULTS: No differences were identified among ICSI, IVF, and NC children with respect to VIQ, PIQ, or FSIQ scores of the WPPSI-R [24].

References