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Chemical Compound Review

pregnanediol     17-(1-hydroxyethyl)-10,13- dimethyl-2,3,4,5...

Synonyms: AGN-PC-00CAWI, SureCN13979883, NSC-224267, Oprea1_566549, NSC 1612, ...
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Disease relevance of pregnanediol

  • Urine levels of three major estrogens and of pregnanediol were measured for 76 nulliparous daughters of breast cancer patients and for 115 control women of similar age and parity [1].
  • Spontaneous ovarian activity, as reflected by the urinary excretion of total estrogen and pregnanediol measured serially (thrice weekly) over a period of 3-4 months, was studied in nine young women (15-27 yr old) with a history of dysfunctional uterine bleeding of at least 2-yr duration [2].
  • The OVEIA assay, a simultaneous measurement of oestrone and pregnanediol glucuronides, for studying the treatment of infertility patients [3].
  • One hundred patients admitted to hospital with a diagnosis of threatened abortion were assessed by means of sonar, urinary oestrogen, pregnanediol and human chorionic gonadotrophin (HCG) assays and clinical examination [4].
  • Urinary oestrogen and pregnanediol excretion, endometrial and ovarian pathology and body weight in women with postmenopausal bleeding [5].

Psychiatry related information on pregnanediol


High impact information on pregnanediol


Chemical compound and disease context of pregnanediol


Biological context of pregnanediol


Anatomical context of pregnanediol


Associations of pregnanediol with other chemical compounds


Gene context of pregnanediol


Analytical, diagnostic and therapeutic context of pregnanediol


  1. Elevated urine estrogen and pregnanediol levels in daughters of breast cancer patients. Trichopoulos, D., Brown, J.B., Garas, J., Papaioannou, A., MacMahon, B. J. Natl. Cancer Inst. (1981) [Pubmed]
  2. Impaired estrogen-induced luteinizing hormone release in young women with anovulatory dysfunctional uterine bleeding. Van Look, P.F., Hunter, W.M., Fraser, I.S., Baird, D.T. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  3. The OVEIA assay, a simultaneous measurement of oestrone and pregnanediol glucuronides, for studying the treatment of infertility patients. Anthony, F., Aldrich, C., Sharp, N.C., Smith, E.M., Masson, G.M., Dennis, K.J. Hum. Reprod. (1988) [Pubmed]
  4. Prognosis in threatened abortion: a comparison between predictions made by sonar urinary hormone assays and clinical judgement. Duff, G.B. British journal of obstetrics and gynaecology. (1975) [Pubmed]
  5. Urinary oestrogen and pregnanediol excretion, endometrial and ovarian pathology and body weight in women with postmenopausal bleeding. Reti, L.L., Rome, R.M., Brown, J.B., Fortune, D.W. British journal of obstetrics and gynaecology. (1978) [Pubmed]
  6. The effect of ovarian follicle size on pituitary and ovarian responses to copulation in domesticated South American camelids. Bravo, P.W., Stabenfeldt, G.H., Lasley, B.L., Fowler, M.E. Biol. Reprod. (1991) [Pubmed]
  7. Endogenous sex hormones, prolactin, and breast cancer in premenopausal women. Meyer, F., Brown, J.B., Morrison, A.S., MacMahon, B. J. Natl. Cancer Inst. (1986) [Pubmed]
  8. Endogenous sex hormones, prolactin, and mammographic features of breast tissue in premenopausal women. Meyer, F., Brisson, J., Morrison, A.S., Brown, J.B. J. Natl. Cancer Inst. (1986) [Pubmed]
  9. Urine estrogens, frequency of ovulation, and breast cancer risk: case-control study in premenopausal women. MacMahon, B., Cole, P., Brown, J.B., Paffenbarger, R., Trichopoulos, D., Yen, S. J. Natl. Cancer Inst. (1983) [Pubmed]
  10. Estrogen profiles of primiparous and nulliparous women in Athens, Greece. Trichopoulos, D., Cole, P., Brown, J.B., Goldman, M.B., MacMahon, B. J. Natl. Cancer Inst. (1980) [Pubmed]
  11. Hormonal status of breast cancer. I. Thoretical basis for the analysis of steroid profile. Kodama, M., Kodama, T. J. Natl. Cancer Inst. (1975) [Pubmed]
  12. Hormonal status of breast cancer. II. Abnormal urinary steroid excretion. Kodama, M., Kodama, T., Yoshida, M., Totania, R., Aoki, K. J. Natl. Cancer Inst. (1975) [Pubmed]
  13. Hormone patterns during bromocriptine-induced pregnancy in hyperprolactinemic patients. Belforte, L., Bruno, M., Campagnoli, C., Fessia, L., Massara, F., Molinatti, G.M. Eur. J. Obstet. Gynecol. Reprod. Biol. (1980) [Pubmed]
  14. Luteinizing hormone releasing hormone agonist for contraception in breast feeding women. Fraser, H.M., Dewart, P.J., Smith, S.K., Cowen, G.M., Sandow, J., McNeilly, A.S. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  15. Endogenous luteinizing hormone surge during superovulation induction with sequential use of clomiphene citrate and pulsatile human menopausal gonadotropin. Messinis, I.E., Templeton, A., Baird, D.T. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  16. The value of urinary pregnanediol estimation for monitoring early pregnancies. Bernstein, D., Frishman, H.B., Levin, S., Schwartz, S. Fertil. Steril. (1978) [Pubmed]
  17. Effects of postovulatory estradiol benzoate administration on women's ovarian function. Oriol-Bosch, A., Cortés, J. Fertil. Steril. (1975) [Pubmed]
  18. Fertility after childbirth: adequacy of post-partum luteal phases. McNeilly, A.S., Howie, P.W., Houston, M.J., Cook, A., Boyle, H. Clin. Endocrinol. (Oxf) (1982) [Pubmed]
  19. Relationships between ovarian morphology, vaginal cytology, serum progesterone, and urinary immunoreactive pregnanediol during the menstrual cycle of the cynomolgus monkey. Mehta, R.R., Jenco, J.M., Gaynor, L.V., Chatterton, R.T. Biol. Reprod. (1986) [Pubmed]
  20. Glycogen estimation by a rapid enzymic method in very small samples of human endometrium: glycogen content in the endometrium of infertile patients during the menstrual cycle. Maeyama, M., Sudo, I., Saito, K., Matsuo, I., Nakahara, K. Fertil. Steril. (1977) [Pubmed]
  21. Placental production of 5 beta-pregnane-3 alpha,20 alpha-diol in goats. Sheldrick, E.L., Ricketts, A.P., Flint, A.P. J. Endocrinol. (1981) [Pubmed]
  22. Breast-milk jaundice. Brooten, D., Brown, L., Hollingsworth, A., Tanis, J., Bakewell-Sachs, S. Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG. (1985) [Pubmed]
  23. Concerted metabolism of steroid hormones produced by cocultured ovarian cell types. Goldring, N.B., Orly, J. J. Biol. Chem. (1985) [Pubmed]
  24. Low bone mineral density in the early menopausal transition: role for ovulatory function. Grewal, J., Sowers, M.R., Randolph, J.F., Harlow, S.D., Lin, X. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  25. Characterization of reproductive hormonal dynamics in the perimenopause. Santoro, N., Brown, J.R., Adel, T., Skurnick, J.H. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  26. Identification and measurement of urinary estrone, estradiol-17 beta, estriol, pregnanediol and androsterone during the menstrual cycle of the orangutan. Collins, D.C., Graham, C.E., Preedy, J.R. Endocrinology (1975) [Pubmed]
  27. Long-term administration of thyrotropin-releasing hormone and its effect on gonadotropin secretion in eumenorrheic women. Lasso, P., Zárate, A., Soria, J., Canales, E.S. Fertil. Steril. (1976) [Pubmed]
  28. Hormones, mood and sexuality in lactating women. Alder, E.M., Cook, A., Davidson, D., West, C., Bancroft, J. The British journal of psychiatry : the journal of mental science. (1986) [Pubmed]
  29. Persistent pregnanediol glucuronide secretion after gonadotrophin suppression indicates adrenal source of progesterone in premature ovarian failure. Sachdev, R., Von Hagen, S., Kamnani, A., Santoro, N. Hum. Reprod. (1998) [Pubmed]
  30. Long-acting gonadotrophin releasing hormone agonist implant causes variable duration of suppression of ovarian steroid and inhibin secretion. Fraser, H.M., Haining, R., Cowen, G.M., Sandow, J., Smith, K.B., Smith, S.K. Clin. Endocrinol. (Oxf) (1992) [Pubmed]
  31. Serum acetone and liver acetone monooxygenase activity in pregnant rats, fetuses, and neonates: reversible pretranslational reduction of cytochrome P450IIE1 (P450IIE1) during pregnancy. Casazza, J.P., Sohn, D.H., Park, K.S., Song, B.J. Arch. Biochem. Biophys. (1994) [Pubmed]
  32. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research. O'Connor, K.A., Brindle, E., Holman, D.J., Klein, N.A., Soules, M.R., Campbell, K.L., Kohen, F., Munro, C.J., Shofer, J.B., Lasley, B.L., Wood, J.W. Clin. Chem. (2003) [Pubmed]
  33. Radioimmunoassay of pregnanediol concentrations in early morning urine specimens for assessment of luteal function in women. Chatterton, R.T., Haan, J.N., Jenco, J.M., Cheesman, K.L. Fertil. Steril. (1982) [Pubmed]
  34. Retention of normal ovarian function after hysterectomy. Metcalf, M.G., Braiden, V., Livesey, J.H. J. Endocrinol. (1992) [Pubmed]
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