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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Antigenic Modulation

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Disease relevance of Antigenic Modulation


High impact information on Antigenic Modulation

  • The complement-dependent cytotoxicity test was used to study the possibility of antigenic modulation for these cell-surface antigens from the surface of the GRSL cells could be modulated by preincubation with anti-MuMTV serum, in contrast to H-2.8 and Thy 1.2 antigens [6].
  • These observations demonstrate that HUVE cells show distinct but overlapping patterns of antigenic modulation in response to three different lymphokines, and suggest that the "activation" of endothelial cells observed in situ may represent a complex integration of several lymphokine-mediated signals [7].
  • Because all of these modulate the receptor, these data indicate that the functional difference between monovalent and bivalent binding to CD3 is related to antibody valency and not to antigenic modulation [8].
  • In the present study, we examined the antigenic modulation of AChR by using patients' sera and cultures of human muscle cells [9].
  • We here examine the relative contribution of the anti-MIR antibody fraction (as well as of another fraction) to the antigenic modulation caused by MG patients' sera [3].

Chemical compound and disease context of Antigenic Modulation


Biological context of Antigenic Modulation


Anatomical context of Antigenic Modulation


Associations of Antigenic Modulation with chemical compounds


Gene context of Antigenic Modulation

  • The present study concerns the antibody-induced antigenic modulation of CD4, CD5, CD7, and 150-kDa antigens present on cells of the CCRF-CEM human T line [19].
  • Capping of sIg via antigen binding (i.e. antigenic modulation) constitutes the initial signal for B-cell activation [20].
  • Incubation of human leukemic cells expressing CALLA with specific monoclonal antibody (J5) at 37 degrees C causes rapid and selective internalization and degradation of this antigen (antigenic modulation) [21].
  • The assay has also been used to quantitate the changes in TL antigen expression on cells incubated in anti-TL antisera under conditions of antigenic modulation [22].
  • Antigenic modulation of INF-lymph obtained from HLA-A1+ individuals with HLA-A1 typing alloantisera eliminated subsequent lysis mediated by HLA-A1 alloantibodies and complement but not lysis with platelet absorbed antibodies included in the cluster associated with HLA-A1 [23].


  1. Loss of the endothelin signal pathway in C6 rat glioma cells persistently infected with measles virus. Tas, P.W., Koschel, K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Molecular nature of a cell membrane antigen specific for human T-cell acute lymphoblastic leukemia. Matsuzaki, H., Seon, B.K. Cancer Res. (1987) [Pubmed]
  3. Role of the main immunogenic region of acetylcholine receptor in myasthenia gravis. An Fab monoclonal antibody protects against antigenic modulation by human sera. Tzartos, S.J., Sophianos, D., Efthimiadis, A. J. Immunol. (1985) [Pubmed]
  4. Antigenic modulation induced by monoclonal antibodies: antibodies to measles virus hemagglutinin alters expression of other viral polypeptides in infected cells. Fujinami, R.S., Norrby, E., Oldstone, M.B. J. Immunol. (1984) [Pubmed]
  5. Passive transfer of experimental myasthenia gravis via antigenic modulation of acetylcholine receptor. Loutrari, H., Kokla, A., Tzartos, S.J. Eur. J. Immunol. (1992) [Pubmed]
  6. Antibody-induced modulation and shedding of mammary tumor virus antigens on the surfaces of GR ascites leukemia cells as compared with normal antigens. Calafat, J., Hilgers, J., Van Bitterswijk, W.J., Verbeet, M., Hageman, P.C. J. Natl. Cancer Inst. (1976) [Pubmed]
  7. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. Pober, J.S., Gimbrone, M.A., Lapierre, L.A., Mendrick, D.L., Fiers, W., Rothlein, R., Springer, T.A. J. Immunol. (1986) [Pubmed]
  8. Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation. Ledbetter, J.A., June, C.H., Martin, P.J., Spooner, C.E., Hansen, J.A., Meier, K.E. J. Immunol. (1986) [Pubmed]
  9. Antigenic modulation of human myotube acetylcholine receptor by myasthenic sera. Serum titer determines receptor internalization rate. Tzartos, S.J., Sophianos, D., Zimmerman, K., Starzinski-Powitz, A. J. Immunol. (1986) [Pubmed]
  10. In vitro antigenic modulation of human neuroblastoma cells induced by IFN-gamma, retinoic acid and dibutyryl cyclic AMP. Gross, N., Beck, D., Favre, S., Carrel, S. Int. J. Cancer (1987) [Pubmed]
  11. Antibody affinity may influence antigenic modulation of the common acute lymphoblastic leukemia antigen in vitro. Lebien, T.W., Boué, D.R., Bradley, J.G., Kersey, J.H. J. Immunol. (1982) [Pubmed]
  12. Repressor binding to a regulatory site in the DNA coding sequence is sufficient to confer transcriptional regulation of the vir-repressed genes (vrg genes) in Bordetella pertussis. Beattie, D.T., Mahan, M.J., Mekalanos, J.J. J. Bacteriol. (1993) [Pubmed]
  13. Decrease in acetylcholine-receptor content of human myotube cultures mediated by monoclonal antibodies to alpha, beta and gamma subunits. Tzartos, S.J., Starzinski-Powitz, A. FEBS Lett. (1986) [Pubmed]
  14. Decreased expression of CD7 occurs in rheumatoid arthritis. Lazarovits, A.I., Karsh, J. Clin. Exp. Immunol. (1988) [Pubmed]
  15. Bacterial expression of a single-chain Fv fragment which efficiently protects the acetylcholine receptor against antigenic modulation caused by myasthenic antibodies. Mamalaki, A., Trakas, N., Tzartos, S.J. Eur. J. Immunol. (1993) [Pubmed]
  16. Antigenic modulation of mammary tumour virus envelope antigen or GR thymic lymphoma cells in relation to expressions of H-2, TL cell-surface antigens and THY1. Hilgers, J., Sonnenberg, A., Nusse, R. Br. J. Cancer (1980) [Pubmed]
  17. Cytogenetic effects of 1-p-(3-methyltriazeno)benzoic acid potassium salt on human lymphocytes in vitro. Vernole, P., Caporossi, D., Tedeschi, B., Porfirio, B., Melino, G., Bonmassar, E., Nicoletti, B. Mutat. Res. (1987) [Pubmed]
  18. Lung injury mediated by antibodies to endothelium. III. Effect of chlorpromazine in rabbits. Camussi, G., Brentjens, J.R., Andres, G., Caldwell, P.R. Exp. Lung Res. (1990) [Pubmed]
  19. Antigenic modulation induced by four monoclonal antibodies adsorbed on gold particles (specificity anti-CD4, anti-CD5, anti-CD7, and anti-150-kDa antigen): relationship between modulation and cytotoxic activity of immunotoxins. Carriere, D., Arcier, J.M., Derocq, J.M., Fontaine, C., Richer, G. Exp. Cell Res. (1989) [Pubmed]
  20. Major immunoglobulin capping deficiency in the peripheral blood B cells of patients with Sjögren's syndrome. Bataille, R., Zhang, X.G., Duperray, C., Rajzbaum, G., Brochier, J., Klein, B. Immunology (1992) [Pubmed]
  21. Distribution and modulation of a human leukemia-associated antigen (CALLA). Pesando, J.M., Tomaselli, K.J., Lazarus, H., Schlossman, S.F. J. Immunol. (1983) [Pubmed]
  22. An indirect radioimmunoassay for thymus leukemia (TL) antigens. Esmon, N.L., Little, J.R. J. Immunol. (1976) [Pubmed]
  23. Lymphocytes modulated by beta interferon express new non-HLA-A,B,C class I antigens. Gazit, E., Gil, R., Altshuler, R. Hum. Immunol. (1987) [Pubmed]
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