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Gene Review

IQCB1  -  IQ motif containing B1

Homo sapiens

Synonyms: IQ calmodulin-binding motif-containing protein 1, KIAA0036, NPHP5, Nephrocystin-5, OK/SW-cl.85, ...
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Disease relevance of IQCB1

  • Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers [1].
  • Children and adolescents with Klinefelter syndrome (XXY) have been reported to show deficits in language processing including VIQ < PIQ and a learning disability in reading and spelling [2].
  • Low PIQ correlated with the presence of macroglossia, detected in 13 out of 50 patients [3].
  • A low VIQ was associated with impaired hand skills (p < 0.0001) and the presence of preoperative hydrocephalus (p = 0.02), whereas a low PIQ was associated with impaired hand skills (p < 0.0001) and incision of the vermis (p = 0.02) [4].
  • When cutoff value was set to mean +1 SD, abnormal PIQ was observed in 88% of IUGR fetuses [5].

Psychiatry related information on IQCB1

  • Tests of performance I.Q. (PIQ), verbal I.Q. (VIQ), or recognition memory for word and verbal learning showed no significant difference between these groups [6].
  • The CNS-irradiated group obtained lower scores than the other two groups, with significant differences in visual-motor and fine motor skills, spatial memory, and arithmetic achievement resulting in significant differences in IQ scores (VIQ, PIQ, FSIQ) [7].
  • It is concluded that generally the NART can be used as a predictor of the premorbid intellectual functioning of a patient with dementia, given that the VIQ is greater than PIQ [8].
  • Subjects with schizophrenia-related psychosis had a significantly lower mean value for premorbid PIQ, but not VIQ, compared to subjects who developed affective disorder or subjects without psychiatric disorder [9].
  • A diagnosis of left hemisphere dysfunction (n = 13) was based on right side soft neurological signs, performance IQ (PIQ) > verbal IQ (VIQ), dyslexia and intact visuo-spatial functions [10].

High impact information on IQCB1


Biological context of IQCB1


Anatomical context of IQCB1


Associations of IQCB1 with chemical compounds

  • In both, a case-by-case comparison and a comparison of the two entire groups, the phenytoin-exposed children had significantly lower scores for both Performance IQ (PIQ), Full Scale IQ (FSIQ), and Visual Motor Integration Test (VMIT) [19].
  • The PIQ estimation algorithm used Matrix Reasoning and Picture Completion raw scores with demographic variables [20].
  • Neurological factors such as the absence of suspected intracranial haemorrhage or seizures were predictors of PIQ and Freedom from Distractibility, respectively [21].

Analytical, diagnostic and therapeutic context of IQCB1

  • PIQ derivatives are effective new antitumour agents in cancer chemotherapy [16].
  • High postnatal morbidity (days with assisted ventilation, number of blood transfusions) and low birthweight standard deviation scores (SDS) were associated with lower PIQ than VIQ, while low postnatal morbidity and high birthweight were associated with higher PIQ than VIQ [22].
  • In this study we compared results earned by brain-damaged and control groups on three measures of intelligence: Wechsler Verbal IQ (VIQ), Wechsler Performance IQ (PIQ), and the Henmon-Nelson Test (HNT) of Mental Ability [23].
  • The mean score for this test is 50, with a SD of . RESULTS: No differences were identified among ICSI, IVF, and NC children with respect to VIQ, PIQ, or FSIQ scores of the WPPSI-R [24].


  1. Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers. Luo, X., He, Q., Huang, Y., Sheikh, M.S. Cancer Res. (2005) [Pubmed]
  2. Neuropsychological profiles of adults with Klinefelter syndrome. Boone, K.B., Swerdloff, R.S., Miller, B.L., Geschwind, D.H., Razani, J., Lee, A., Gonzalo, I.G., Haddal, A., Rankin, K., Lu, P., Paul, L. Journal of the International Neuropsychological Society : JINS. (2001) [Pubmed]
  3. Cognitive impairment in Duchenne muscular dystrophy. Bresolin, N., Castelli, E., Comi, G.P., Felisari, G., Bardoni, A., Perani, D., Grassi, F., Turconi, A., Mazzucchelli, F., Gallotti, D. Neuromuscul. Disord. (1994) [Pubmed]
  4. Critical risk factors for intellectual impairment in children with posterior fossa tumors: the role of cerebellar damage. Grill, J., Viguier, D., Kieffer, V., Bulteau, C., Sainte-Rose, C., Hartmann, O., Kalifa, C., Dellatolas, G. J. Neurosurg. (2004) [Pubmed]
  5. Clinical application of pulsatility index of flow volume to detect the hemodynamic changes in IUGR fetus. Okagaki, A., Sagawa, N., Ihara, Y., Bano, C., Hasegawa, M., Inamori, K., Itoh, H., Mori, T. Journal of perinatal medicine. (1994) [Pubmed]
  6. Cognitive effects of resecting basal temporal language areas. Krauss, G.L., Fisher, R., Plate, C., Hart, J., Uematsu, S., Gordon, B., Lesser, R.P. Epilepsia (1996) [Pubmed]
  7. Neuropsychological sequelae of childhood cancer in long-term survivors. Copeland, D.R., Fletcher, J.M., Pfefferbaum-Levine, B., Jaffe, N., Ried, H., Maor, M. Pediatrics (1985) [Pubmed]
  8. A longitudinal study of reading ability in patients suffering from dementia. Paque, L., Warrington, E.K. Journal of the International Neuropsychological Society : JINS. (1995) [Pubmed]
  9. Premorbid performance IQ deficit in schizophrenia. Amminger, G.P., Schlögelhofer, M., Lehner, T., Looser Ott, S., Friedrich, M.H., Aschauer, H.N. Acta psychiatrica Scandinavica. (2000) [Pubmed]
  10. Developmental dyscalculia and brain laterality. Shalev, R.S., Manor, O., Amir, N., Wertman-Elad, R., Gross-Tsur, V. Cortex; a journal devoted to the study of the nervous system and behavior. (1995) [Pubmed]
  11. Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin. Otto, E.A., Loeys, B., Khanna, H., Hellemans, J., Sudbrak, R., Fan, S., Muerb, U., O'Toole, J.F., Helou, J., Attanasio, M., Utsch, B., Sayer, J.A., Lillo, C., Jimeno, D., Coucke, P., De Paepe, A., Reinhardt, R., Klages, S., Tsuda, M., Kawakami, I., Kusakabe, T., Omran, H., Imm, A., Tippens, M., Raymond, P.A., Hill, J., Beales, P., He, S., Kispert, A., Margolis, B., Williams, D.S., Swaroop, A., Hildebrandt, F. Nat. Genet. (2005) [Pubmed]
  12. The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception. Winkelbauer, M.E., Schafer, J.C., Haycraft, C.J., Swoboda, P., Yoder, B.K. J. Cell. Sci. (2005) [Pubmed]
  13. Children exposed to valproate in utero--population based evaluation of risks and confounding factors for long-term neurocognitive development. Eriksson, K., Viinikainen, K., Mönkkönen, A., Aikiä, M., Nieminen, P., Heinonen, S., Kälviäinen, R. Epilepsy Res. (2005) [Pubmed]
  14. Relationship between both IQ and Mini-Mental State Examination and the regional cerebral glucose metabolism in clinically diagnosed Alzheimer's disease: a PET study. Kawano, M., Ichimiya, A., Ogomori, K., Kuwabara, Y., Sasaki, M., Yoshida, T., Tashiro, N. Dementia and geriatric cognitive disorders. (2001) [Pubmed]
  15. Motor performance in girls with Turner syndrome. Nijhuis-van der Sanden, R.W., Smits-Engelsman, B.C., Eling, P.A. Developmental medicine and child neurology. (2000) [Pubmed]
  16. In vitro and in vivo pharmacological characterisation of the antitumour properties of pyrido[1',2':1,2]imidazo[4,5-h]quinazoline. Dupuy, M., Blache, Y., Bailly, C., Poujol, S., Chapat, J.P., Pinguet, F. Anticancer Res. (2002) [Pubmed]
  17. Wechsler VIQ versus PIQ differences in cerebral dysfunction: a literature review with emphasis on sex differences. Bornstein, R.A., Matarazzo, J.D. Journal of clinical neuropsychology. (1982) [Pubmed]
  18. Brain morphometry and IQ measurements in preterm children. Isaacs, E.B., Edmonds, C.J., Chong, W.K., Lucas, A., Morley, R., Gadian, D.G. Brain (2004) [Pubmed]
  19. The effects of prenatal exposure to phenytoin and other anticonvulsants on intellectual function at 4 to 8 years of age. Vanoverloop, D., Schnell, R.R., Harvey, E.A., Holmes, L.B. Neurotoxicology and teratology. (1992) [Pubmed]
  20. Differential estimation of verbal intelligence and performance intelligence scores from combined performance and demographic variables: the OPIE-3 verbal and performance algorithms. Schoenberg, M.R., Duff, K., Dorfman, K., Adams, R.L. The Clinical neuropsychologist. (2004) [Pubmed]
  21. A controlled study of children born at gestation 28 weeks or less: psychological characteristics at seven to ten years of age. Harding, L., Walker, L.G., Lloyd, D., Duffty, P. Health bulletin. (2001) [Pubmed]
  22. Large variability in performance IQ associated with postnatal morbidity, and reduced verbal IQ among school-aged children born preterm. Gabrielson, J., Hård, A.L., Ek, U., Svensson, E., Carlsson, G., Hellström, A. Acta Paediatr. (2002) [Pubmed]
  23. The differential effect of conation on intelligence test scores among brain-damaged and control subjects. Reitan, R.M., Wolfson, D. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. (2004) [Pubmed]
  24. International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Ponjaert-Kristoffersen, I., Bonduelle, M., Barnes, J., Nekkebroeck, J., Loft, A., Wennerholm, U.B., Tarlatzis, B.C., Peters, C., Hagberg, B.S., Berner, A., Sutcliffe, A.G. Pediatrics (2005) [Pubmed]
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