The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Antisepsis


High impact information on Antisepsis

  • In this report, we demonstrate that LL-37 is a potent antisepsis agent with the ability to inhibit macrophage stimulation by bacterial components such as LPS, lipoteichoic acid, and noncapped lipoarabinomannan [6].
  • Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate [7].
  • Experimental evaluation of chlorhexidine gluconate for ocular antisepsis [8].
  • Tetracycline: from antibiotic to antisepsis [9].
  • OBJECTIVE: To compare effectiveness in preventing central venous catheter colonization and infection of two protocols of cutaneous antisepsis using povidone-iodine solution in combination with ethanol or water [10].

Biological context of Antisepsis


Anatomical context of Antisepsis

  • Presently, periorbital skin antisepsis with PVP-I cannot be recommended until data on thyroid metabolism in the population have been collected and evaluated, especially in a region currently or previously deficient in iodine [12].
  • Microbiological samples were taken from the umbilicus before (group 1) and after (group 2) antisepsis with povidone-iodine [13].
  • The low prevalence of udder bacteria contributing to the contamination of the milk was attributed to the milking management practices carried out in these herds, in particular pre-milking and post-milking antisepsis [14].

Associations of Antisepsis with chemical compounds


Gene context of Antisepsis

  • Methicillin-resistant Staphylococcus aureus (MRSA) has emerged worldwide as a significant and difficult-to-treat source of nosocomial infection, emphasizing the ever-present need for reliable and effective antisepsis [19].
  • CONCLUSIONS: Hand antisepsis with an alcoholic-hand-gel regimen was well tolerated and did not result in skin irritation and dryness of nurses' hands [20].
  • METHODS: Before povidone-iodine antisepsis, eye-swab specimens were collected from adolescent corneal donors preceding corneal excision and from children during preparation for strabismus surgery [21].

Analytical, diagnostic and therapeutic context of Antisepsis


  1. Bacterial endophthalmitis prophylaxis for cataract surgery: an evidence-based update. Ciulla, T.A., Starr, M.B., Masket, S. Ophthalmology (2002) [Pubmed]
  2. Reduction of colonization and infection rate during pediatric intensive care by selective decontamination of the digestive tract. Zobel, G., Kuttnig, M., Grubbauer, H.M., Semmelrock, H.J., Thiel, W. Crit. Care Med. (1991) [Pubmed]
  3. Methicillin resistant Staphylococcus aureus; the role of antisepsis in the control of an outbreak. Tuffnell, D.J., Croton, R.S., Hemingway, D.M., Hartley, M.N., Wake, P.N., Garvey, R.J. J. Hosp. Infect. (1987) [Pubmed]
  4. Antiseptic wound ventilation with a gas diffuser: a new intraoperative method to prevent surgical wound infection? Persson, M., Flock, J.I., van der Linden, J. J. Hosp. Infect. (2003) [Pubmed]
  5. A comparison of the effect of chlorhexidine antisepsis, soap and antibiotics on bacteriuria, perineal colonization and environmental contamination in spinally injured patients. Sanderson, P.J., Weissler, S. J. Hosp. Infect. (1990) [Pubmed]
  6. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. Scott, M.G., Davidson, D.J., Gold, M.R., Bowdish, D., Hancock, R.E. J. Immunol. (2002) [Pubmed]
  7. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate. Yamada, M., Ichikawa, T., Ii, M., Sunamoto, M., Itoh, K., Tamura, N., Kitazaki, T. J. Med. Chem. (2005) [Pubmed]
  8. Experimental evaluation of chlorhexidine gluconate for ocular antisepsis. Hamill, M.B., Osato, M.S., Wilhelmus, K.R. Antimicrob. Agents Chemother. (1984) [Pubmed]
  9. Tetracycline: from antibiotic to antisepsis. Bar-Or, D., Melamed, I. Crit. Care Med. (2005) [Pubmed]
  10. Alcoholic povidone-iodine to prevent central venous catheter colonization: A randomized unit-crossover study. Parienti, J.J., du Cheyron, D., Ramakers, M., Malbruny, B., Leclercq, R., Le Coutour, X., Charbonneau, P. Crit. Care Med. (2004) [Pubmed]
  11. Systemic metronidazole combined with either topical povidone-iodine or ampicillin in acute appendicitis. Parker, M.C., Mathams, A. J. Hosp. Infect. (1985) [Pubmed]
  12. Systemic iodine absorption after preoperative antisepsis using povidone-iodine in cataract surgery-- an open controlled study. Below, H., Behrens-Baumann, W., Bernhardt, C., Völzke, H., Kramer, A., Rudolph, P. Dermatology (Basel) (2006) [Pubmed]
  13. Is umbilical flora responsible for wound infection after laparoscopic surgery? Hamzaoglu, I., Baca, B., Böler, D.E., Polat, E., Ozer, Y. Surgical laparoscopy, endoscopy & percutaneous techniques. (2004) [Pubmed]
  14. Prevalence of udder bacteria in milk samples from four dairy goat herds. Ryan, D.P., Greenwood, P.L. Aust. Vet. J. (1990) [Pubmed]
  15. Use of povidone-iodine for intravaginal and periumbilical antisepsis. Clemens, P., Plettner, C., Grüttner, R. J. Pediatr. (1985) [Pubmed]
  16. Comparison of four antiseptic preparations for skin in the prevention of contamination of percutaneously drawn blood cultures: a randomized trial. Calfee, D.P., Farr, B.M. J. Clin. Microbiol. (2002) [Pubmed]
  17. Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects. Guthery, E., Seal, L.A., Anderson, E.L. American journal of infection control. (2005) [Pubmed]
  18. An outbreak of bloodstream infections in an outpatient hemodialysis center. Price, C.S., Hacek, D., Noskin, G.A., Peterson, L.R. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2002) [Pubmed]
  19. In vitro efficacy of povidone-iodine solution and cream against methicillin-resistant Staphylococcus aureus. Goldenheim, P.D. Postgraduate medical journal. (1993) [Pubmed]
  20. Skin irritation and dryness associated with two hand-hygiene regimens: soap-and-water hand washing versus hand antisepsis with an alcoholic hand gel. Boyce, J.M., Kelliher, S., Vallande, N. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2000) [Pubmed]
  21. Molecular analysis of the pediatric ocular surface for fungi. Wu, T., Mitchell, B., Carothers, T., Coats, D., Brady-McCreery, K., Paysse, E., Wilhelmus, K. Curr. Eye Res. (2003) [Pubmed]
  22. Prospective randomized trial of 10% povidone-iodine versus 0.5% tincture of chlorhexidine as cutaneous antisepsis for prevention of central venous catheter infection. Humar, A., Ostromecki, A., Direnfeld, J., Marshall, J.C., Lazar, N., Houston, P.C., Boiteau, P., Conly, J.M. Clin. Infect. Dis. (2000) [Pubmed]
  23. Comparison of 5% povidone-iodine solution against 1% povidone-iodine solution in preoperative cataract surgery antisepsis: a prospective randomised double blind study. Ferguson, A.W., Scott, J.A., McGavigan, J., Elton, R.A., McLean, J., Schmidt, U., Kelkar, R., Dhillon, B. The British journal of ophthalmology. (2003) [Pubmed]
WikiGenes - Universities